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| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN13087 | E-4031 | 113559-13-0 | E-4031 is a benzenesulfonamide antiarrhythmic agent which blocks the ATP-sensitive potassium channel. |
| CSN13091 | Fluvastatin Sodium Salt | 93957-55-2 | Fluvastatin Sodium is a synthetic indole-heptanoic-acid-derived inhibitor of hepatic HMG-CoA reductase with IC50 of 8 nM. |
| CSN13104 | Ranolazine | 95635-55-5 | Ranolazine inhibits calcium uptake via the sodium/calcium channel, is used to treat chronic angina. |
| CSN13437 | N-(4-(2-Methyl-1,4,5,6-tetrahydrobenzo[b]imidazo[4,5-d]azepine-6-carbonyl)phenyl)-[1,1'-biphenyl]-2-carboxamide hydrochloride | 168626-94-6 | Conivaptan HCl is an inhibitor of antidiuretic hormone or antagonist of vasopressin receptor. It can inhibit rat liver V1A receptor and kidney V2 receptor with Ki of 0.48 nM and 3.04 nM, respectively. |
| CSN13646 | 2-(2-Chlorophenyl)-4-(3-(dimethylamino)phenyl)-5-methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione | 1218942-37-0 | GKT137831 is a specific dual Nox1/Nox4 inhibitor with Ki of 140±40 nM and 110±30 nM and a potent inhibitor of fibrosis and hepatocyte apoptosis. |
| CSN13827 | (S)-2-((S)-Quinuclidin-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-one hydrochloride | 135729-62-3 | Palonosetron HCl is a carbazole-derived and selective 5-HT3 receptor antagonist. |
| CSN13853 | BRL 54443 | 57477-39-1 | BRL 54443 is a selective agonist for 5-HT1E and 5-HT1F receptor with pEC50 values of 8.5 and 8.6. |
| CSN15688 | N1-(5-Chloropyridin-2-yl)-N2-((1S,2R,4S)-4-(dimethylcarbamoyl)-2-(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamido)cyclohexyl)oxalamide 4-methylbenzenesulfonate hydrate | 1229194-11-9 | Edoxaban tosylate is a selective factor Xa inhibitor with Ki of 0.561 nM, > 10 000-fold selectivity over thrombin and FIXa, and is also an orally bioavailable anticoagulant drug. |
| CSN15708 | Methyl (4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)(methyl)carbamate | 625115-55-1 | Riociguat acts as stimulator of soluble guanylate cyclase (sGC) that is used to treat ipulmonary hypertension. |
| CSN15715 | Evacetrapib | 1186486-62-3 | Evacetrapib is a potent and selective inhibitor of CETP with IC50 of 5.5 nM. |
| CSN15727 | (S)-Methyl 2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetate | 113665-84-2 | Clopidogrel is a P2Y12 receptor blocker (IC50 = 100 nM). |
| CSN15854 | Clopidogrel hydrogen sulfate | 120202-66-6 | Clopidogrel Hydrogen Sulfate is the functional enantiomer of clopidogrel and a potent P2Y12 receptor antagonist. |
| CSN15960 | Regadenoson | 313348-27-5 | Regadenoson is a selective adenosine A2A receptor agonist with Ki value of 1.1nM for pig striatum A2A receptor, used as a novel pharmacologic stress agent under clinical development for myocardial perfusion imaging. |
| CSN15703 | Temocapril HCl | 110221-44-8 | Temocapril HCl is a long-acting and prodrug-type ACE inhibitor,not approved for use in US, but approved in Japan and South Korea. |
| CSN13066 | Ramipril | 87333-19-5 | Ramipril is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 5 nM. |
| CSN13567 | Fimasartan | 247257-48-3 | Fimasartan is an improved non-peptide angiotensin II receptor blocker used for the treatment of hypertension and heart failure, which enables higher potency and longer duration than losartan. |
| CSN13575 | Amlodipine Besylate | 111470-99-6 | Amlodipine Besylate is a long-acting calcium channel blocker used to lower blood pressure and prevent chest pain. |
| CSN15798 | RPR-260243 | 668463-35-2 | RPR-260243 is an activator of HERG which modifies HERG currents inhibited by dofetilide (IC50 = 58 nM) and shows little effect on HERG current amplitude and no significant effects on steady-state activation parameters or on channel inactivation processes. |
| CSN13054 | Benazepril HCl | 86541-74-4 | Benazepril HCl is an ACE inhibitor, primarily used in treatment of hypertension. Benazepril HCl is the HCl form of Benazepril. |
| CSN13719 | Ticlopidine HCl | 53885-35-1 | Ticlopidine HCl is an adenosine diphosphate (ADP) receptor inhibitor that against platelet aggregation with IC50 of ~2 μM. |
| CSN15706 | Darapladib | 356057-34-6 | Darapladib is a reversible lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor with IC50 of 0.25 nM. |
| CSN13736 | N-(5-(4-Bromophenyl)-6-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-4-pyrimidinyl)-N'-propylsulfamide | 441798-33-0 | Macitentan is an antagonist of endothelin receptor A (ETA) with IC50 of 0.5 nM. It is developed for treatment of pulmonary arterial hypertension (PAH). |
| CSN14141 | Arjunolic acid | 465-00-9 | Arjunolic acid, a natural peroxisome proliferator-activated receptor alpha agonist isolated and purified from the fruits of Terminalia chebula Retz., can protect against cisplatin-induced testicular injury by attenuating oxidative stress parameters along with downregulation of iNOS, TNF-α, and p38-MAPK testicular expressions. |
| CSN14079 | Ophiopogonin D | 945619-74-9 | Ophiopogonin D, a natural product isolated and purified from Radix Ophiopogon japonicus, protects the heart against doxorubicin-induced autophagic injury by reduction of both ROS generation and the disruption of the mitochondrial membrane damage. |
| CSN13464 | Guanfacine HCl | 29110-48-3 | Guanfacine HCl is a centrally acting antihypertensive with α2-adrenoceptor agonist with Kd value of 31 nM for α2A-adrenoceptor while displaying 60-fold selectivity over α2B-adrenoceptors, causing a decrease in heart rate and peripheral vascular resistance. |
| CSN15735 | N-(4-(2-(Methyl(2-(4-(methylsulfonamido)phenoxy)ethyl)amino)ethyl)phenyl)methanesulfonamide | 115256-11-6 | Dofetilide is a potassium channel blocker that acts as a class III antiarrhythmic drug. It is used for the treatment of atrial fibrillation and flutter. |
| CSN13178 | N6-(4-Hydroxybenzyl)adenosine | 110505-75-4 | N6-(4-Hydroxybenzyl)adenosine is an inhibitor of platelet aggregation induced in vitro by collagen and their activity range was demonstrated (IC50: 6.77-141 μM). |
| CSN13483 | Sacubitril | 149709-62-6 | AHU-377 and valsartan can compose LCZ696 in a 1:1 molar ratio. It also works as an inhibitor of neprilysin with IC50 value of 5 nM. |
| CSN16028 | Perindopril | 82834-16-0 | Perindopril is a long-acting ACE inhibitor of which is used to treat high blood pressure, heart failure or stable coronary artery disease. |
| CSN13637 | Clopidogrel thiolactone | 1147350-75-1 | Clopidogrel thiolactone is a P2Y12 receptor inhibitor, is a potent antiplatelet agent. |
| CSN13633 | Azilsartan medoxomil monopotassium | 863031-24-7 | Azilsartan medoxomil is an orally administered angiotensin II receptor type 1 antagonist with IC50 of 0.62 nM, which used in the treatment of adults with essential hypertension. |
| CSN13691 | Edoxaban tosylate | 480449-71-6 | Edoxaban is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention. |
| CSN15972 | GW3965 | 405911-09-3 | GW3965 is a potent, selective LXR agonist for hLXRα and hLXRβ with EC50 of 190 and 30 nM, respectively. |
| CSN13782 | Vorapaxar | 618385-01-6 | Vorapaxar is a thrombin receptor (protease-activated receptor, PAR-1) antagonist. |
| CSN13167 | VTP-27999 | 942142-51-0 | VTP-27999 is an alkyl amine Renin inhibitor, and is useful for hypertension and end-organ diseases. |
| CSN13629 | Prazosin HCl | 19237-84-4 | Prazosin HCl is a selective α-1-adrenergic receptor antagonist used to treat hypertension, anxiety, and posttraumatic stress disorder (PTSD). |
| CSN13720 | NS309 | 18711-16-5 | NS-309 is a positive modulator of small- and intermediate- conductance Ca2+-activated K+ channels (KCa2 and KCa3.1 channels). It increases Ca2+ sensitivity and displays no activity at BK channels. |
| CSN13812 | Avanafil | 330784-47-9 | Avanafil is a potent and highly selective phosphodiesterase-5 (PDE-5) inhibitor with IC50 of 5.2 nM for erectile dysfunction, exhibiting lower selectivity against PDE1, PDE6, and PDE11. |
| CSN13055 | Benazepril | 86541-75-5 | Benazepril is an ACE inhibitor, primarily used in treatment of hypertension. |
| CSN13903 | Rostafuroxin | 156722-18-8 | Rostafuroxin is an antihypertensive compound and a Na,K-ATPase antognist which displaces [3H]ouabain from the dogkidney Na+,K+-ATPase with IC50 of 1.5 nM. |
| CSN13683 | Lomitapide | 182431-12-5 | Lomitapide is an inhibitor of microsomal triglyceride-transfer protein (MTP) wtih in vitro IC50 of 8 nM. |
| CSN13485 | 2-Aminoethan-1-ol hemi((Z)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylate) | 496775-62-3 | Eltrombopag olamine is an orally active thrombopoietin-receptor (c-mpl) agonist that stimulates thrombopoiesis. |
| CSN15799 | S0859 | 1019331-10-2 | S0859, an N-cyanosulphonamide compound, reversibly inhibit NBC-mediated pH (i) recovery (K (i)=1.7 mM, full inhibition at approximately 30 mM). |
| CSN13519 | Corynoxeine | 630-94-4 | Corynoxeine is a potent ERK1/2 inhibitor of key PDGF-BB-induced VSMC proliferation, and is a useful and prospective compound in the prevention and treatment for vascular diseases. |
| CSN15931 | Nortadalafil | 171596-36-4 | Nortadalafil is demethyl tadalafil, which is a PDE5 inhibitor, currently marketed in pill form for treating erectile dysfunction (ED) and pulmonary arterial hypertension. |
| CSN15973 | NP118809 | 41332-24-5 | NP-118809 is a potent N-type calcium channel blocker with IC50 of 0.11 μM, showing good selectivity over L-type calcium channels. |
| CSN16004 | NF449 octasodium | 627034-85-9 | NF449 is a potent purinergic receptor antagonist that displays high selectivity for P2X1 (IC50 values are 0.28, 0.69, 120, 1820, 47000 and > 300000 nM for rP2X1, rP2X1+5, rP2X2+3, rP2X3, rP2X2 and P2X4 receptors respectively). Provides antithrombotic protection in vivo. Also acts as a Gsα-selective antagonist. |
| CSN16010 | TG100-115 | 677297-51-7 | TG100-115 is a PI3Kγ/δ inhibitor with IC50 of 83 nM/235 nM, with little effect on PI3Kα/β. |
