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Inflammation/Immunology

货号 产品名 CAS号 信息
CSN17995 Adelmidrol 1675-66-7 Adelmidrol is an ethanolamide derivative of azelaic acid with anti-inflammatory properties partly dependent on PPARγ, it also markedly reduce pro-inflammatory NF-κB pathway.
CSN18163 MCC950 sodium 256373-96-3 MCC950 Sodium is a potent and highly specific small molecule inhibitor of NLRP3 inflammasome with IC50 of 7.5 nM in BMDMs.
CSN18270 PS-1145 431898-65-6 PS-1145 is an IkappaB kinase (IKK) inhibitor with IC50 of 88 nM.
CSN18346 Losmapimod 585543-15-3 Losmapimod is a selective, potent, and orally active p38 MAPK inhibitor with pKi of 8.1 and 7.6 for p38α and p38β, respectively.
CSN18402 Vidofludimus 717824-30-1 Vidofludimus is a potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 134 nM for human DHODH, used as a immunosuppressive drug.
CSN18340 3,3'-((5-Fluoropyrimidine-2,4-diyl)bis(azanediyl))diphenol 575474-82-7 R112, an ATP-competitive inhibitor, can inhibit Syk kinase with Ki of 96 nM.
CSN18307 IRAK-1-4 Inhibitor I 509093-47-4 IRAK-1-4 Inhibitor I is a IRAK-4 inhibitor with IC50 of 200 nM.
CSN18467 cGAMP 849214-04-6 cGAMP, an endogenous second messenger, can induce the formation of cytokines and promote innate immune response. It also acts as an activator of STING with antitumor activity.
CSN18234 NS6180 353262-04-1 NS-6180 is a channel blocker of KCa3.1 (IC50= 9 nM for rat and 14 nM for human). It can prevent T-cell activation and inflammation.
CSN17947 AZD3264 1609281-86-8 AZD3264 is an IkB-kinase IKK2 Inhibitor. IKK2 has been identified as one of the pathways to treat inflammatory conditions such as asthma, chronic pulmonary obstructive disorder (COPD) and rheumatoid arthritis.
CSN18465 Bentamapimod 848344-36-5 AS-602801 is an ATP-competitive JNK inhibitor with IC50 of 80 nM, 90 nM, and 230 nM for JNK1, JNK2, and JNK3, respectively.
CSN18051 AMD 3465 185991-24-6 AMD 3465 is a potent, selective CXCR4 antagonist and exhibits 8-fold higher affinity than AMD 3100 and inhibits SDF-1α-ligand binding (Ki = 41.7 nM).
CSN18219 PCI 29732 330786-25-9 PCI 29732 is a selective and irreversible Btk inhibitor with IC50 of 8.2 nM in a FRET based biochemical enzymology assay.
CSN17882 HG-9-91-01 1456858-58-4 HG-9-91-01 is a potent and highly selective salt-inducible kinase (SIKs) inhibitor with IC50s of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 and SIK3 respectively.
CSN18566 BMS-582949 HCl 912806-16-7 BMS-582949 HCl is a highly selective p38α MAPK inhibitor, inhibits p38α with IC50 of 13 nM.
CSN18528 INCB 3284 887401-92-5 INCB 3284 is a potent, selective and orally bioavailable hCCR2 antagonist with IC50 of 3.7 nM (inhibition of monocyte chemoattractant protein-1 binding to hCCR2).
CSN18411 BAY 61-3606 732983-37-8 BAY 61-3606 is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (Ki= 7.5 nM) with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src.
CSN17816 GSK256066 Trifluoroacetate 1415560-64-3 GSK256066 is a selective PDE4B (equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, > 380,000-fold selectivity versus PDE1/2/3/5/6 and > 2500-fold selectivity against PDE4B versus PDE7.
CSN18104 MCC950 210826-40-7 MCC950 is a potent, selective, small-molecule inhibitor of NLRP3 with IC50 of 7.5 nM in BMDMs.
CSN17833 GSK805 1426802-50-7 RORγt-IN-1 is a potent, orally bioavailable RORγt inhibitor with pIC50 of 8.4 and > 8.2 for RORγ FRET assay and Th17 assay.
CSN18539 Imiquimod maleate 896106-16-4 Imiquimod maleate is an immune response modifier that acts as a toll-like receptor 7 agonist and is commonly used topically to treat warts on the skin of the genital and anal areas.
CSN18171 Reparixin L-lysine salt 266359-93-7 Reparixin L-lysine is an inhibitor of CXCL8 receptor, also inhibit CXCR1 and CXCR2 activation,which has been shown to attenuate inflammatory responses in various injury models.
CSN17912 ML355 1532593-30-8 ML355 is a selective 12-lipoxygenase inhibitor with an IC50 value of 0.34 µM, with much less potency against 15-LO-1, 15-LO-2, and 5-LO (IC50s = 9.7, >100, and >100 µM).
CSN18560 Adapalene sodium salt 911110-93-5 Adapalene sodium is a synthetic retinoid which is a Retinoic acid receptor agonist (RAR).
CSN18456 IFN alpha-IFNAR-IN-1 844882-93-5 IFN alpha-IFNAR-IN-1 is a nonpeptidic, low-molecular-weight inhibitor of the interaction between IFN-α and IFNAR and inhibits MVA-induced IFN-α responses by BM-pDCs (IC50=2-8 μM).
CSN18135 Lansoprazole sodium 226904-00-3 Lansoprazole sodium is a proton pump inhibitor which prevents the stomach from producing acid.
CSN17892 GSK2981278 1474110-21-8 GSK2981278 is a retinoid-related orphan receptor gamma (RORy) modulator.
CSN18487 GSK319347A 862812-98-4 IKK-3 inhibitor is a potent and selective inhibitor of IKK-epsilon kinase with IC50 of 40 nM and is inactive at IKK-α and IKK-β.
CSN18182 BX471 HCl 288262-96-4 BX471 HCl is a potent, selective non-peptide CCR1 antagonist (Ki = 1 nM for human CCR1) and exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4.
CSN18114 BX471 217645-70-0 BX471 is a potent, selective non-peptide CCR1 antagonist (Ki = 1 nM for human CCR1) and exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4.
CSN18352 Bay 65-1942 600734-02-9 Bay 65-1942 is an ATP-competitive inhibitor that selectively targets IKKβ kinase.
CSN18083 Givinostat HCl 199657-29-9 Givinostat HCl is a potent HDAC inhibitor for Maize HD2, HD1-B and HD1-A with IC50 of 10 nM, 7.5 nM and 16 nM, respectively.
CSN18477 NBI-74330 855527-92-3 NBI-74330 is a small molecule antagonist for CXCR3, NBI-74330 demonstrates potent inhibition of [(125)I]CXCL10 and [(125)I]CXCL11 specific binding (K (i) of 1.5 and 3.2 nM, respectively.
CSN18192 RS102895 300815-41-2 RS102895 is a potent and specific CCR2 antagonist with binding IC50 of 360 nM, no significant inhibition on CCR1 (IC50 > 17 μM).
CSN18399 STING agonist-1 702662-50-8 STING agonist-1 is a human-specific STING agonist that elicits antiviral activity against emerging Alphaviruses.
CSN18274 GW627368 439288-66-1 GW627368 is a potent and selective competitive antagonist of prostanoid EP4 receptor (Ki= 100 nM) with additional human TP receptor affinity (Ki= 150 nM).
CSN18329 PNRI-299 550368-41-7 PNRI-299 is a selective AP-1 transcription inhibitor with IC50 of 20 μM without affecting NF-kappaB transcription (up to 200 μM) or thioredoxin (up to 200 μM).
CSN18503 TG 100572 HCl 867331-64-4 TG 100572 HCl is a multi-targeted kinase inhibitor that inhibits select growth factor receptor tyrosine kinases and Src familt kinases with IC50 values of 2/7/2/1/0.5 nM for VEGFR1/VEGFR2/FGFR1/Src/Fyn kianse respectively.
CSN18113 BCX 1470 methanesulfonate 217099-44-0 BCX 1470 methanesulfonate inhibits the esterolytic activity of factor D (IC50=96 nM) and C1s (IC50=1.6 nM), 3.4- and 200-fold better, respectively, than that of trypsin.
CSN18287 AMG 487 473719-41-4 AMG-487 is a small molecule antagonist of the chemokine receptor CXCR3 and inhibits binding of 125I-IP-10 and 125I-ITAC to CXCR3.
CSN18058 PI4KIIIbeta-IN-10 1881233-39-1 PI4KIIIbeta-IN-10 is the most potent PI4KIIIβ inhibitor currently reported, with very minor off-target inhibition of PI4KIIIβ related lipid kinases (IC50 = 3.6 nM).
CSN18112 BCX 1470 217099-43-9 BCX 1470 inhibits the esterolytic activity of factor D (IC50=96 nM) and C1s (IC50=1.6 nM), 3.4- and 200-fold better, respectively, than that of trypsin.
CSN18339 Laropiprant 571170-77-9 Laropiprant is a potent, selective DP1 receptor antagonist with Ki value of 0.57 nM and exhibits > 1,000 fold selectivity over DP2 receptor (Ki=0.75 μM).
CSN18397 Vercirnon 698394-73-9 Vercirnon is a highly potent antagonist of CCR9, which has been implicated in the aetiology of inflammatory bowel diseases such as Crohn's disease.
CSN18176 SD 0006 271576-80-8 SD-06 is a p38 MAP kinase inhibitor and inhibits p38α with an IC50 value of 170 nM and inhibits LPS-stimulated TNF-release in rats(83% inhibition at 1mg/kg, po).
CSN18224 Inulicin 33627-41-7 1-O-Acetylbritannilactone is a sesquiterpene isolated from the medicinal plant Inula britannica with anticancer and anti-inflammation acitvity.
CSN18301 Givinostat 497833-27-9 Givinostat is a potent HDAC inhibitor for Maize HD2, HD1-B and HD1-A with IC50 of 10 nM, 7.5 nM and 16 nM,respectively.
CSN18590 Acitretin sodium 925701-88-8 Acitretin sodium is a second-generation, systemic retinoid and an agonist for retinoic acid receptors that has been used in the treatment of psoriasis.
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