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Neurological Disease

货号 产品名 CAS号 信息
CSN18277 Vipadenant 442908-10-3 Vipadenant is an adenosine antagonist with Ki of 1.3 nM and 68 nM for A2A and A1, respectively. Vipadenant is a selective A2A receptor antagonist with Ki values of 1.3, 68, 63, and 1,005 nM for A2A, A1, A2B, and A3 receptors, respectively, used in development for for Parkinson's disease.
CSN18285 Idalopirdine HCl 467458-02-2 Lu AE58054 HCl is an anti-Alzheimer's agent with serotonin 5-HT6 receptor antagonist effect Ki value of 0.83 nM.
CSN18338 Etifoxine HCl 56776-32-0 Etifoxine HCl is a potentiator of β2 or β3 subunit-containing GABAA receptor that promotes axonal regeneration. It shows anxiolytic activity with no effects.
CSN18546 A 438079 HCl 899431-18-6 A 438079 HCl is a competitive P2X7 receptor antagonist (pIC50 = 6.9 for the inhibition of Ca2+ influx in the human recombinant P2X7 cell line).
CSN18554 Pitolisant HCl 903576-44-3 Pitolisant HCl is an inverse agonist of human H3 receptor with Ki of 0.16 nM.
CSN18575 Lorediplon 917393-39-6 Lorediplon, non-benzodiazepine hypnotic drug, acts as a modulator of GABAA receptor with the effect of promoting sleep.
CSN18640 A-836339 959746-77-1 A-836339 is a cannabinoid CB2 receptor-selective agonist and exhibits high potencies at CB(2) and selectivity over CB(1) receptors.
CSN18662 N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride 2508-72-7 Antazoline HCl is a antihistamine with anticholinergic properties. It is used to relieve nasal congestion.
CSN18291 A-317491 475205-49-3 A-317491 is a potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors with Ki values of 22 nM and 9 nM for human P2X3 and P2X2/3 receptors.
CSN18381 LDN-57444 668467-91-2 LDN-57444 is a reversible inhibitor of UCHL1 with IC50 of 0.88 μM (Ki = 0.4 μM) and its selectivity is better than UCH-L3 (IC50 = 25 μM).
CSN18582 Opicapone 923287-50-7 Opicapone is a long-acting, peripherally selective inhibitor of catechol-O-methyltransferase.
CSN18592 Milnacipran 92623-85-3 Milnacipran is a serotonin-norepinephrine reuptake inhibitor (SNRI) used in the clinical treatment of fibromyalgia.
CSN18415 SKF-82958 hydrobromide 74115-01-8 SKF-82958 hydrobromide is a D1/D5 receptor full agonist.
CSN18418 PRE-084 HCl 75136-54-8 PRE-084 HCl is a high affinity, selective σ1 agonist, has an IC50 of 44 nM in the sigma receptor assay.
CSN18619 SMER18 944153-47-3 SMER18 is a small molecule enhancer of rapamycin which act as a mTOR-independent autophagy inducer.
CSN18386 K 01-162 677746-25-7 K 01-162 binds and destabilizes AβO (β-amyloid), with an EC50 of 80 nM.
CSN18594 Bavisant 929622-08-2 Bavisant is a highly selective, orally active antagonist of the human H3 receptor with a mechanism of action, involving wakefulness and cognition, with potential as a treatment for ADHD.
CSN18420 Moxonidine HCl 75536-04-8 Moxonidine HCl is a selective agonist at the imidazoline receptor subtype 1, used as antihypertensive agent.
CSN18441 4-Amino-N-((1-ethylpyrrolidin-2-yl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide hydrochloride 81342-13-4 Amisulpride HCl is an antipsychotic drug, which is a selective dopamine antagonist (Ki=2.8 nM D2 receptor; Ki=3.2 nM D3 receptor).
CSN18395 BoNT-IN-1 694443-03-3 BoNT-IN-1 is a potent inhibitor of Botulinum neurotoxin A light chain (BoNTA LC) with IC50 of 0.9 μM.
CSN18595 Bavisant dihydrochloride 929622-09-3 Bavisant HCl is a highly selective, orally active antagonist of the human H3 receptor with a mechanism of action, involving wakefulness and cognition, with potential as a treatment for ADHD.
CSN18457 GSK163090 844903-58-8 GSK163090 is a potent, selective, and orally active 5-HT1A/B/D receptor antagonist with pKi of 9.4/8.5/9.7, and 6.3/6.7 for dopamine D2/D3, respectively.
CSN18296 CIQ 486427-17-2 CIQ is a subunit-selective potentiator of NMDA receptors containing the NR2C or NR2D subunit.
CSN18318 Methoxy-PEPy 524924-76-3 Methoxy-PEPy is a potent and highly selective mGlu5 receptor antagonist with IC50 of 1 nM.
CSN18653 Telotristat 1033805-28-5 Telotristat is an active metabolite of LX1606, which is an inhibitor of tryptophan hydroxylase.
CSN18262 Amitifadine hydrochloride 410074-74-7 Amitifadine HCl is a triple reuptake inhibitor (TRI) or serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI).
CSN18378 3-(2-(4-(6-Fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)ethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one hydrochloride 666179-74-4 Risperidone HCl is a serotonin 5-HT2 receptor blocker (Ki= 0.16 nM) and a potent dopamine D2 receptor antagonist (Ki= 1.4 nM).
CSN18667 GSK-2881078 1539314-06-1 GSK 2881078 is a selective androgen receptor modulator potentially for the treatment of cachexia.
CSN18390 Zonisamide sodium 68291-98-5 Zonisamide sodium is a 1,2 benzisoxazole derivative and the first agent of this chemical class to be developed as an antiepileptic drug.
CSN18631 N-[(4-Aminophenyl)methyl]adenosine 95523-13-0 N-[(4-Aminophenyl)methyl]adenosine is an adenosine receptor inhibitor, with Ki of 29 nM for rat ecto-5′-nucleotidase.
CSN18512 Dipraglurant 872363-17-2 Dipraglurant is a mGluR5 antagonists with IC50 of 0.021 μM.
CSN18450 Agomelatine (L(+)-Tartaric acid) 824393-18-2 Agomelatine L(+)-tartaric acid is an antidepressant, which is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor.
CSN18624 RN-1734 946387-07-1 RN-1734 is selective antagonist of the TRPV4 channel, completely antagonizes 4αPDD-mediated activation of TRPV4 with comparable, low micromolar IC50 values for all three species (hTRPV4: IC50 = 2.3 μM, mTRPV4: IC50 = 5.9 μM, rTRPV4: IC50 = 3.2 μM).
CSN18286 Idalopirdine 467459-31-0 Lu AE58054 is an in-vitro potency and selectivity, in-vivo binding affinity and effect of the 5-HT(6)R antagonist with a Ki value of 0.83 nM.
CSN18379 Risperidone mesylate 666179-96-0 Risperidone mesylate is a serotonin 5-HT2 receptor blocker (Ki= 0.16 nM) and a potent dopamine D2 receptor antagonist (Ki= 1.4 nM).
CSN18541 APNEA 89705-21-5 N6-[2-(4-Aminophenyl)ethyl]adenosine is a potent, non-selective A3 adenosine receptor agonist.
CSN18478 Setiptiline maleate 85650-57-3 Setiptiline is a serotonin receptor antagonist.
CSN18439 Notoginsenoside R2 80418-25-3 Notoginsenoside R2 is a notoginsenoside from Panax notoginseng, showed neuroprotective effects against 6-OHDA-induced oxidative stress and apoptosis.
CSN18659 Lanabecestat 1383982-64-6 AZD3293 is an oral beta-secretase 1 cleaving enzyme (BACE) inhibitor.
CSN18672 CGS-9896 77779-36-3 CGS-9896 is an anxiolytic drug used in scientific research.
CSN18253 Tarafenacin 385367-47-5 Tarafenacin is a highly selective M3 muscarinic receptor antagonist (Ki= 0.19 nM), ~200 fold selectivity over M2 receptor.
CSN18368 Azaphen 2HCl 63302-99-8 Pipofezine is a potent inhibitor of the reuptake of serotonin.
CSN18435 JDTic 2HCl 785835-79-2 JDTic 2HCl is a highly selective antagonist for the κ-opioid receptor without affecting the μ- or δ-opioid receptors.
CSN18547 A 438079 899507-36-9 A 438079 is a competitive P2X7 receptor antagonist (pIC50 = 6.9 for the inhibition of Ca2+ influx in the human recombinant P2X7 cell line).
CSN18509 A 839977 870061-27-1 A-839977 is a selective P2X7 antagonist and blocks BzATP-evoked calcium influx at recombinant human, rat and mouse P2X7 receptors (IC50 values are 20, 42 and 150 nM respectively).
CSN18536 LDN-212320 894002-50-7 LDN-212320 is a glutamate transporter EAAT2 activator and enhances EAAT2 levels by > 6 fold at concentrations < 5 μM after 24 h.
CSN18608 gamma-Secretase Modulators 937812-80-1 gamma-Secretase modulators is an Amyloid-β production inhibitor, useful for Alzheimer's disease.
CSN18369 N-(2-(4-(2-Methoxyphenyl)piperazin-1-yl)ethyl)-N-(pyridin-2-yl)cyclohexanecarboxamide xmaleate 634908-75-1 WAY-100635 Maleate is both a potent and silent antagonist of 5-HT1A receptors with IC50 value of 2.2 nM and an agonist of dopamine D4 receptors.
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