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PDE

PDE

货号 产品名 CAS号 信息
CSN12231 Zardaverine 101975-10-4 Zardaverine is a dual-selective PDE3/4 inhibitor with IC50 values of 0.5 μM and 0.8 μM respectively.
CSN12204 Vinpocetine 42971-09-5 Vinpocetine is a selective inhibitor for PDE1 with IC50 of 21 μM, it also blocks voltage-gated Na+ channels. It's a natural product isolated and purified from the herbs of Catharanthus roseus (L.) G. Don.
CSN12196 Vesnarinone 81840-15-5 Vesnarinone is a PDE3 inhibitor with IC50 value of 1.1μM for inhibiton of HERG current.
CSN13690 Vardenafil 224785-90-4 Vardenafil is a PDE5 inhibitor used for treating erectile dysfunction.
CSN12189 2-(2-Ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one hydrochloride trihydrate 330808-88-3 Vardenafil HCl is a type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively.
CSN12190 Vardenafil HCl 224785-91-5 Vardenafil HCl is a PDE5 inhibitor used for treating erectile dysfunction.
CSN12994 Udenafil 268203-93-6 Udenafil is a PDE5 inhibitor used in urology to treat erectile dysfunction.
CSN11923 5-(2-Ethoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one 139755-83-2 Sildenafil, one of the selective phosphodiesterase-5 (PDE5) inhibitors (IC50= 5.22 nM), is considered the best treatment for erectile dysfunction.
CSN11924 Sildenafil Citrate 171599-83-0 Sildenafil citrate, one of the selective phosphodiesterase-5 (PDE5) inhibitors (IC50= 5.22 nM), is considered the best treatment for erectile dysfunction.
CSN11859 Rolipram 61413-54-5 Rolipram is a selective inhibitor of phosphodiesterases PDE 4, especially the PDE 4B with IC50 of 130 nM while IC50 for PDE4D is 240 nM, it's an anti-inflammatory agent.
CSN11857 3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide   162401-32-3 Roflumilast is a selective and long-acting inhibitor of PDE-4 with IC50 of 0.8 nM.
CSN11838 Revizinone 133718-29-3 Revizinone is a selective phosphodiesterase (PDE) inhibitor with IC50 values on this enzyme to 0.036 mM.
CSN11723 Pimobendan 74150-27-9 Pimobendan is a selective inhibitor of PDE3 with IC50 of 0.32 μM.
CSN13560 PF-8380 1144035-53-9 PF-8380 is a potent and specific autotaxin inhibitor with IC50 of 2.8 nM.
CSN12802 Mardepodect 898562-94-2 PF-2545920 is a potent and selective PDE10A inhibitor with IC50 of 0.37 nM, with > 1000-fold selectivity over the other PDEs.
CSN10102 Pentoxifylline 6493-05-6 Pentoxifylline is a competitive nonselective phosphodiesterase inhibitor.
CSN10027 Olprinone 106730-54-5 Olprinone is a selective phosphodiesterase 3 (PDE3) inhibitor.
CSN11605 Olprinone HCl 119615-63-3 Olprinone HCl is a selective phosphodiesterase 3 (PDE3) inhibitor.
CSN13420 Oglemilast 778576-62-8 Oglemilast is a potent PDE4 inhibitor, under clinical studies in the treatment of allergen-induced asthma.
CSN12406 Mirodenafil 862189-95-5 Mirodenafil is a phosphodiesterase type 5 (PDE-5) inhibitor developed for the treatment of erectile dysfunction.
CSN12286 2-Methyl-6-oxo-1,6-dihydro-[3,4'-bipyridine]-5-carbonitrile 2-hydroxypropanoate(1:x) 100286-97-3 Milrinone lactate is a phosphodiesterase 3 (PDE3) inhibitor and a medication used in patients who have heart failure.
CSN11549 Milrinone 78415-72-2 Milrinone is a phosphodiesterase 3 (PDE3) inhibitor with IC50 of 56 nM, it increases intracellular cyclic adenosine monophosphate resulting in improved ventricular function and vasodilation.
CSN13001 Irsogladine maleate 84504-69-8 Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder.
CSN10162 7-(2,3-Dihydroxypropyl)theophylline 479-18-5 Dyphylline, a xanthine derivative, acts as an adenosine receptor antagonist and phosphodiesterase inhibitor, which is used in the treatment of respiratory disorders.
CSN10863 Doxofylline 69975-86-6 Doxofylline is a methylxanthine bronchodilator used to treat asthma, COPD and bronchospasm, whiel the anti-asthmatic effects are mediated primarily through inhibiting the activities of the phosphodiesterase (PDE) enzyme.
CSN12923 6-(4-(1-Cyclohexyl-1H-tetrazol-5-yl)butoxy)-3,4-dihydroquinolin-2(1H)-one 73963-72-1 Cilostazol is a potent cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitor with IC50 of 0.2 μM and inhibitor of adenosine uptake.
CSN10640 Cilomilast 153259-65-5 Cilomilast is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity.
CSN13776 Bay 60-7550 439083-90-6 BAY 60-7550 is a potent PDE2 inhibitor with IC50 values of 2.0 nM (bovine) and 4.7 nM (human), being 50-fold selective for PDE2 compared to PDE1 and greater than 100-fold selective compared to PDE5, PDE3B, PDE4B, PDE7B, PDE8A, PDE9A, PDE10A, and PDE11A.
CSN13740 (S)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione 608141-41-9 Apremilast is a small molecule inhibitor of PDE4 with an IC50 value of 74 nM.
CSN10307 Anagrelide 68475-42-3 Anagrelide is a drug used for the treatment of essential thrombocytosis (ET; essential thrombocythemia), or overproduction of blood platelets, and also has been used in the treatment of chronic myeloid leukemia. It inhibits cyclic AMP phosphodiesterase, as well as ADP- and collagen-induced platelet aggregation.
CSN10308 Anagrelide HCl 58579-51-4 Anagrelide HCl is a drug used for the treatment of essential thrombocytosis (ET; essential thrombocythemia), or overproduction of blood platelets, and also has been used in the treatment of chronic myeloid leukemia. It inhibits cyclic AMP phosphodiesterase, as well as ADP- and collagen-induced platelet aggregation.
CSN13152 Crisaborole 906673-24-3 AN-2728 is a topically administered, boron-containing, anti-inflammatory compound that inhibits PDE4 activity with an IC50 of 0.49 μM and thereby suppresses the release of TNFalpha, IL-12, IL-23 and other cytokines.
CSN10951 5-Amino-[3,4'-bipyridin]-6(1H)-one 60719-84-8 Amrinone is a type 3 pyridine phosphodiesterase inhibitor used in the treatment of congestive heart failure.
CSN10285 1,3-Dimethyl-3,7-dihydro-1H-purine-2,6-dione hemiethane-1,2-diamine salt 317-34-0 Aminophylline is a competitive nonselective phosphodiesterase inhibitor that is used to treat airway obstruction from asthma or COPD.
CSN13179 (R)-(-)-Rolipram 85416-75-7 (R)-(-)-rolipram, R-enantiomer of rolipram, is a potent and cAMP-specific PDE4 inhibitor with IC50 of 0.22 μM and 2.5-fold more potent than(+)-rolipram (IC50= 2.58 μM) in inhibiting membrane-bound PDE 4.
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