CAS No.: 1193447-34-5
CRANAD-2 Catalog No. CSN23259
Synonyms: Cranad 2
CRANAD-2 is a difluoroboron-derivatized curcumins as near-infrared probe for in vivo detection of amyloid-beta deposits. Upon interacting with Abeta aggregates, CRANAD-2 undergoes a range of changes, which include a 70-fold fluorescence intensity increase, a 90 nm blue shift (from 805 to 715 nm), and a large increase in quantum yield. Moreover, this probe also shows a high affinity for Abeta aggregates (K(d) = 38.0 nM), a reasonable log P value (log P = 3), considerable stability in serum, and a weak interaction with albumin. After intravenous injection of this probe, 19-month-old Tg2576 mice exhibited significantly higher relative signal than that of the control mice over the same period of time.
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400-920-2911
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tech@csnpharm.cn靶点选择性
生物活性
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1193447-34-5 | 储存条件 |
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| 分子式 | C23H25BF2N2O2 | 运输 | 蓝冰 | |||||
| 分子量 | 410.26 | 别名 | Cranad 2 | |||||
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动物实验配方 |
