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PDE
货号 | 产品名 | CAS号 | 信息 |
---|---|---|---|
CSN18545 | TP-10 | 898563-00-3 | TP-10 is a PDE10A inhibitor with IC50 of 0.8 nM. |
CSN20597 | TAK-915 | 1476727-50-0 | TAK-915 is a highly potent, selective, and brain-penetrating phosphodiesterase 2A inhibitor with an IC50 of 0.61 nM, potential for the treatment of cognitive disorders. |
CSN17609 | Balipodect | 1238697-26-1 | TAK-063 is a highly potent, selective and orally active PDE10A inhibitor with IC50 of 0.30 nM, displaying > 15000-fold selectivity over other PDEs. |
CSN16723 | (6R,12aR)-6-(Benzo[d][1,3]dioxol-5-yl)-2-methyl-2,3,12,12a-tetrahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4(6H,7H)-dione | 171596-29-5 | Tadalafil is a PDE5 inhibitor with an IC50 value of 1.8 nM. |
CSN19060 | Sophoflavescenol | 216450-65-6 | Sophoflavescenol is a prenylated flavonol, which shows great inhibitory activity with IC50 of 13 nM against phosphodiesterase 5 (PDE5), and also inhibits RLAR, HRAR, AGE, BACE1, AChE and BChE with IC50s of 0.30 μM, 0.17 μM, 17.89 μg/mL, 10.98 μM, 8.37 μM and 8.21 μM, respectively. |
CSN20290 | Roflupram | 1093412-18-0 | Roflupram is a phosphodiesterase 4 inhibitior which suppresses inflammasome activation through autophagy in microglial cells. |
CSN19040 | R 80123 | 133718-30-6 | R80123 is the Z-isomer of R 79595, is also a highly selective phosphodiesterase inhibitor. |
CSN18427 | Pimobendan HCl | 77469-98-8 | Pimobendan HCl is a selective inhibitor of PDE3 with IC50 of 0.32 μM. |
CSN19047 | PF-8380 HCl | 2070015-01-7 | PF-8380 HCl is a potent and specific autotaxin inhibitor with an IC50 value of 2.8 nM. |
CSN19059 | Mardepodect HCl | 2070014-78-5 | PF-2545920 is a potent and selective PDE10A inhibitor with IC50 of 0.37 nM, with > 1000-fold selectivity over the PDE. |
CSN20250 | PF-05085727 | 1415637-72-7 | PF-05085727 is a potent, selective, and brain penetrant phosphodiesterase 2A inhibitor to potentiate NMDA signaling and their further development for clinical cognition indications. |
CSN19049 | PF-04957325 | 1305115-80-3 | PF-04957325 is a highly potent and selective PDE8 inhibitor, with IC50 values of 0.7 nM for PDE8A and less than 0.3 nM for PDE8B. |
CSN13921 | Edelinontrine | 1082744-20-4 | PF-04447943 is a potent, selective brain penetrant PDE9 inhibitor (Ki of 2.8, 4.5 and 18 nM) for human, rhesus and rat recombinant PDE9 respectively and high selectivity for PDE9 versus PDEs1-8 and 10-11. |
CSN20421 | PDE5 Inhibitor C2 | 2109805-65-2 | PDE5 inhibitor C2, a chromeno[2,3-c]pyrrol-9(2H)-one derivate, is a selective and orally bioavailable phosphodiesterase 5 inhibitor for the treatment of pulmonary arterial hypertension. |
CSN13932 | PDE10-IN-1 | 1516896-09-5 | PDE10-IN-1 is a potent PDE10 inhibitor for treating CNS and metabolic disorders. |
CSN17450 | PDE-9 inhibitor | 1082743-70-1 | PDE-9 inhibitor is useful for neurodegenerative diseases. |
CSN22482 | PAT-505 | 1782070-22-7 | PAT-505 is a potent, selective, noncompetitive and orally available autotaxin inhibitor, with an IC50 of 2 nM in Hep3B cells, 9.7 nM in human blood and 62 nM in mouse plasma. |
CSN15931 | Nortadalafil | 171596-36-4 | Nortadalafil is demethyl tadalafil, which is a PDE5 inhibitor, currently marketed in pill form for treating erectile dysfunction (ED) and pulmonary arterial hypertension. |
CSN14435 | Moracin M | 56317-21-6 | Moracin M is a phytoalexin and inhibits PDE4D2, PDE4B2, PDE5A1, and PDE9A2 with the IC(50) values of 2.9, 4.5, > 40, and > 100 μM, respectively. |
CSN18486 | Mirodenafil 2HCl | 862189-96-6 | Mirodenafil 2HCl is a phosphodiesterase type 5 (PDE-5) inhibitor developed for the treatment of erectile dysfunction. |
CSN18660 | 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one | 491-70-3 | Luteolin is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Kis of 15.0/6.4/13.9/11.1/9.5 μM, respectively, it is a flavonoid found in Terminalia chebula. |
CSN17982 | (6AR,9aS)-2-(4-(6-fluoropyridin-2-yl)benzyl)-5-methyl-3-(phenylamino)-5,6a,7,8,9,9a-hexahydrocyclopenta[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(2H)-one phosphate | 1642303-38-5 | ITI-214 is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters, and ion channels, exhibits potent PDE1 inhibitory activity (Ki = 58 pM). |
CSN17506 | (6AR,9aS)-2-(4-(6-Fluoropyridin-2-yl)benzyl)-5-methyl-3-(phenylamino)-5,6a,7,8,9,9a-hexahydrocyclopenta[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(2H)-one | 1160521-50-5 | ITI-214 free base is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters, and ion channels, exhibits potent PDE1 inhibitory activity (Ki = 58 pM). |
CSN16764 | Irsogladine | 57381-26-7 | Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder. |
CSN22159 | ICI 153110 | 87164-90-7 | ICI 153110 is an orally active phosphodiesterase inhibitor with both vasodilating and inotropic properties which is designed for the treatment of congestive cardiac failure. |
CSN19464 | 5-Hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one | 489-32-7 | Icariin is a cGMP-specific PDE5 inhibitor with IC50 of 0.432 μM, 167-fold selective for PDE5 than PDE4 and exhibits multiple biological properties, including anti-inflammatory, neuroregulatory and neuroprotective activities. It is a major constituent of flavonoids from the Chinese medicinal herb Epimedium brevicornum.. |
CSN19387 | 3-Isobutyl-1-methyl-3,7-dihydro-1H-purine-2,6-dione | 28822-58-4 | IBMX is a competitive nonselective PDEs inhibitor and a nonselective adenosine receptor antagonist, with IC50 of 2-50 μM but does not inhibit PDE8 or PDE9. |
CSN16998 | HA130 | 1229652-21-4 | HA130 is a selective ATX (autotaxin) inhibitor with IC50 of 28 nM. |
CSN20418 | GW4869 | 6823-69-4 | GW4869 2HCl is a cell permeable, selective and non-competitve inhibitor of N-SMase (neutral sphingomyelinase), which is important in the metabolism of sphingomyelin producing ceramide and phosphocholine and in cell signaling and regulation. GW4869 is an exosome inhibitor. |
CSN16026 | GSK256066 | 801312-28-7 | GSK256066 is a selective PDE4B (equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, showing > 380,000-fold selectivity versus PDE1/2/3/5/6 and > 2500-fold selectivity against PDE4B versus PDE7. |
CSN17816 | GSK256066 Trifluoroacetate | 1415560-64-3 | GSK256066 is a selective PDE4B (equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, > 380,000-fold selectivity versus PDE1/2/3/5/6 and > 2500-fold selectivity against PDE4B versus PDE7. |
CSN19695 | Ziritaxestat | 1628260-79-6 | GLPG1690, a first-in-class autotaxin (ATX) inhibitor with IC50 of 131 nM and Ki of 15 nMl, is able to cause a sustained reduction of LPA levels in plasma in vivo and was shown to be efficacious in a bleomycin-induced pulmonary fibrosis model in mice, and in reducing extra-cellular matrix deposition in the lung whilst also reducing LPA 18:2 content in bronchoalveolar lavage fluid and may be a possible effectvie compound in treating idiopathic pulmonary fibrosis. |
CSN17233 | TBA-7371 | 1494675-86-3 | DprE1-IN-1, a potent DprE1 inhibitor, with ic50 of 10 nM, also inhibits PDE6, with IC50 of 6 μM. |
CSN16408 | Dipyridamole | 58-32-2 | Dipyridamole is a phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. |
CSN17863 | Deltarasin | 1440898-61-2 | Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ. |
CSN17864 | Deltarasin trihydrochloride | 1440898-82-7 | Deltarasin HCl is a small molecule inhibitor which can inhibit the KRAS-PDEδ interaction (Kd= 41 nM. |
CSN22760 | Cilostamide | 68550-75-4 | Cilostamide is a selective inhibitor of type III phosphodiesterase (PDE3). |
CSN22201 | CI-1044 | 197894-84-1 | CI-1044 is an orally active PDE4 inhibitor with IC50s of 0.29, 0.08, 0.56, 0.09 μM for PDE4A5, PDE4B2, PDE4C2 and PDE4D3, respectively. |
CSN20279 | Tanimilast | 1239278-59-1 | CHF-6001 is a PDE4 inhibitor designed for treating pulmonary inflammatory diseases via inhaled administration. |
CSN21529 | BRL-50481 | 433695-36-4 | BRL-50481 is an inhibitor of PDE7 with IC50 of 0.15 μM and can also inihibt PDE7A, PDE7B, PDE4 and PDE3. BRL-50481 has been shown to increase mineralisation activity in osteoblasts thus has the potential treatment of osteoporosis. |
CSN22709 | BC11-38 | 686770-80-9 | BC 11-38 is a selective phosphodiesterase (PDE) 11 inhibitor with IC50 of 0.28 μM. |
CSN13812 | Avanafil | 330784-47-9 | Avanafil is a potent and highly selective phosphodiesterase-5 (PDE-5) inhibitor with IC50 of 5.2 nM for erectile dysfunction, exhibiting lower selectivity against PDE1, PDE6, and PDE11. |
CSN17534 | AN3199 | 1187187-10-5 | AN-3199 is a PDE4 inhibitor with IC50 of 94.5 nM. |
CSN19826 | 4-((1-Hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)oxy)phthalonitrile | 906673-33-4 | AN-2898 is a potent and selective PDE4 inhibitor potentially for the treatment of fungal infection. |
CSN22345 | AMG 579 | 1227067-61-9 | AMG 579 is a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A) with an IC50 of 0.1 nM. |
CSN22636 | (S)-C33 | 2066488-39-7 | (S)-C33 is a potent PDE9 inhibitor with IC50 of 11 nM. |
CSN17008 | (S)-4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one | 85416-73-5 | (S)-(+)-Rolipram is a PDE4-inhibitor and an anti-inflammatory agent, less potent than its R-enantiomer. |
CSN64503 | 1-(2-Isopropylpyrazolo[1,5-a]pyridin-3-yl)-2-methylpropan-1-one | 50847-11-5 | |
CSN52455 | 5-(2-Ethoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one methanesulfonate | 1308285-21-3 |