18331-34-5|5-Benzylidene-3-ethyl-2-thioxothiazolidin-4-one|CsnPharm

CAS No.: 18331-34-5

BTR-1 Catalog No. CSN23777

BTR-1 is a rhodanine derivative induced cytotoxicity in a time- and concentration-dependent manner on leukemic cell line, leading to increased level of ROS production and DNA strand breaks suggesting activation of apoptosis for induction of cell death.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述BTR-1 is an active anti-cancer agent, causes S phase arrest, and affects DNA replication in leukemic cells. BTR-1 activates apoptosis and induces cell death. BTR-1 (10, 50, 100, and 250 µM, 5 days) dose-dependently causes cytotoxicity in human leukemic cells, with IC50s of 8 and 6 µM at 48 and 72 h, respectively^[1]. BTR-1 is essential to larval midgut epithelial organization during rapid cell proliferation and tissue growth in M. sexta because disruption of such organization and functionality occasioned by the binding of the Cry1A toxins of B. thuringiensis to BTR-1 causes death to the insect^[2].
参考文献

[1] Moorthy BT, Ravi S, Srivastava M, Chiruvella KK, Hemlal H, Joy O, Raghavan SC. Novel rhodanine derivatives induce growth inhibition followed by apoptosis. Bioorg Med Chem Lett. 2010 Nov 1;20(21):6297-301
[2] Midboe EG, Candas M, Bulla LA Jr. Expression of a midgut-specific cadherin BTR-1 during the development of Manduca sexta larva. Comp Biochem Physiol B Biochem Mol Biol. 2003 May;135(1):125-37

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.0104 mL
- 20.0520 mL
- 40.1040 mL
- 5 mM
- 0.8021 mL
- 4.0104 mL
- 8.0208 mL
- 10 mM
- 0.4010 mL
- 2.0052 mL
- 4.0104 mL

技术信息

CAS号

18331-34-5

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C12H11NOS2

运输

蓝冰

分子量

249.35

别名

溶解度

DMSO	25.0 mg/mL (100.3 mM) warming
Water	Insoluble

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

BTR-1 Catalog No. CSN23777

靶点选择性

请登录您的专属账户

确认信息