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Neurological Disease

货号 产品名 CAS号 信息
CSN20266 BIA 10-2474 1233855-46-3 BIA10-2474 is an inhibitor of fatty acid amide hydrolase (FAAH) with IC50 of 4.9 nM.
CSN20356 BQCA 338747-41-4 BQCA is a highly selective allosteric potentiator of the M1 mAChR and reduces the concentration of ACh required to activate M1 up to 129-fold with an inflection point value of 845 nM.
CSN20444 ICA-069673 582323-16-8 ICA 069673 selectively inhibit KV7.2 (KCNQ2) and KV7.3 (KCNQ3) channel with EC50 of 0.69 μM and has no measurable activity over a panel of cardiac ion channels.
CSN20458 WAY-200070 440122-66-7 WAY200070 selectively activates ERβ (EC50 = 2 nM) receptor over ERα (EC50 = 155 nM). It shows anti-depressive and anti-anxiolytic activities.
CSN20476 Pitofenone 54063-52-4 Pitofenone an AChE inhibitor with Ki values of 36 and 45 μM for bovine erythrocyte and electric eel enzyme, which shows anti-spasmodic activity in combination with Fenpiverinium and Diclofenac.
CSN20479 ST034307 133406-29-8 ST034307 is an adenylyl cyclase 1 (AC1) inhibitor (IC50 = 2.3 μM), which exhibits some selectivity for AC1 over other AC isoforms.
CSN20514 AUTEN-99 HBr 1049780-58-6 Auten-99 is an inhibitor of the myotubularin phosphatase Jumpy (also called MTMR14), acrossing the blood-brain barrier and exerting potent neuroprotective effects.
CSN20529 BP 897 HCl 314776-92-6 BP897 is a partially selective dopamine D3 receptor agonist (Ki = 0.92 nM) that developed for the study of cocaine addiction.
CSN20577 Ocaperidone 129029-23-8 Ocaperidone is a benzisoxazole is an antagonist of both 5HT and D2 receptors.
CSN20416 ISRIB 548470-11-7 trans-ISRIB is an Integrated Stress Response Inhibitor. trans-ISRIB inhibits the eIF2α phosphorylation-mediated unfolded protein response following induction of ER stress (IC50 = 5 nM in a cell-reporter assay).
CSC20416 ISRIB 548470-11-7
CSN20652 ML402 298684-44-3 ML402 is a selective TREK-1 activator.
CSN20615 PF-05105679 1398583-31-7 PF-05105679 is an orally-bioavailable and selective TRPM8 blocker (IC50 = 103 nM) which exhibits > 100-fold selectivity for TRPM8 over a panel of receptors, ion channels and enzymes, including TRPV1 and TRPA1 ion channels.
CSN20430 ACT-462206 1361321-96-1 ACT-462206 is a potent and brain-penetrant dual orexin receptor antagonist (IC50 values are 11 and 60 nM for OX2 and OX1 receptors respectively), and it exhibits anxiolytic-like properties in vivo.
CSN20599 S38093 HCl 1222097-72-4 S 38093 is an inverse agonist of H3 receptor.
CSN20235 2-D08 144707-18-6 2-D08 interacts with amyloid β, showing an anti-aggregatory and neuroprotective effect.
CSN20304 PE859 1402727-29-0 PE859 is a Curcumin-derived inhibitor of Amyloid-β and Tau aggregation and can ameliorate cognitive dysfunction in senescence-accelerated mouse Prone 8.
CSN20601 Aticaprant 1174130-61-0 LY-2456302 is a potent and centrally-penetrant kappa opioid receptor antagonist with a Ki of 0.807 nM.
CSN20437 LP-211 1052147-86-0 P-211 is an a selective agonist of the serotonin 5-HT7 receptor with a Ki value of 0.58 nM at rat cloned 5-HT7 receptors, and > 300-fold selectivity over the 5-HT1A receptor.
CSN20381 Ulixacaltamide 1199236-64-0 Z944 is a T-type calcium channel antagonist potentially for the treatment of pain. Z944 disrupts prepulse inhibition in both epileptic and non-epileptic rats.
CSN20273 Ro60-0175 fumarate 169675-09-6 Ro 60-0175 is a 5HT2C receptor agonist.
CSN20353 RS 67333 HCl 168986-60-5 RS-67333 HCl is a potent and highly selective 5-HT4 partial agonist, with pKi values of 8.7 at 5-HT4 sites in guinea pig striatum and > 6 at various other receptors, including 5-HT1A, 1D, 2A, 2C, D1, D2 and M1-3. It is also active in vivo, with an intrinsic activity relative to 5-HT of 0.5.
CSN20527 Pinaverium bromide 53251-94-8 Pinaverium bromide acts as a calcium channel blocker in helping to restore the normal contraction process of the bowel.
CSN20415 SKF 83959 HBr 67287-95-0 SKF 83959 hydrobromide is a dopamine D1-like receptor partial agonist (Ki values are 1.18, 7.56, 920 and 399 nM for rat D1, D5, D2 and D3 receptors respectively). It may act as an antagonist in vivo, producing anti-Parkinsonian effects and antagonizing the behavioral effects of cocaine.
CSN20462 E-6837 528859-61-2 E-6837 is an orally active, 5-HT6 agonist developed in an attempt to create an anti-obesity medication.
CSN20432 Seltorexant 1293281-49-8 Seltorexant is a selective orexin-2 receptor antagonist that has been shown to promote sleep in various species.
CSN20424 PD-149163 169528-11-4 PD149163, a neurotensin receptor 1 agonist, decreases methamphetamine self-administration in DBA/2J mice without causing excessive sedation.
CSN20500 STO-609 acetate 1173022-21-3 STO-609 acetate is a cell-permeable inhibitor of calcium/calmodulin-dependent kinase kinases (CaMKK) isoforms CaMKKα and CaMKKβ (Ki = 80 and 15 ng/mL, respectively).
CSN20484 PF-06827443 2115022-67-6 PF-06827443 is an otent, low clearance, orally bioavailable, and CNS penetrant muscarinic M1-selectivepositive allosteric modulator (PAM) with minimal agonist activity.
CSN20509 Trk Inhibitor C11 1614229-04-7 Trk inhibitor C11 is an orally active pan-Trk inhibitor showing efficacy in both inflammatory and neropathic pain models.
CSN20387 TC-6683 1025007-04-8 AZD1446 is a highly selective α4β2 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders.
CSN20510 LY3130481 1610802-47-5 LY3130481 is the the first α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist that is dependent on the presence of TARP γ-8. LY3130481 is fully protective against pentylenetetrazole-induced convulsions in rats without the motor impairment associated with non-TARP-dependent AMPA receptor antagonists.
CSN20365 Sembragiline 676479-06-4 Sembragiline is a selective monoamine oxidase type B inhibitor for the treatment of Alzheimer's disease.
CSN20263 Nelonicline 1026134-63-3 ABT-126 is an alpha7 nicotinic acetylcholine receptor agonist and nicotinic acetylcholine receptor agonist. Nelonicline is potentially useful for the treatment of Alzheimer's diseases. ABT-126 may be useful to reduce dyskinesias in both early- and later-stage Parkinson's disease.
CSN20250 PF-05085727 1415637-72-7 PF-05085727 is a potent, selective, and brain penetrant phosphodiesterase 2A inhibitor to potentiate NMDA signaling and their further development for clinical cognition indications.
CSN20330 CB2 Agonist C8 2052602-31-8 CB2 agonist C8 is an agonists of cannabinoid receptor type 2.
CSN20331 CB2 Agonist C36 2097512-96-2 CB2 agonist C36 is an agonists of cannabinoid receptor type 2.
CSN20313 Befiradol 208110-64-9 NLX-112 is a potent and efficacious serotonin 5-HT1A receptor agonist potentially for the treatment of drug-induced dyskinesia in patients.
CSN20581 ASP7663 1190217-35-6 ASP 7663 is an orally-bioavailabe, selective TRPA1 activator (EC50 values are ~0.5 μM in human, mouse and rat), which displays little or no affinity at more than 60 other related receptors, channels and enzymes. It stimulates 5-HT release from QGP-1 cells and exhibits an abdominal analgesic effect in vivo.
CSN20584 Clobenpropit 2HBr 145231-35-2 Clobenpropit hydrobromide is a selective histamine H3 receptor antagonist that crosses the blood-brain barrier, inhibiting histamine binding in rat brain.
CSN20597 TAK-915 1476727-50-0 TAK-915 is a highly potent, selective, and brain-penetrating phosphodiesterase 2A inhibitor with an IC50 of 0.61 nM, potential for the treatment of cognitive disorders.
CSN20613 GSK360A 931399-19-8 GSK360A is an active HIF-PHD inhibitor with systemic and local effects by stabilizing HIF-1α signaling and can improve long-term ventricular function.
CSN20553 PF-06462894 1622291-66-0 PF-06462894 is an alkyne-lacking metabotropic glutamate receptor 5 negative allosteric modulator.
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