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Diterpenoids

Diterpenoids

货号 产品名 CAS号 信息
CSN20194 α-Cembrenediol 57605-80-8 VEGFR inhibitor TC1 acts in angiogenesis inhibitory in multiple breast cancer cell lines by significantly reducing the activated VEGFR2 levels.
CSN19412 Triptonide 38647-11-9 Triptonide, a natural product isolated and purified from the herb of Tripterygium wilfordii Hook.f. with antileukemic, antitumor, anti-inflammatory activities, is effective in the treatment of autoimmune diseases. Triptonide can effectively inhibit canonical Wnt/β-catenin signaling by targeting the downstream C-terminal transcription domain of β-catenin or a nuclear component associated with β-catenin.
CSN19415 (5bS,6aS,7aS,8R,8aR,9aS,9bS,10aS,10bS)-8-Hydroxy-8a-isopropyl-10b-methyl-1,5,5b,6,6a,8,8a,9a,9b,10b-decahydrotris(oxireno)[2',3':4b,5;2'',3'':6,7;2''',3''':8a,9]phenanthro[1,2-c]furan-3(2H)-one 38748-32-2 Triptolide, a diterpene triepoxide extracted from the Chinese herb Tripterygium wilfordii, functions as a NF-κB inhibitor with dual actions by disruption of p65/CBP interaction and by reduction of p65 protein.
CSN14774 Taxinine B 18457-44-8 Taxinine B, a natural product isolated and purified from the barks of Taxus chinensis, can inhibit the drug transport by P-glycoprotein in multidrug-resistant cells, and shows stronger inhibitory effects than acetylsalicylic acid (ASA) on platelet aggregation induced by arachidonic acid (AA).
CSN12034 Tanshinone IIB 17397-93-2 Tanshinone IIB (TSB), a natural product isolated and purified from the roots of Salvia miltiorrhiza, can significantly inhibit the DNA laddering, cytotoxicity and apoptosis of rat cortical neurons induced by staurosporine in a concentration-dependent manner. Tanshinone IIB showed inhibitory effect on PL(pro) with IC50 value of 10.7μM and less inhibitory effect on 3CLpro with IC50 value of 24.8μM.
CSN19410 1,6,6-Trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10,11-dione 568-72-9 Tanshinone IIA is a naturally occuring cardioprotective agent which can inhibit NF-κB and AP-1 DNA binding and display antioxidant and anti-inflammatory properties. Tanshinone IIA showed inhibitory effect on PL(pro) with IC50 value of 1.6μM and less inhibitory effect on 3CLpro with IC50 value of 89.1μM.
CSN13570 Steviolbioside 41093-60-1 Steviolbioside, a natural product isolated and purified from the leaves of Stevia rebaudia, is converted into antituberculotic and antibacterial agents. In addition it is used as a natural sweetener.
CSN11904 Sclareolide 564-20-5 Sclareolide is a sesquiterpene lactone natural product derived from various plant sources including Salvia sclarea, Salvia yosgadensis, and cigar tobacco, which may enhance gemcitabine‑induced cell death through mediating the NICD and Gli1 pathways in gemcitabine‑resistant human pancreatic cancer.
CSN11871 Rubusoside 64849-39-4 Rubusoside is a natural sweetener and a solubilizing agent with antiangiogenic and antiallergic properties.
CSN25589 Miltirone 27210-57-7 Rosmariquinone showed inhibitory effect on PL(pro) and 3CLpro with IC50 values of 30μM and 21.1μM, respectively.
CSN15999 (2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl (4R,4aS,6aR,9S,11aR,11bS)-9-(((2S,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3,4-bis(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-4,11b-dimethyl-8-methylenetetradecahydro-6a,9-methanocyclohepta[a]naphthalene-4-carboxylate 58543-16-1 Rebaudioside A, an α-glucosidase inhibitor with IC50 of 35.01 μg/mL. is a steviol glycoside isolated and purified from the leaves of Stevia rebaudiana Bertoni..
CSN11947 Quassin 76-78-8 Quassin, a natural product isolated and purified from the barks of Quassia amara L., inhibits the steroidogenesis in rat Leydig cells in vitro, and has anti-larval activity at a concentration of 6 ppm.
CSN11720 Pimaric acid 127-27-5 Pimaric acid is a natural product isolated and purified from the herbs of Aralia cordata having a potent anti-atherosclerotic activity with inhibitory action on matrix metalloproteinase-9 production and cell migration in TNF-α-induced human aortic smooth muscle cells.
CSN11720 Pimaric acid 127-27-5 Pimaric acid is a natural product isolated and purified from the herbs of Aralia cordata having a potent anti-atherosclerotic activity with inhibitory action on matrix metalloproteinase-9 production and cell migration in TNF-α-induced human aortic smooth muscle cells.
CSN11714 Phytol 150-86-7 Phytol can activite PPARα and attenuate the inflammatory response by inhibiting neutrophil migration and oxidative stress. Phytol is isolated from the leaves of black tea and acts as an aromatic ingredient.
CSN11702 Phorbol 13-acetate 32752-29-7 Phorbol 13-acetate is a reference compound for studying 12-deacylation of phorbol 12-myristate 13-acetate.
CSN10959 Ethyl palmitate 628-97-7 Palmitic acid is a common 16-carbon saturated fat that represents 10-20% of the normal human dietary fat intake.
CSN19419 (1α,6β,7α,14R)-1,5,6,14-Tetrahydroxy-4,4-dimethyl-8-methylenedecahydro-1H-6,11b-(epoxymethano)-6a,9-methanocyclohepta[a]naphthalen-7(8H)-one 28957-04-2 Oridonin is an antitumor agent, a diterpenoid purified from Rabdosia rubescens. Oridonin interacts with the cysteine 279 of NLRP3 NACHT domain through a covalent bond, abolishes NLRP3-NEK7 interaction, and inhibits consequent activation of NLRP3 inflammasome.
CSN14246 Nagilactone C 24338-53-2 Nagilactone C, a natural product isolated and purified from the herbs of Podocarpus neriifolius, possesses potent antiproliferative activity against human fibrosarcoma and murine colon carcinoma tumor cell lines exhibiting ED50 values of 2.3 and 1.2 mg/mL, respectively.
CSN14246 Nagilactone C 24338-53-2 Nagilactone C, a natural product isolated and purified from the herbs of Podocarpus neriifolius, possesses potent antiproliferative activity against human fibrosarcoma and murine colon carcinoma tumor cell lines exhibiting ED50 values of 2.3 and 1.2 mg/mL, respectively.
CSN14255 Lasiokaurin 28957-08-6 Lasiodin, a natural product isolated and purified from the herbs of Isodon japonicus with anti-oxidative action, shows antibacterial activity, esp. against Sarcina lutea and antineoplastic activity against Ehrlich ascites carcinoma.
CSN11232 Isosteviol 27975-19-5 Isosteviol, an antihyperglycemic agent, is a natural product isolated and purified from the herbs of Stevia rebaudiana with anti-hyperglycemic, anti-hypertensive, anti-tumor, anti-inflammatory, and antioxidant properties.
CSN20179 Isopimaric acid 5835-26-7 Isopimaric acid, a natural product isolated and purifed from the herbs of Daemonorops draco Blume, potently opens large conductance Ca-activated K+ channels and also possibly has an antagonistic interaction with reserpine which may render the antibiotics inactive.
CSN19405 5,3'-Diallyl-2,4'-dihydroxybiphenyl 35354-74-6 Honokiol inhibits Akt activation and enhances ERK1/ERK2 phosphorylation, is a hydroxylated biphenyl compound isolated from the Chinese herb Magnolia officinalis with anticancer activities in a variety of cancer cell lines.
CSN11864 (4aR)-7-Isopropyl-1,4a-dimethyl-1,2,3,4,4a,4b,5,6,10,10a-decahydrophenanthrene-1-carboxylic acid 8050-09-7 Gum rosin and wood rosin in Tako-no-Suidashi ointment have an effect on allergic contact dermatitis.
CSN19411 (1S,2R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11R,11aR)- 3-(1,1-Dimethylethyl)hexahydro-2,4,7b,11-tetrahydroxy-8-methyl-9H-1,7a-(Epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3′,2′:3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione 15291-76-6 Ginkgolide C can enhance the cardiac function of rats in the body, is a flavone isolated from Ginkgo biloba leaves.
CSN14586 Galanolactone 115753-79-2 Galanolactone, a natural product isolated and purified from the rhizomes of Zingiber officinale Roscoe with cytotoxic activity, has anti-5-HT effect, a diterpenoid isolated from ginger, is related to antagonism of 5-HT3 receptors, exerts anti-obesity effect through down regulation of adipogenic transcription factors and adipogenic marker genes, and inhibits nitric oxide production with IC(50) values ranging from 5.5 to 28.5 μM.
CSN25431 Estragole 140-67-0 Estragole (4-Allylanisole), a relatively nontoxic volatile terpenoid ether, is a major component of the essential oil of many plants. Estragole dose-dependently blocks nerve excitability. Estragole displays anti-toxoplasma activity.
CSN14581 Eriocalyxin B 84745-95-9 Eriocalyxin B, a natural product isolated and purified from the herbs of Isodon eriocalyx, is a potent NF-kappaB inhibitor, can inhibit the NF-kappaB transcriptional activity but not that of cAMP response element-binding protein.
CSN16500 Dihydrotanshinone I 87205-99-0 Dihydrotanshinone I, a natural product isolated and purified from the roots of Salvia miltiorrhiza Bge., exhibits dose-dependent inhibition towards HLM-catalyzed propofol glucuronidation. Dihydrotanshinone I showed inhibitory effect on PL(pro) with IC50 value of 4.9μM and less inhibitory effect on 3CLpro with IC50 value of 14.4μM.
CSN10311 Deoxyandrographolide 79233-15-1 Deoxyandrographolide is a natural compound extracted from the herbs of Andrographis paniculata (Burm. f.) Nees, promotes glucose uptake through glucose transporter-4 translocation to plasma membrane in L6 myotubes and exerts antihyperglycemic effect in vivo.
CSN10760 (1R,4aS,10aR)-7-Isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxylic acidahydrophenanthrene-1-carboxylic acid 1740-19-8 Dehydroabietic acid, a natural product isolated and purified from the barks of Pinus yunnanensis, displays anti-secretory and anti-pepsin effect in animal models.
CSN10749 Darutigenol 5940-00-1 Darutigenol, a natural product isolated and purified from the herb of Siegesbeckia orientalis., has obvious antithrombotic effect, its mechanism may be related to inhibition of platelet aggregation and adhesion.
CSN19905 Crocin II 55750-84-0 Crocin, a natural product with anti-inflammatory, antihyperlipidemic, antidepressant and anti-apoptotic effects, can ameliorate CCl4-induced liver injury via inhibition of inflammatory cytokines, caspase3 and oxidative stress along with modulation of liver metabolizing enzymes favoring elimination of CCl4 toxic metabolite, it's isolated and purified from the stigma of Crocus sativus L..
CSN16599 Crocin 42553-65-1 Crocin, a natural product isolated and purified from the stigma of Crocus sativus L., can relax smooth muscles with a great potential to be a candidate for the treatment of asthma, protect liver and skeletal muscle tissue against exercise-induced oxidative damage by preventing reactive oxygen species (ROS) production, improve toxic effects of DZN via reducing lipid peroxidation and restoring altered contractile and relaxant responses in rat aorta, protect rat gastric mucosa against ethanol-induced injury via anti-inflammatory, anti-oxidative, anti-apoptotic and mucin-secretagogue mechanisms that are probably mediated by enhanced PGE2 release, significantly inhibit the growth of HO-8910 cells and arrest them in the G0/G1 phase, and also promote ovarian cancer HO-8910 cell apoptosis, most likely by increasing p53 and Fas/APO-1 expression, and then activating the apoptotic pathway regulated by Caspase-3.
CSN20383 Crocetin 27876-94-4 Crocetin, a saffron derivative, is an inhibitor of human lactate dehydrogenase 5 in the antiglycolytic approach against cancer.
CSN26352 Columbin 546-97-4 Columbin is a diterpenoid furanolactone with anti-inflammation activity.
CSN10597 Cephalomannine 71610-00-9 Cephalomannine, a natural product isolated and purified from the barks of Cephalotaxus sinensis (Rehd. et Wils.) Li, is a taxol derivative with antitumor, antiproliferative properties.
CSN20512 Cafestol 469-83-0 Cafestol is a bioactive substance isolated and extracted from coffee with potential medical uses.
CSN14021 Baccatin VI 57672-79-4 Baccatin VI, a taxane derivative isolated and purified from the the heartwood from Taxus mairei, is a neoplasm inhibitor to ovarian and breast cancers.
CSN19460 (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12-(Benzoyloxy)-4,9,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxete-6,12b-diyl diacetate 27548-93-2 Baccatin III is a precursor to the anti-cancer drug paclitaxel, it's a natural product isolated and purified from the barks of Taxus chinensis.
CSN19420 (S,E)-4-Hydroxy-3-(2-((1R,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenedecahydronaphthalen-1-yl)ethylidene)dihydrofuran-2(3H)-one 5508-58-7 Andrographolide is a naturally occuring NF-κB inhibitor.
CSN14049 Ailanthone 981-15-7 Ailanthone, a natural product isolated and purified from the barks of Ailanthus altissima with high toxicity, has significant pre-emergence herbicide activity directly correlated to its concentration.
CSN14257 7-Epi 10-desacetyl paclitaxel 78454-17-8 7-Epi 10-desacetyl paclitaxel is a paclitaxel impurity. The compound, originally isolated from Taxus yunnanensis, has shown potential growth inhibitory activities against human cancer cells.
CSN19770 14-Deoxyandrographolide 4176-97-0 14-Deoxyandrographolide, a natural product isolated and purified from the herbs of Andrographis paniculata (Burm.
CSN14101 14-Deoxy-11,12-didehydroandrographolide 42895-58-9 14-Deoxy-11,12-didehydroandrographolide, herbs of Andrographis paniculata (Burm.
CSN14101 14-Deoxy-11,12-didehydroandrographolide 42895-58-9 14-Deoxy-11,12-didehydroandrographolide, herbs of Andrographis paniculata (Burm.
CSN19449 (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-Acetoxy-4,6,9,11-tetrahydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate 32981-86-5 10-Deacetylbaccatin-III is an intermediate for taxol analog preparations.
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