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| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN12512 | 5-(4-(2-(Methyl(pyridin-2-yl)amino)ethoxy)benzyl)thiazolidine-2,4-dione | 122320-73-4 | Rosiglitazone is a selective agonist of PPARγ with EC50 of 60 nM, and has no effect on PPARα and PPARβ. It is an insulin sensitizing and potent antihyperglycemic agent. |
| CSN11984 | (2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl (4R,4aS,6aR,9S,11aR,11bS)-9-(((2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-4,11b-dimethyl-8-methylenetetradecahydro-6a,9-methanocyclohepta[a]naphthalene-4-carboxylate | 57817-89-7 | Stevioside, a natural product isolated and purified from the leaves of Stevia rebaudiana, is a safe natural sweetener, has no allergic reactions, suited for both diabetics, and PKU patients, as well as for obese persons intending to lose weight by avoiding sugar supplements in the diet. Stevioside also exerts anti-inflammatory and anti-apoptotic properties by inhibiting the release of cytokines and the activation of TLR2 and proteins of the NF-κB and MAPK signaling pathways, as well as caspase-3 and Bax. Stevioside and steviol attenuate LPS-induced pro-inflammatory cytokine productions by affecting cytokine gene expression via IκBα/NF-κB signalling pathway. |
| CSN12576 | (2'R,4S,5'R,6aR,6bS,8aS,8bR,9S,11aS,12aS,12bS)-5',6a,8a,9-Tetramethyl-1,3,3',4,4',5,5',6,6a,6b,6',7,8,8a,8b,9,11a,12,12a,12b-icosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-pyran]-4-ol | 512-04-9 | Diosgenin, a natural product isolated and purified from the rhizomes of Dioscorea zingiberensis C.H.Wright, is an important natural source of steroidal hormones, and has favorable effects in the improvement of diabetes and regulation of lipid metabolism. |
| CSN12489 | Pioglitazone HCl | 112529-15-4 | Pioglitazone HCl is a selective agonist of PPARγ with EC50 of 0.93 μM which is used to treat diabetes. |
| CSN12570 | Rosiglitazone maleate | 155141-29-0 | Rosiglitazone maleate is the maleate form of rosiglitazone which is a high-affinity selective agonist of the peroxisome proliferator-activated receptor-γ (PPARγ) with Kd of 40 nM and it also acts as a modulator of TRP channels. |
| CSN11697 | Phloretin | 60-82-2 | Phloretin, a dihydrochalcone flavonoid, can inhibit the active transport of glucose into cells by SGLT1 and SGLT2. It is mainly found in fruit and roots of apple tree. |
| CSN11698 | Phlorizin | 60-81-1 | Phlorizin is an inhibitor of hSGLT1 (Ki=300 nM) and hSGLT2 (Ki= 39 nM). It can be found in a number of fruit trees. |
| CSN11865 | Rosuvastatin | 287714-41-4 | Rosuvastatin is a synthetic and highly effective statin-class HMG-CoA reductase inhibitor with IC50 of 11 nM. |
| CSN11927 | Simvastatin | 79902-63-9 | Simvastatin a specific and a lovastatin similar HMG-CoA reductase inhibitor with Ki value of 0.1-0.2 nM, used to treat hypercholesterolemia. |
| CSN11942 | Sodium 4-phenylbutanoate | 1716-12-7 | Sodium 4-phenylbutyrate is an inhibitor of histone deacetylase that has been used to treat urea cycle disorders. |
| CSN11988 | Strontium Ranelate | 135459-87-9 | Strontium ranelate stimulates the calcium sensing receptors (CaSR) and leads to the differentiation of pre-osteoblast to osteoblast which increases the bone formation. |
| CSN12105 | N-(Butylcarbamoyl)-4-methylbenzenesulfonamide | 64-77-7 | Tolbutamide is a potassium channel blocker, sulfonylurea oral hypoglycemic drug. |
| CSN12208 | (S,Z)-3-((E)-2-((1R,3aS,7aR)-1-((2R,5R,E)-5,6-Dimethylhept-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexanol | 50-14-6 | Vitamin D2 selectively inhibits mammalian DNA polymerase A (pol A) with IC50 of 123 mM. |
| CSN12212 | Voglibose | 83480-29-9 | Voglibose, an N-substituted derivative of valiolamine, can inhibit α-glucosidase and be used to treat hyperglycemia and its concomitant diseases. |
| CSN12217 | 2-((4-Chloro-6-((2,3-dimethylphenyl)amino)pyrimidin-2-yl)thio)acetic acid | 50892-23-4 | Wy-14643 is an agonist of PPARα with EC50 of 0.63 μM that can decrease the inflammatory response. It has other functions including lipid metabolism, cell proliferation, differentiation, adipogenesis etc.. |
| CSN12266 | 3-(5-(2-Fluorophenyl)-1,2,4-oxadiazol-3-yl)benzoic acid | 775304-57-9 | PTC-124 is nonsense allele inhibitor, used to treat Duchenne muscular dystrophy. |
| CSN12298 | Pravastatin Sodium | 81131-70-6 | Pravastatin Sodium is a competitive HMG-CoA reductase inhibitor with IC50 value of 5.6 μM. |
| CSN12323 | (R)-8-(3-Aminopiperidin-1-yl)-7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-1H-purine-2,6(3H,7H)-dione | 668270-12-0 | Linagliptin, a purine and quinazoline derivative, can inhibit DPP-4 with IC50 of 1 nM. It functions as an incretin and is used as a hypoglycemic agents in the treatment of type 2 diabetes mellitus. |
| CSN12342 | (2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol | 461432-26-8 | Dapagliflozin is a selective inhibitor of SGLT2 with EC50 of 1.1 nM which is used to treat type 2 diabetes mellitus. |
| CSN12382 | Taranabant | 701977-09-5 | Taranabant is a cannabinoid 1 receptor inverse agonist with IC50 of 0.3 nM. |
| CSN12529 | (3R,5R)-7-(2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoic acid | 134523-00-5 | Atorvastatin is an inhibitor of HMG-CoA reductase used as a cholesterol-lowering medication that blocks the production of cholesterol. |
| CSN12530 | Calcium (3R,5R)-7-(2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate | 134523-03-8 | Atorvastatin Hemicalcium is a potent HMG-CoA reductase inhibitor with IC50 value of 8 nM. |
| CSN12556 | Mitiglinide calcium | 145525-41-3 | Mitiglinide calcium is a blood glucose-lowering drugs, stimulating insulin secretion by closing the ATP-sensitive K+ channels in pancreatic beta-cells. |
| CSN12603 | Ercalcidiol | 21343-40-8 | Ercalcidiol is a metabolite of vitamin D2, is regarded as an indicator of vitamin D nutritional status. |
| CSN12642 | Trimebutine maleate | 34140-59-5 | Trimebutine Maleate is an agonist effect on peripheral μ, k and δ opiate receptors, and also shows antimuscarinic effect. |
| CSN12659 | GW9508 | 885101-89-3 | GW9508 is selective FFA1 (GPR40) agonist with pEC50 of 7.32 and stimulates insulin secretion in a glucose-sensitive manner. |
| CSN12755 | Sitagliptin phosphate | 654671-78-0 | Sitagliptin phosphate is a potent inhibitor of DPP4 with IC50 of 19 nM in Caco-2 cell extracts. |
| CSN12800 | A 922500 | 959122-11-3 | A 922500 is a potent, selective, and orally bioavailable DGAT-1 inhibitor with IC50 values of 7 nM and 24 nM for human and mouse DGAT-1 respectively. |
| CSN11945 | Sodium Butyrate | 156-54-7 | Sodium butyrate is a histone deacetylase (HDAC) inhibitor with IC50s are 0.3 mM, 0.4 mM, 0.3 mM for HDAC1, 2 and 7 respectively. |
| CSN12781 | 2-Aminoethyl carbamimidothioate dihydrobromide | 56-10-0 | 2-(2-Aminoethyl)isothiourea dihydrobromide inhibits nitric oxide synthase (NOS). |
| CSN12209 | Doxercalciferol | 54573-75-0 | Doxercalciferol is a synthetic vitamin D2 analog, suppressing parathyroid synthesis and secretion, used to treat secondary hyperparathyroidism and metabolic bone disease. |
| CSN12250 | Ercalcitriol | 60133-18-8 | Ercalcitriol is an active metabolite of vitamin D2. |
| CSN11655 | Paricalcitol | 131918-61-1 | Paricalcitol is a vitamin D receptor agonist, used for the prevention and treatment of secondary hyperparathyroidism (excessive secretion of parathyroid hormone) associated with chronic renal failure. |
| CSN12023 | Tacalcitol | 57333-96-7 | Tacalcitol promotes normal bone development by regulating calcium. |
| CSN12147 | Trimebutine | 39133-31-8 | Trimebutine is an agonist effect on peripheral μ, k and δ opiate receptors, and also shows antimuscarinic effect. |
| CSN12287 | Vildagliptin | 274901-16-5 | Vildagliptin is an inhibitor of DPP-4 with IC50 of 2.3 nM that is used in the treatment of type 2 diabetes mellitus. |
| CSN11585 | NPS-2143 | 284035-33-2 | NPS-2143 is a selective potent calcium ion-sensing receptor antagonist with IC50 of 43 and 41 nM for cytoplasmic Ca2+ concentrations and parathyroid hormone secretion, respectively. |
| CSN12680 | Isopropyl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoate | 49562-28-9 | Fenofibrate is an agonist of PPARα (EC50 = 30 μM) and an inhibitor of CYP2C19 (IC50 = 0.2 μM) and CYP2B6 (IC50 = 0.7 μM). Fenofibrate is a fibric acid derivative and used to treat hypercholesterolemia and hypertriglyceridemia. |
| CSN11928 | Simvastatin acid ammonium | 139893-43-9 | Simvastatin ammonium is an HMG-CoA reductase inhibitor. |
| CSN12117 | Torcetrapib | 262352-17-0 | Torcetrapib is a CETP inhibitor with IC50 of 37 nM, elevates HDL-C and reduces nonHDL-C in plasma. |
| CSN12155 | Troglitazone | 97322-87-7 | Troglitazone is a PPARγ agonist with EC50 of 780 nM in murine and 555 nM in human. It has no activity at PPARα or PPARδ and can act as an anti-diabetic agent. |
| CSN12558 | Rosuvastatin Calcium | 147098-20-2 | Rosuvastatin Calcium is a competitive and synthetic HMG-CoA reductase inhibitor with IC50 value of 11 nM. |
| CSN12318 | (R)-2-((6-(3-Aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile benzoate | 850649-62-6 | Alogliptin benzoate is the benzoate salt form of alogliptin which is a selective inhibitor of DPP-4 with IC50 of 6.9 nM that exhibits greater selective than DPP-2, DPP-8 and DPP-9. |
| CSN12346 | (1S,3S,5S)-2-((2S)-2-Amino-2-(3-hydroxyadamantan-1-yl)acetyl)-2-azabicyclo[3.1.0]hexane-3-carbonitrile | 361442-04-8 | Saxagliptin is a selective and reversible DPP4 inhibitor with IC50 of 26 nM. |
| CSN12356 | Anacetrapib | 875446-37-0 | Anacetrapib is a potent, selective, reversible rhCETP and mutant CETP (C13S) inhibitor with IC50 of 7.9 nM and 11.8 nM, increases HDL-C and decreases LDL-C, does not increase aldosterone or blood pressure. |
| CSN12799 | T863 | 701232-20-4 | T863 is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis in cells. |
| CSN11972 | SQ22536 | 17318-31-9 | SQ22536 is an inhibitor of adenylyl cyclase with an IC50 of 1.4 μM. It can inhibit PGE1-stimulated increases in cAMP levels in intact human platelets. |
