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CAS No.: 301836-43-1
Synonyms: Casein Kinase I Inhibitor
D4476 is a potent, selective, and cell-permeant CK1 (casein kinase 1) inhibitor with IC50 of 200 nM and 300 nM in a cell-free assay for CK1 from Schizosaccharomyces pombe and CK1δ, respectively. Also acts as an ALK5 inhibitor with IC50 of 500 nM.
生物活性
动物研究 | |
剂量 | Mice[3] (i.p.): 15 mg/kg |
给药途径 | i.p. |
实验方案
技术信息
CAS号 | 301836-43-1 | 储存条件 |
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分子式 | C23H18N4O3 | 运输 | 蓝冰 | |||||
分子量 | 398.41 | 别名 | Casein Kinase I Inhibitor | |||||
溶解度 |
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动物实验配方 |
Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
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A375 cells | 10-80 μM | Function assay | 48 h | Inhibition of CK1-MDM2 complex in human A375 cells assessed as increase in p21 protein level at 10 to 80 uM after 48 hrs by immunoblotting analysis | 24007918 |
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