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| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN22127 | GLX351322 | 835598-94-2 | GLX351322 is an inhibitor of NADPH oxidase 4, inhibits hydrogen peroxide production from NOX4-overexpressing cells with an IC50 of 5 μ M. |
| CSN21297 | RPR107393 | 197576-78-6 | RPR107393 free base is a selective squalene synthase inhibitor, which inhibits rat liver microsomal squalene synthase with an IC50 of 0.8±0.2 nM. |
| CSN21243 | KI696 | 1799974-70-1 | KI696 is a high affinity probe that disrupts the Keap1/NRF2 interaction. |
| CSN21233 | ND-646 | 1434639-57-2 | ND-646 is an allosteric inhibitor of the ACC enzymes ACC1 and ACC2 that prevents ACC subunit dimerization-to suppress fatty acid synthesis in vitro and in vivo. Chronic ND-646 treatment of xenograft and genetically engineered mouse models of NSCLC inhibited tumor growth. |
| CSN21246 | YM-53601 free base | 182959-28-0 | YM-53601 free base is a squalene synthetase inhibitor which suppresses lipogenic biosynthesis and lipid secretion in rodents. |
| CSN21268 | SB-568849 | 395679-53-5 | SB-568849 is a melanin-concentrating hormone receptor 1 (MCH R1) antagonist with a pKi of 7.7. |
| CSN21267 | YM348 | 372163-84-3 | YM348 is a potent and orally active 5-HT2C receptor agonist, which shows a high affinity for cloned human 5-HT2C receptor (Ki: 0.89 nM). |
| CSN21271 | NGD-4715 | 476322-70-0 | NGD-4715 is a selective and orally active melanin-concentrating hormone receptor 1 (MCHR1) antagonist . |
| CSN21282 | MCHR1 antagonist 2 | 863115-70-2 | MCHr1 antagonist 2 is an antagonist of melanin concentrating hormone receptor 1, with an IC50 of 65 nM; also inhibits hERG, with an IC50 of 4.0 nM in IMR-32 cells. |
| CSN21257 | FR194738 free base | 204067-45-8 | FR194738 free base is a squalene epoxidase inhibitor. FR194738 inhibits squalene epoxidase activity in HepG2 cell homogenates with an IC50 of 9.8 nM. |
| CSN21311 | RP 73163 Racemate | 136609-53-5 | RP 73163 Racemate is the racemate of RP 73163. RP 73163 is a potent ACAT inhibitor, with cholesterol lowering activity. |
| CSN21260 | Vildagliptin dihydrate | 2133364-01-7 | Vildagliptin (LAF237 dihydrate;NVP-LAF 237 dihydrate) is a dipeptidyl peptidase 4 (DPP4) inhibitor that delays the degradation of glucagon-like peptide-1 (GLP-1). |
| CSN22131 | Cort108297 | 1018679-79-2 | Cort108297 is a specific glucocorticoid receptor (GR) antagonist. Cort108297 has a high affinity for GRs with a Ki of 0.45 nM. |
| CSN22344 | AM-1638 | 1142214-62-7 | AM-1638 is a potent and orally bioavailable GPR40/FFA1 full agonist with an EC50 of 0.16 μM. |
| CSN22486 | PF-06471553 | 1808094-07-6 | PF-06471553 is a potent, selective and orally available monoacylglycerol acyltransferase 3 (MGAT3) inhibitor, with an IC50 of 92 nM. |
| CSN22133 | W146 | 909725-61-7 | W146 is a selective antagonist of sphingosine-1-phosphate receptor 1 (S1PR1) with an EC50 value of 398 nM. |
| CSN22389 | E-5324 | 141799-76-0 | E-5324 is potent inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT) with IC50s of 44 to 190 nM. |
| CSN22522 | TR antagonist 1 | 500794-88-7 | TR antagonist 1 is a high-affinity thyroid hormone receptor (TR) antagonist with IC50s of 36 and 22 nM for TRα and TRβ, respectively. |
| CSN22112 | Lodelaben | 111149-90-7 | Lodelaben is a human neutrophil elastase inhibitor with an IC50 and Ki of 0.5 and 1.5 μM, respectively. |
| CSN22439 | JTT 551 | 776309-04-7 | JTT 551 is selective a protein tyrosine phosphatase 1B (PTP1B) inhibitor, with Kis of 0.22 μM and 9.3 μM for PTP1B and TCPTP (T-cell protein tyrosine phosphatase), respectively; JTT 551 can be used in the research of type 2 diabetes mellitus. |
| CSN22510 | Sograzepide | 155488-25-8 | Sograzepide is a gastrin/cholecystokinin 2 receptor (CCK2) antagonist. |
| CSN22122 | Monacolin J | 79952-42-4 | Monacolin J is an inhibitor of cholesterol biosynthesis, and inhibits the activity of HMG-CoA reductase. |
| CSN22411 | GI 181771 | 305366-98-7 | GI 181771 is a cholecystokinin 1 receptor agonist investigated for the treatment of obesity. |
| CSN21375 | TES-1025 | 1883602-21-8 | TES-1025 is a potent and selective human α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD) inhibitor with an IC50 of 13±3 nM. |
| CSN21415 | LMPTP inhibitor 1 HCl | 2310135-38-5 | LMPTP Inhibitor 1 HCl is a selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP), with an IC50 of 0.8 μM LMPTP-A. |
| CSN21353 | Edasalonexent | 1204317-86-1 | Edasalonexent is an orally bioavailable NF-κB inhibitor. |
| CSN21395 | PF-06869206 | 2227425-05-8 | PF-06869206 is an orally bioavailable selective inhibitor of the sodium-phosphate cotransporter NaPi2a (SLC34A1) with an IC50 of 380 nM. |
| CSN21411 | LMPTP inhibitor 1 2HCl | 2310135-46-5 | LMPTP INHIBITOR 1 2HCl is a selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP), with an IC50 of 0.8 μM LMPTP-A. |
| CSN21357 | YK11 | 1370003-76-1 | YK11 is a partial agonist of androgen receptor, with osteogenic activity. |
| CSN22162 | FK-448 Free base | 85858-76-0 | FK-448 Free base is an effective and specific inhibitor of chymotrypsin, with an IC50 of 720 nM. |
| CSN21399 | Saikogenin A | 5092-09-1 | Saikogenin A, extracted from a Chinese herbal plant called Tsai-Fu, is a dipeptidyl peptidase-IV (DPP-IV) inhibitor. |
| CSN22165 | PTP1B-IN-3 | 809272-64-8 | PTP1B-IN-3 is a potent and selective PTP1B inhibitor with IC50s of 120 nM (PTP1B) and 120 nM (TCPTP), respectively. |
| CSN22185 | Elobixibat | 439087-18-0 | Elobixibat is a potent ileal bile acid transporter (IBAT) inhibitor with IC50 values of 0.53 ± 0.17 nM, 0.13 ± 0.03 nM, and 5.8 ± 1.6 nM for human IBAT, mouse IBAT, and canine IBAT. |
| CSN22198 | LY377604 | 204592-94-9 | LY377604 is a human β3-adrenergic receptor agonist with an EC50 of 2.4 nM and also a β1- and β2-adrenergic receptor antagonist. Ly377604 has been used in trials studying the treatment of Obesity. |
| CSN22243 | SNT-207858 | 1104080-42-3 | SNT-207858 is a non-peptide, orally active melanocortin MC-4 receptor antagonist penetrating the blood brain barrier. |
| CSN22244 | XEN723 | 1072803-08-7 | XEN723 is a potent thiazolylimidazolidinone inhibitor of Stearoyl-CoA Desaturase (SCD1) with IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively. |
| CSN22236 | GPR120 Agonist 2 | 1234844-11-1 | GPR120 Agonist 2 is a GPR120 agonist extracted from patent US 20110313003 A1, example 209. |
| CSN22218 | S-8921 | 151165-96-7 | S-8921 is an ileal Na+/bile acid cotransporter (IBAT) inhibitor. |
| CSN22239 | BMS-819881 | 1197420-05-5 | BMS-819881 is a melaninconcentrating hormone receptor 1 (MCHR1) antagonist, which binds rat MCHR1 with a Ki of 7 nM. BMS-819881 also is selective and potent for CYP3A4 activity with an EC50 of 13 μM. |
| CSN22397 | Ertiprotafib | 251303-04-5 | Ertiprotafib is an inhibitor of PTP1B, IkB kinase β (IKK-β), and a dual PPARα and PPARβ agonist, with an IC50 of 1.6 μM for PTP1B, 400 nM for IKK-β), an EC50 of ~1 μM for PPARα/PPARβ. |
| CSN22413 | GLPG0974 | 1391076-61-1 | GLPG0974 is a free fatty acid receptor-2 (FFA2/GPR43) antagonist with an IC50 of 9 nM. |
| CSN22367 | CDK8-IN-3 | 1884500-15-5 | CDK8-IN-3 is an inhibitor of CDK8 extracted from patent WO2016041618A1, compound example 1.7. |
| CSN22395 | EPAC 5376753 | 302826-61-5 | EPAC 5376753 is an allosterically inhibitor of Epac which inhibits Epac1 with an IC50 of 4 µM in Swiss 3T3 cells. |
| CSN22408 | GC 14 | 447415-34-1 | GC 14 is a selective agonist of thyroid hormone β1 activation (TRβ1) with an EC50 of 680 nM. |
| CSN22475 | ORL1 antagonist 1 | 1174985-59-1 | ORL1 antagonist 1 is an opioid receptor-like 1 (ORL1) antagonist with an IC50 of 61 nM. |
| CSN22489 | Mavodelpar free acid | 942594-93-6 | PPARδ agonist is a PPARδ agonist extracted from patent US20180071304, compound example 10. |
| CSN22533 | Velagliflozin | 946525-65-1 | Velagliflozin is an orally available sodium-glucose cotransporter 2 (SGLT2) inhibitor, with anti-diabetic activity. |
| CSN22490 | Pparδ agonist 1 | 1902161-12-9 | Pparδ agonist 1 is a PPAR-δ agonist, with an EC50 of 5.06 nM, used in the research of PPAR-delta related diseases, such as mitochondrial diseases, muscular diseases, vascular diseases, demyelinating diseases and metabolic diseases. |
| CSN22513 | SR 146131 | 221671-61-0 | GI 181771 is a cholecystokinin 1 receptor agonist investigated for the treatment of obesity. |
