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FXR
货号 | 产品名 | CAS号 | 信息 |
---|---|---|---|
CSN26168 | Vonafexor | 1192171-69-9 | Vonafexor is a farnesoid X receptor agonist. |
CSN23688 | Tropifexor | 1383816-29-2 | Tropifexor is a potent agonist of FXR with EC50 of 0.26 nM. |
CSN26485 | Tauro-β-muricholic acid sodium | 145022-92-0 | Tauro-β-muricholic Acid sodium (T-βMCA sodium), a endogenous metabolite, is a competitive and reversible farnesoid X receptor (FXR) antagonist, with an IC50 of 40 μM[1][2][3]. |
CSN15954 | T0901317 | 293754-55-9 | T0901317 is a selective agonist for LXR and FXR with EC50 of 50 nM and 5 μM, respectively. |
CSN26448 | PX20606 trans racemate | 1268244-85-4 | PX20606, also known as PX-102, is a FXR agonist. PX20606 induces high-density lipoprotein-mediated transhepatic cholesterol efflux in mice and monkeys and prevent atherosclerosis in cholesteryl ester transfer protein transgenic low-density lipoprotein receptor (-/-) mice. PX20606 demonstrated potent plasma cholesterol-lowering activity that affected all lipoprotein species. |
CSN12883 | (R)-4-((3R,5S,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid | 459789-99-2 | Obeticholic acid is a selective FXR agonist with EC50 of 99 nM and it has anticholestatic activity. |
CSN21073 | Nidufexor | 1773489-72-7 | Nidufexor is a potent farnesoid X receptor (FXR) agonist for the treatment of non-alcoholic steatohepatitis (NASH) and hepatobiliary disorders. |
CSN23776 | LY2562175 | 1103500-20-4 | LY2562175 is a selective and partial FXR agonist with EC50 of 193 nM. |
CSN17377 | INT-767 | 1000403-03-1 | INT-767 is a potent agonist for both FXR (mean EC50, 30 nM by PerkinElmer AlphaScreen assay) and TGR5 (mean EC50, 630 nM by time resolved-fluorescence resonance energy transfer). |
CSN11129 | GW 4064 | 278779-30-9 | GW4064 is a selective, non-steroidal farnesoid X receptor (FXR) agonist (EC50 = 15 nM). |
CSN15997 | Fexaramine | 574013-66-4 | Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity relative to natural compounds. |
CSN28427 | Z-Guggulsterone | 39025-23-5 | (Z)-Guggulsterone is a broad spectrum steroid receptor ligand and an antagonist of FXR with antiseptic, antirheumatic and anti-inflammatory activity in vivo. |
CSN22796 | DY268 | 1609564-75-1 | |
CSN52399 | Isopropyl 3-(3,4-difluorobenzoyl)-1,1-dimethyl-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate | 629664-81-9 |