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Neurological Disease

货号 产品名 CAS号 信息
CSN18852 MK-1064 1207253-08-4 MK-1064 is a selective orexin 2 receptor antagonist(2-SORA) for the research of insomnia.
CSN18999 Hypidone HCl 1339058-04-6 YL0919 is a dual 5-HT1A partial agonist and SSRI, producing antidepressant- and anxiolytic-like effects.
CSN19021 Suvecaltamide 953778-58-0 MK-8998 is a potent and selective antagonist of the T-typecalcium channel.
CSN19022 Mirogabalin 1138245-13-2 Mirogabalin is a preferentially selective α2δ-1 ligand characterized by high potency and selectivity to the α2δ-1 subunit of voltage-sensitive calcium channel complexes in the CNS.
CSN19031 U93631 152273-12-6 U93631 is a ligand of GABAA receptor ligand (IC50 = 100 nM) which can induce a rapid decay of GABA-induced chloride currents.
CSN19034 Basmisanil 1159600-41-5 Basmisanil is a selective modulator of GABAAα5 with negative allosteric regulation.
CSN19185 Hydroxy-Dynasore 1256493-34-1 Hydroxy Dynasore is an inhibitor of dynamin1 and dynamin2 with IC50 of 0.38 μM and 2.6 µM respectively. It can prevent dynamin-mediated endocytosis in multiple cell types.
CSN18718 trans-2-Phenylcyclopropanamine hydrochloride 1986-47-6 Tranylcypromine is a dual inhibitor of both MAO-A/B and LSD1.
CSN18684 Tribromoethyl alcohol 75-80-9 2,2,2-Tribromoethanol is used as an injectable anesthetic agent in mice.
CSN18775 Chlorprothixene 113-59-7 Chlorprothixene is an antagonist of multiple receptors including 5-HT2 (Ki = 3.4 nM), D1 (Ki = 18 nM), D2 (Ki = 18 nM), D3 (Ki = 4.56 nM), H1 (Ki = 3.75 nM), muscarinic acetylcholine receptors, α1-Adrenergic.
CSN18745 Lofexidine HCl 21498-08-8 Lofexidine HCl is an α2A-adrenergic receptor agonist, commonly used to alleviate the physical symptoms of heroin and other types of opioid withdrawal.
CSN19030 IC87201 866927-10-8 IC87201, an inhibitor of PSD95-nNOS protein-protein interactions, suppresses NMDAR-dependent NO and cGMP formation.
CSN18778 2-(Diethylamino)ethyl 3-amino-4-propoxybenzoate hydrochloride 5875-06-9 Proparacaine HCl is an antagonist of voltage-gated sodium channels with ED50 of 3.4 mM.
CSN18682 CGS 21680 HCl 124431-80-7 CGS 21680 HCl is A2A adenosine receptor agonist with Ki value of 27 nM, which can be used to distinguish A2A- and A2B-mediated effect and shows affinity for both A1 and A3 adenosine receptors.
CSN18709 Flopropione 2295-58-1 Flopropione is both a 5-HT1A receptor antagonist and a COMT inhibitor as a spasmolytic or antispasmodic agent.
CSN18740 Verubecestat 1286770-55-5 Verubecestat is a BACE1 inhibitor. MK-8931 binds significantly to β-secretase.
CSN18679 Zonisamide 68291-97-4 Zonisamide, a 1,2 benzisoxazole derivative, is developed as an antiepileptic drug.
CSN18990 Cetrorelix Acetate 145672-81-7 Cetrorelix acetate is a potent gonadotropin-releasing hormone (GnRH) receptor antagonist with IC50 of 1.21 nM.
CSN18994 GSK189254A 720690-73-3 GSK189254A is a potent and selective histamine H3 receptor antagonist with pKi values of 9.59-9.90 and 8.51-9.17 for human and rat H3, respectively.
CSN18977 JNJ16259685 409345-29-5 JNJ16259685 is a selective antagonist at the mGlu1 receptors, and inhibits the synaptic activation of mGlu1 in a concentration-dependent manner with IC50 of 19 nM.
CSN18707 Rizatriptan benzoate 145202-66-0 Rizatriptan Benzoate is a triptan-class 5-HT1 receptor agonist, used to treat migraine headaches.
CSN19004 Epiberberine chloride 889665-86-5 Epiberberine chloride, a natural alkaloid, is a BACE1 inhibitor, which also exhibits inhibition activity on CYP2D6 and aldose reductase, alpha-adrenoceptors, acetylcholinesterase (AChE), butyrylcholinesterase, and b-site amyloid precursor protein cleaving enzyme 1.
CSN19128 amyloid P-IN-1 1819986-22-5 Amyloid P-IN-1 is a potential compound for treating amyloidosis, Alzheimer's disease, type 2 diabetes mellitus and osteoarthritis.
CSN19217 740 Y-P 1236188-16-1 740 Y-P is cell-permeable peptide activator of PI3K.
CSN19065 BMS 299897 290315-45-6 BMS 299897 is an orally active, potent γ-secretase inhibitor (IC50 = 12 nM).
CSN19029 ZL006 1181226-02-7 ZL006 is a potent inhibitor of nNOS/PSD-95 interaction, and inhibits NMDA receptor-mediated NO synthesis.
CSN19266 CP-809101 479683-64-2 CP-809101 is a potent and selective 5-HT2C receptor agonist with pEC50 of 9.96/7.19/6.81 for human 5-HT2C/5-HT2B/5-HT2A receptors respectively.
CSN19062 TB5 948841-07-4 TB5 is a potent, selective and reversible inhibitor ofhMAO-Bwith aKivalue of 0.11±0.01 μM.
CSN19041 GNF-PF-3777 77603-42-0 8-Nitrotryptanthrin is a potent human indoleamine 2,3-dioxygenase 2 (hIDO2) inhibitor which significantly reduces IDO2 activity with Ki of 0.97 μM.
CSN18975 Ro 67-7476 298690-60-5 Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors.
CSN18853 FGFR4-IN-1 1708971-72-5 FGFR4-IN-1 is a potent inhibiotr of FGFR4 with IC50 of 0.7 nM.
CSN19028 Podocarpic acid 5947-49-9 Podocarpic acid is a natural product, which has the best all-round positive effect and acts as a TRPA1 activator.
CSN19265 SB 242084 181632-25-7 SB-242084 is a 5-HT2C receptor antagonist (pKi=9.0) that displays 158- and 100-fold selectivity over 5-HT2A and 5-HT2B receptors respectively.
CSN19002 (+)-Cevimeline hydrochloride hemihydrate 1462862-74-3 (+)-Cevimeline HCl, a muscarinic receptor agonist, is a candidate therapeutic drug for xerostomia in Sjogren's syndrome.
CSN18749 Piribedil 3605-01-4 Piribedil is an antiparkinsonian agent and piperazine derivative which acts as a D2 and D3 receptor agonist.
CSN18747 Benzetimide HCl 5633-14-7 Benzetimide HCl is a muscarinic acetylcholine receptor antagonist.
CSN18717 Ethyl 4-aminobenzoate hydrochloride 23239-88-5 Benzocaine HCl is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.
CSN18823 Olodanrigan 1316755-16-4 EMA401, a highly selective AT2R antagonist, inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation, and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons.
CSN18902 GNE-7915 tosylate 2070015-00-6 GNE-7915 tosylate is a potent, selective and brain-penetrant inhibitor of LRRK2 with an IC50 of 9 nM.
CSN18939 Pimelic Diphenylamide 106 (analog) 2070015-24-4 Pimelic diphenylamide 106 Analog is an analog of Pimelic Diphenylamide 106 with unknown biological activity. Pimelic Diphenylamide 106 is a class I HDAC inhibitor, demonstrating no activity against class II HDACs. 106 is a slow, tight-binding inhibitor of HDACs 1, 2, and 3 with preference toward HDAC3 with Ki of approximately 14 nm, 15 times lower than the Ki for HDAC1.
CSN19003 (-)-Cevimeline hydrochloride hemihydrate N/A (-)-Cevimeline HCl, a muscarinic receptor agonist, is a candidate therapeutic drug for xerostomia in Sjogren's syndrome.
CSN18998 DREADD agonist 21 56296-18-5 DREADD agonist 21 is a potent muscarinic DREADD agonist with pEC50 values of 8.91, 8.48 and 7.77 for hM1Dq, hM3Dq and hM4Di, respectively.
CSN19024 A-317491 sodium salt hydrate N/A A-317491 sodium is a non-nucleotide P2X3 and P2X2/3 receptor antagonist, which inhibits calcium flux mediated by the receptors.
CSN19272 PEAQX tetrasodium hydrate N/A PEAQX is a potent and orally active NMDA antagonist with a 15-fold preference for human NMDA receptors with the 1A/2A (IC50=270 nM), rather than 1A/2B(29,600 nM).
CSN18831 N-(2-(4-(2-Methoxyphenyl)piperazin-1-yl)ethyl)-N-(pyridin-2-yl)cyclohexanecarboxamide Maleate 1092679-51-0 WAY-100635 fumarate is a potent and selective 5-HT receptor antagonist with IC50 of 0.95 nM.
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