CAS No.: 66389-74-0
(+)-Apogossypol Catalog No. CSN18376
Synonyms: Apogossypol;NSC736630
(+)-Apogossypol is a potent inhibitor of Bcl-2 family proteins and competes with the BH3 peptide-binding sites on Bcl-2, Bcl-XL, Mcl-1, Bcl-W, and Bcl-B, but not Bfl-1, with IC50s of 0.5 to 2 μM.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Kitada S, Kress CL, et al. Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048). Blood. 2008 Mar 15;111(6):3211-9.
- [2] Becattini B, Kitada S, et al. Rational design and real time, in-cell detection of the proapoptotic activity of a novel compound targeting Bcl-X(L). Chem Biol. 2004 Mar;11(3):389-95.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 66389-74-0 | 储存条件 |
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| 分子式 | C28H30O6 | 运输 | 蓝冰 | |
| 分子量 | 462.53 | 别名 | Apogossypol;NSC736630 |
