欢迎来到CSNpharm!产品仅用于科研!

400-920-2911 sales@csnpharm.cn

0

GABA Receptor

GABA Receptor

货号 产品名 CAS号 信息
CSN17779 Vigabatrin HCl 1391054-02-6 Vigabatrin HCl is a structural analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) that irreversibly inhibits the catabolism of GABA by GABA transaminase.
CSN19031 U93631 152273-12-6 U93631 is a ligand of GABAA receptor ligand (IC50 = 100 nM) which can induce a rapid decay of GABA-induced chloride currents.
CSN13133 2-Isopropyl-5-methylphenol 89-83-8 Thymol, a natural product isolated and purified from the herbs of Thymus serpyllum L., is a positive allosteric modulator of human GABAA receptors and a homo-oligomeric GABA receptor from Drosophila melanogaster.
CSN21312 SX-3228 156364-04-4 SX-3228 is a selective benzodiazepine1 (BZ1) receptor agonist with an IC50 of 17 nM.
CSN11911 Securinine 5610-40-2 Securinine, a natural product isolated and purified from the leaves and twigs of Securinega suffruticosa with antifungal activity, induces apoptosis in human leukemia HL-60 cells, is a promising monocytic differentiation inducing agent for Acute Myeloid Leukemia (AML).
CSN19979 Sanggenon D 81422-93-7 Sanggenon D, a natural product isolated and purified from the root bark of Morus alba L.
CSN23715 Zuranolone 1632051-40-1 SAGE-217 is an agonist of GABAA receptor with EC50s of 296 nM and 163 nM for α1β2γ2 and α4β3δ respectively.
CSN22497 RO 4938581 883093-10-5 RO 4938581 is a potent and selective GABAA α5 inverse agonist, with a Ki of 4.6 nM for GABAA α5β3γ2a, and shows a lower affinity at α1β3γ2a, α2β3γ2a, α3β3γ2a (Ki, 174, 185, 80 nM, respectively); RO 4938581 is used in the research of cognitive dysfunction.
CSN19798 Ro 48-6791 172407-17-9 Ro 48-6791 is a GABA receptor agonist potentially for the use of anesthesia.
CSN20452 Flumazenil acid 84378-44-9 Ro 15-3890 is an antagonist of benzodiazepine receptor. It is a main metabolite of Ro 15-1788 (flumazenil).
CSN19514 2-(4-Hydroxy-2-oxopyrrolidin-1-yl)acetamide 62613-82-5 Oxiracetam is a derivative of gamma-aminobutyric acid (GABA) and used as a nootropic drug to improve memory and learning.
CSN23642 (R)-2-Amino-4-(methylthio)butanoic acid 348-67-4 MRX-1024 can inhibit the activation of GABAA receptor and exhibit relieving effect on hearing loss. It can used as a chemoprotective agent.
CSN19855 MK-0343 233275-76-8 MK 0343 is a selective partial agonist of GABAAα3, α1, α5 and α2 with Ki values of 0.21 nM-0.40 nM. It displays anxiolytic activity in rodent and primate models.
CSN18575 Lorediplon 917393-39-6 Lorediplon, non-benzodiazepine hypnotic drug, acts as a modulator of GABAA receptor with the effect of promoting sleep.
CSN19849 Loreclezole HCl 2227372-56-5 Loreclezole HCl is a subtype-selective GABAA receptor modulator. Acts as a positive allosteric modulator of β2 or β3-subunit containing receptors.
CSN16300 (S)-4-Aminoisoxazolidin-3-one 339-72-0 L-cycloserine is an inhibitor of serine palmitoyltransferase and block sphingosine biosynthesis. It has antibiotic effective against mycobacterium tuberculosis.
CSN15698 L-838417 286456-42-6 L-838417 is a subtype-selective GABAA receptor partial agonist. L-838417 selectively binds to α1, α2, α3 and α5 subunits (Ki values are 0.79, 0.67, 0.67 and 2.25 nM respectively) but displays no efficacy at α1 (α1-sparing). L-838417 exhibits non-sedative anxiolytic, antinociceptive and anti-inflammatory activity.
CSN17671 L-655708 130477-52-0 L-655708 is a potent α5 subunit-selective GABAA receptor inverse agonist (Ki = 0.45 nM).
CSN12568 (1R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11aS)-3-(1,1-Dimethylethyl)hexahydro-4,7b-dihydroxy-8-methyl-9H-1,7a-(epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione 15291-75-5 Ginkgolide A is an antagonist of g-aminobutyric acid (GABA) with Ki of 14.5 μM and also can activate PAF. It is purified from the leaves of ginkgo biloba tree.
CSN16036 Gaboxadol HCl 85118-33-8 Gaboxadol HCl is a systemically active GABAA receptor agonist and GABAA-ρ receptor antagonist. Displays antinociceptive, anticonvulsant and sedative effects. Hypnotic agent that enhances delta activity within non-REM sleep in rats.
CSN15872 Gabazine 104104-50-9 Gabazine hydrobromide is a drug that acts as an antagonist at GABAA receptors. It is used in scientific research and has no role in medicine, as it would be expected to produce convulsions if used in humans.
CSN12825 2-(1-(Aminomethyl)cyclohexyl)acetic acid 60142-96-3 Gabapentin is an analogue of GABA that used to treat seizures and neuropathic pain.
CSN16669 Gabapentin HCl 60142-95-2 Gabapentin is a GABA analogue, used to treat seizures and neuropathic pain.
CSN16786 Ethyl 8-fluoro-5-methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate 78755-81-4 Flumazenil is a non-selective antagonist of benzodiazepine towards α1, α2, α3 or α5-containing GABAA receptors.
CSN18338 Etifoxine HCl 56776-32-0 Etifoxine HCl is a potentiator of β2 or β3 subunit-containing GABAA receptor that promotes axonal regeneration. It shows anxiolytic activity with no effects.
CSN17006 (2S,2a'E,2a1'S,4'E,5S,6R,6'S,7'S,8'E,11'R,15'S,17a'R,20'R,20a'R)-6-((S)-sec-Butyl)-2a1',20'-dihydroxy-7'-(((2R,4S,5S,6S)-4-methoxy-5-(((2S,4S,5S,6S)-4-methoxy-6-methyl-5-(methylamino)tetrahydro-2H-pyran-2-yl)oxy)-6-methyltetrahydro-2H-pyran-2-yl)oxy)-5,6',8',19'-tetramethyl-2a1',5,6,6',7',10',11',14',15',17a',20',20a'-dodecahydro-2'H,17'H-spiro[pyran-2,13'-[11,15]methano[1,5]dioxacyclooctadecino[9,8,7-cd]benzofuran]-17'-one benzoate 155569-91-8 Emamectin benzoate acts as an activator of chloride channel via binding gamma aminobutyric acid (GABA) receptor and glutamate-gated chloride channels. It can disrupt nerve signals in arthropods.
CSN16005 Cloxacillin sodium 642-78-4 Cloxacillin is a semisynthetic antibiotic that belongs to the group of the isoxazolylpenicillins and is used to treat infections caused by species of staphylococci that produce beta-lactamase due to its inhibitory effects on beta-lactamase binding.
CSN18672 CGS-9896 77779-36-3 CGS-9896 is an anxiolytic drug used in scientific research.
CSN21178 CGP52432 139667-74-6 CGP52432 is an antagonist of GABAB receptor with an IC50 of 85 nM.
CSN22362 Broflanilide 1207727-04-5 Broflanilide is a potential insecticide and metabolized to desmethyl-broflanilide, which is a potent antagonist at the insect resistant-to-dieldrin (RDL) GABA receptor, and inhibits S. litura RDL GABAR, with an IC50 value of 1.3 nM.
CSN17089 Bemegride 64-65-3 Bemegride can stimulate central nervous system and release barbiturate poisoning.
CSN19034 Basmisanil 1159600-41-5 Basmisanil is a selective modulator of GABAAα5 with negative allosteric regulation.
CSN25262 AZD7325 942437-37-8 AZD-7325 is a GABA-Aα2,3 selective receptor modulator.
CSN16275 Imepitoin 188116-07-6 AWD 131-138 is a partial agonist of benzodiazepine receptor with effective anticonvulsant and anxiolytic properties.
CSN23521 6-Methylflavone 29976-75-8 6-Methylflavone is an activator of α1β2γ2L and α1β2 GABAA receptors.
CSN23331 6-Hydroxyflavone 6665-83-4 6-Hydroxyflavone is a naturally occurring flavone, with anti-inflammatory activity. 6-Hydroxyflavone exhibits inhibitory effect towards bovine hemoglobin (BHb) glycation. 6-Hydroxyflavone can activate AKT, ERK 1/2, and JNK signaling pathways to effectively promote osteoblastic differentiation. 6-Hydroxyflavone inhibits the LPS-induced NO production[1] [2].
CSN23335 5-Methoxyflavone 42079-78-7 5-Methoxyflavone, belonged to Flavonoid family, is a DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity. possess central nervous system (CNS) depressant effect mediated through the ionotropic GABAA receptors.
CSN12782 4-Aminobutyric acid 56-12-2 4-Aminobutyric acid exhibits inhibitory activity on central nervous system (CNS). It is a natural neurotransmitter.
CSN23429 H-Glu-OH 56-86-0 (S)-Glutamic acid acts as an excitatory neurotransmitter in the central nervous system.
CSN17026 (R)-4-Amino-3-(4-chlorophenyl)butanoic acid 69308-37-8 (R)-Baclofen is a derivative of gamma-aminobutyric acid with the selective activation of GABAB receptor that is used to treat spasticity.
<< PREV 1 2 3 4 NEXT >>
联系
我们