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| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN17291 | 2-(2-Nitro-4-(trifluoromethyl)benzoyl)cyclohexane-1,3-dione | 104206-65-7 | Nitisinone is an inhibitor of the enzyme 4-hydroxyphenylpyruvate dioxygenase. |
| CSN17332 | Bis(((2S,4S)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-yl)(thiazolidin-3-yl)methanone) pentahydrobromide | 906093-29-6 | Teneligliptin Hydrobromide is a DPP4 inhibitor with IC50 value of <1 nM. It is commonly used as an add on treatment when meformin is not achieving the expected glycemic goals. |
| CSN17473 | (2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-(2-cyclopropoxyethoxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol | 1118567-05-7 | Bexagliflozin is an inhibitor of SGLT2 with IC50 value of 2 nM. |
| CSN17737 | Verinurad | 1352792-74-5 | Verinurad is an inhibitor of urate transporter with EC50 of 0.05 μM. |
| CSN17752 | GNE-617 | 1362154-70-8 | GNE-617 is a potent NAMPT inhibitor with IC50 value of 5nM. |
| CSN18188 | N-(4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl)thiophene-2-sulfonamide | 293753-05-6 | SR3335 can selectively bind to RORα and competitively inhibit the binding of 25-hydroxycholesterol to the ligand binding domain with Ki of 220 nM. |
| CSN18374 | ATN-224 | 649749-10-0 | ATN-224, a copper-chelator agent, can inhibit intracellular SOD1 with IC50 of 17.5 nM. |
| CSN17888 | Ranirestat | 147254-64-6 | Ranirestat is an aldose reductase inhibitor being developed for the treatment of diabetic neuropathy. |
| CSN18211 | NPS-2143 HCl | 324523-20-8 | NPS-2143 HCl is a potent and selective calcium ion-sensing receptor antagonist with IC50 of 43 and 41 nM for cytoplasmic Ca2+ concentrations and parathyroid hormone secretion, respectively. |
| CSN17678 | NB-598 | 131060-14-5 | NB-598 is a potent competitive inhibitor of squalene epoxidase (SE). |
| CSN17452 | LY-2584702 tosylate salt | 1082949-68-5 | LY2584702 tosylate salt is an inhibitor of p70S6K signaling and can prevent the phosphorylation of S6 subunit of ribosomes. |
| CSN17552 | Tofogliflozin (hydrate) | 1201913-82-7 | Tofogliflozin is a potent and highly specific sodium/glucose cotransporter 2(SGLT2) inhibitor with Ki values of 2.9, 14.9, and 6.4 nM for human, rat, and mouse SGLT2. |
| CSN17794 | TUG-770 | 1402601-82-4 | TUG-770 is a highly potent free fatty acid receptor 1 (FFA1/GPR40) agonist with EC50 of 6 nM for hFFA1. |
| CSN17597 | Ampkinone | 1233082-79-5 | Ampkinone is a small molecule activator of AMPK and stimulates functional activation of AMPK via the phosphorylation at Thr172 in cultured L6 muscle cells with an EC50 value of 4.3 μM, enhancing glucose uptake by 3.2-fold. |
| CSN18081 | Balaglitazone | 199113-98-9 | Balaglitazone is a partial agonist of PPAR-γ. |
| CSN17754 | (E)-N-(3-([3,3'-Bithiophen]-5-ylmethoxy)benzyl)-N-ethyl-6,6-dimethylhept-2-en-4-yn-1-amine hydrochloride | 136719-25-0 | NB-598 is a potent competitive inhibitor of squalene epoxidase (SE). |
| CSN18394 | Otenabant | 686344-29-6 | Otenabant is a selective, potent and competitive CB1 receptor antagonist with Ki of 0.7 nM. |
| CSN18343 | 24, 25-Dihydroxy VD2 | 58050-55-8 | 24, 25-Dihydroxy VD2 is a hydroxylated metabolite of Vitamin D2 and a synthetic analog of Vitamin D. |
| CSN18281 | 1alpha, 24, 25-Trihydroxy VD2 | 457048-34-9 | 1alpha, 24, 25-Trihydroxy VD2 is a vitamin D analog. |
| CSN18265 | Grapiprant | 415903-37-6 | Grapiprant is a selective EP4 receptor antagonist whose physiological ligand is prostaglandin E2 (PGE2). |
| CSN17990 | BMS-191095 | 166095-21-2 | BMS-191095 is an activators of mitochondrial ATP-sensitive potassium (mitoKATP) channels. |
| CSN17526 | EMD638683 R-Form | 1184940-47-3 | EMD638683 R-form is the R-form of EMD638683, which is a highly selective SGK1 inhibitor with IC50 of 3 μM. |
| CSN17485 | (24S)-MC 976 | 112849-14-6 | (24S)-MC 976 is a Vitamin D3 derivative. |
| CSN17674 | GPR40 Activator 1 | 1309435-60-6 | GPR40 activator 1 is a potent GPR40 activator for treatment of type 2 diabetes. |
| CSN18062 | KU14R | 189224-48-4 | KU14R is an I(3)-R antagonist, which selectively blocks the insulin secretory response to imidazolines. |
| CSN17525 | EMD638683 S-Form | 1184940-46-2 | EMD638683 S-form is the S-form of EMD638683. EMD638683 is a highly selective SGK1 inhibitor with IC50 of 3 μM. |
| CSN17358 | DG051 | 929915-58-2 | DG051 is a potent leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis in the enzyme assay with an IC50=47 nM. |
| CSN17532 | DBPR108 | 1186426-66-3 | DBPR108 is a potent, selective, and orally bioavailable dipeptide-derived inhibitor of DPP4 with IC50 of 15 nM showing no inhibition on DDP8 and DPP9. |
| CSN17510 | AZD7687 | 1166827-44-6 | AZD7687 is a potent and selective DGAT1 inhibitor with an IC50 of 80 nM for hDGAT1. |
| CSN17421 | FGH10019 | 1046045-61-7 | FGH10019 is a sterol regulatory element-binding protein (SREBP) inhibitor with IC50 of 1 μM, displaying 5–10 times lower than the IC50 of fatostatin (~10 μM). |
| CSN17974 | 3-O-(2-Aminoethyl)-25-hydroxyvitamin D3 | 163018-26-6 | 3-O-(2-Aminoethyl)-25-hydroxyvitamin D3 is a Vitamin D3 derivative. |
| CSN17617 | Glucocorticoid receptor agonist | 1245526-82-2 | Glucocorticoid receptor agonist is a potent Glucocorticoid receptor agonist. |
| CSN17280 | CPDA | 1415834-63-7 | CPDA is a potent SHIP2 inhibitor that can effectively ameliorate insulin resistance in 3T3-L1 adipocytes. |
| CSN17634 | AMG 837 calcium hydrate | 1259389-38-2 | AMG-837 Calcium is a potent GPR40 agonist (EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents. |
| CSN17433 | GPR120 modulator 2 | 1050506-87-0 | GPR120 modulator 2 is useful for modulating G protein-coupled receptor 120 (GPR120). |
| CSN18038 | HIF-2α-IN-1 | 1799948-06-3 | HIF-2α-IN-1 is a HIF-2α inhibitor has an IC50 of less than 500 nM in HIF-2α scintillation proximity assay. |
| CSN17652 | YLF-466D | 1273323-67-3 | YLF-466D is an allosteric AMPK activator. |
| CSN17432 | GPR120 modulator 1 | 1050506-75-6 | GPR120 modulator 1 is useful for modulating G protein-coupled receptor 120 (GPR120). |
| CSN17484 | (24R)-MC 976 | 112828-09-8 | (24R)-MC 976 is a Vitamin D3 derivative. |
| CSN17364 | Adomeglivant | 1488363-78-5 | Adomeglivant is a potent and selective glucagon receptor antagonist that is used in clinical trial for type 2 diabetes mellitus. |
| CSN17522 | EMD638683 | 1181770-72-8 | EMD638683 is a potent SGK1 inhibitor with an IC50 of 3 μM. |
| CSN17576 | GSK4112 | 1216744-19-2 | GSK4112 is an agonist of Rev-erbα with EC50 of 0.4 μM and it can be designed to mimic the action of heme. |
| CSN17745 | Caficrestat | 1355612-71-3 | Aldose reductase-IN-1 is an inhibitor of aldose reductase with IC50 of 28.9 pM. |
| CSN17924 | NB-598 Maleate | 155294-62-5 | NB-598 is a potent competitive inhibitor of squalene epoxidase (SE). |
| CSN18115 | BTB06584 | 219793-45-0 | BTB06584 is an IF1-dependent selective inhibitor of the mitochondrial F1Fo-ATPase. |
| CSN18191 | RO-28-1675 | 300353-13-3 | Ro 28-1675 is a potent allosteric GK activator with a SC1.5 value of 0.24± 0.0019 μM. |
| CSN18348 | CP-640186 HCl | 591778-70-0 | CP-640186 HCl is a metabolic stability improved ACC inhibitor with IC50 values of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2,respectively. |
| CSN17613 | Etomoxir | 124083-20-1 | Etomoxir is a cell-permeable, irreversible, and stereospecific inhibitor of carnitine palmitoyltransferase (CPT)-1 and DGAT activity in the mitochondria of rat heart H9c2 myoblastic cells at a concentration of 1-80 μM and 40 μM, respectively. |
