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| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN21369 | Zegocractin | 1713240-67-5 | CM4620 is a CRAC channel inhibitor to treat acute pancreatitis. |
| CSN21221 | AG126 | 118409-62-4 | AG 126 selectively inhibits the phosphorylation of ERK1 and ERK2 at 25-50 μM. |
| CSN21243 | KI696 | 1799974-70-1 | KI696 is a high affinity probe that disrupts the Keap1/NRF2 interaction. |
| CSN21303 | Kynurenic acid sodium | 2439-02-3 | Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also a selective ligand of the GPR35 receptor. |
| CSN21280 | GW-870086 | 827319-43-7 | GW-870086 is a glucocorticoid receptor agonist potentially for the treatment of asthma and atopic dermatitis. |
| CSN21186 | Naproxen etemesil | 385800-16-8 | Naproxen etemesil is a lipophilic, non-acidic, inactive prodrug of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen is a COX-1 and COX-2 inhibitor with IC50s of 2.2 and 1.3 μg/mL, respectively in cell assay. |
| CSN21115 | 3-Deazaadenosine | 6736-58-9 | 3-Deazaadenosine is an inhibitor of S-adenosylhomocysteine hydrolase, with a Ki of 3.9 µM; has anti-inflammatory, anti-proliferative and anti-HIV activity. |
| CSN21322 | Cgs 15435 | 95853-92-2 | CGS 15435, a potent thromboxane (TxA2) synthetase inhibitor with an IC50 of 1 nM, has a selectivity for Tx synthetase 100000-fold greater than that for cyclooxygenase, PGI2 synthetase and lipoxygenase enzymes. |
| CSN21196 | GENZ-882706 | 2070864-35-4 | GENZ-882706 is a potent colony stimulating factor-1 receptor (CSF-1R) inhibitor that intends to treat immune-mediated diseases and neurological diseases. |
| CSN21292 | FR167344 | 215258-13-2 | FR167344 free base is an orally active, nonpeptide bradykinin receptor B2 antagonist. FR167344 free base shows a high affinity binding to the B2 receptor with an IC50value of 65 nM and no binding affinity for the B1 receptor. |
| CSN21197 | ABBV-744 | 2138861-99-9 | ABBV-744 is an inhibitor of BDII-selective BET bromodomain that is being investigated to treat AML and metastic castration-resistant prostate cancer. |
| CSN21343 | Chymase-IN-1 | 862090-74-2 | Chymase-IN-1 is a potent, selective, orally active, nonpeptide inhibitor of human mast cell chymase with an IC50 of 29 nM. |
| CSN21330 | Trifarotene | 895542-09-3 | Trifarotene is a retinoic acid receptor (RAR) agonist with Kdapp of 2, 15 and 500 nM for RARγ, RARβ and RARα, respectively. |
| CSN21139 | DIM-C-pPhOCH3 | 33985-68-1 | DIM-C-pPhOCH3 is a Nur77 agonist. Nerve growth factor-induced Bα (NGFI-Bα, Nur77) is an orphan nuclear receptor. |
| CSN21262 | CU-CPT9b | 2162962-69-6 | CU-CPT9a is a selective Toll-like receptor 8 (TLR8) inhibitor with IC50 of 0.5 nM. It can also suppress TNF-α levels. |
| CSN21128 | IPI-3063 | 1425043-73-7 | IPI-3063 is a potent and selective PI3K p110δ inhibitor with an IC50 of 2.5 ± 1.2 nM. |
| CSN21122 | Desisobutyryl-ciclesonide | 161115-59-9 | Desisobutyryl-ciclesonide is the active metabolite of Ciclesonide. Desisobutyryl-ciclesonide has affinity for the glucocorticoid receptor. |
| CSN21229 | Delgocitinib | 1263774-59-9 | Delgocitinib is a novel and specific JAK inhibitor with IC50s of 2.8, 2.6, 13 and 58 nM for JAK1, JAK2, JAK3 and Tyk2, respectively. |
| CSN21234 | S-methyl-KE-298 | 143584-75-2 | S-methyl-KE-298 is an active metabolite of KE-298. KE-298 inhibits matrix metalloproteinase (MMP-1) production from rheumatoid arthritis (RA) synovial cells. |
| CSN21261 | CU-CPT-9a | 2165340-32-7 | CU-CPT9b is a selective inhibitor of TLR8 with IC50 and Kd of 0.7 nM and 21 nM. |
| CSN21230 | CP-96486 | 139401-45-9 | CP-96486 is a potent and orally active leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor antagonist with Kis of 20 and 24 nM, respectively. |
| CSN21188 | NSC117079 | 500363-63-3 | NSC117079 is a PHLPP inhibitor. |
| CSN21134 | Mebhydrolin | 524-81-2 | Mebhydrolin is a specific histamine H1 receptor antagonist. |
| CSN21223 | AKP-11 | 1220973-37-4 | AKP-11 is a S1P1 agonist with immunomodulatory activities.AKP-11 (1.3mg/kg) attenuates EAE disease. |
| CSN21218 | CY-09 | 1073612-91-5 | CY-09 can inhibit NLRP3 with Kd value of 500 nM through directly bounding to the ATP-binding site of the NLRP3 NACHT domain. |
| CSN21301 | FR183998 | 239440-20-1 | FR183998 free base is a potent Na+/H+-exchange inhibitor, with IC50s of 0.3 nM, 3.1 nM and 6.5 nM by measurement of pHi change in rat lymphocytes, rat and human platelets, respectively. |
| CSN21154 | (S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid | 1025967-78-5 | Lifitegrast is a novel small molecule integrin antagonist which can inhibit an integrin, lymphocyte function-associated antigen 1 (LFA-1), from binding to intercellular adhesion molecule 1 (ICAM-1). |
| CSN21112 | Licogliflozin | 1291094-73-9 | Licogliflozin is a sodium glucose cotransporter (SGLT1 and SGLT2) inhibitor |
| CSN21105 | N-Acetylhistamine | 673-49-4 | N-acetylhistamine is a histamine metabolite. N-acetylhistamine can be used as a potential biomarker of histidine metabolism for anaphylactoid reactions. |
| CSN21315 | Pirolate | 55149-05-8 | Pirolate (CP-32,387) is an antihistamine drug with a tricyclic chemical structure which was patented as an "antiallergen". |
| CSN21394 | RO1138452 | 221529-58-4 | RO1138452 is a selective antagonist of prostacyclin (IP) receptor with pKi of 9.3 ± 0.1 in human platelets. |
| CSN21069 | ABT-702 2HCl | 1188890-28-9 | ABT702 2HCl is a potent non-nucleoside adenosine kinase inhibitor with IC50 value of 1.7 nM, displaying oral activity in animal models of pain and inflammation. |
| CSN20558 | CYM5442 | 1094042-01-9 | CYM-5442 is a highly-selective S1P1 (Spingosine 1-Phosphate Receptor 1) agonist. CYM-5442 reduces the severity of acute GVHD by inhibiting macrophage recruitment. |
| CSN21072 | AB-423 | 1572510-80-5 | AB-423 is Arbutus' first-generation capsid inhibitor, which was generally safe and well tolerated in Phase 1 healthy volunteer studies. |
| CSN20658 | Velsecorat | 1196509-60-0 | AZD7594 is an inhaled selective glucocorticoid receptor (GCCR) modulator for the treatment of mild to moderate asthma and chronic obstructive pulmonary disorder (COPD). |
| CSN20665 | AZD2098 | 566203-88-1 | AZD2098 is a potent CC-chemokine receptor 4 (CCR4) inhibitor, used for asthma research. |
| CSN20549 | S-(+)-Ketoprofen | 22161-81-5 | (S)-Ketoprofen is a potent inhibitor of COX with IC50 of 1.9 and 27 nM for COX1 and 2 respectively. |
| CSN20673 | Leniolisib | 1354690-24-6 | Leniolisib is a potent and selective PI3Kδ inhibitor currently in used for the treatment of immunodeficiency disorders. |
| CSN20632 | Octreotide | 83150-76-9 | Octreotide is an analog of somatostatin that binds to the somatostatin receptor 2/3/5. It can increase Gi activity and reduce the production of intracellular cAMP. |
| CSN20674 | Mavacoxib | 170569-88-7 | Mavacoxib is a veterinary drug used to treat pain and inflammation in dogs with degenerative joint disease. It acts as a COX-2 inhibitor. |
| CSN20611 | BI 665915 | 1360550-04-4 | BI 665915 is an oxadiazole-containing 5-lipoxygenase activating protein (FLAP) inhibitor with binding IC50 < 10 nM and LTB4 synthesis IC50 < 100 nM in human whole blood. |
| CSN20657 | AZD5423 | 1034148-04-3 | AZD5423 is a nonsteroidal glucocorticoid receptor agonist. |
| CSN20666 | AZD-1678 | 942137-41-9 | AZD1678 is a potent CC-chemokine receptor 4 (CCR4) inhibitor, used for asthma research. |
| CSN20566 | PL265 | 1206514-62-6 | PL265 is a preclinical, long-acting dual enkephalinase inhibitor (DENKi), with analgesic potential and has been developed as a therapeutic for control of intractable cancer pain. |
| CSN21103 | MRT67307 2HCl | 1781882-89-0 | MRT67307 HCl is a potent and dual IKKε and TBK1 inhibitor. |
| CSN21410 | H3R antagonist 1 hydrochloride | 2319790-07-1 | H3R-IN-1 HCl is a histamine receptor 3 (H3R) inverse agonist. |
| CSN21351 | MD2-IN-1 | 111797-22-9 | MD2-IN-1 is an inhibitor of Myeloid differentiation protein 2 (MD2) with a KD of 189 μM for the recombinant human MD2 (rhMD2). |
| CSN21399 | Saikogenin A | 5092-09-1 | Saikogenin A, extracted from a Chinese herbal plant called Tsai-Fu, is a dipeptidyl peptidase-IV (DPP-IV) inhibitor. |
| CSN21412 | PMX 205 Trifluoroacetate | N/A | PMX 205 Trifluoroacetate is a potent complement C5a receptor (C5aR; CD88) antagonist. |
