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| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN17464 | ITD-1 | 1099644-42-4 | ITD-1 is a selective TGFβ pathway inhibitor with IC50 of 0.85 μM and can act as an inducer of TGFβ type II receptor degradation. |
| CSN17898 | Azimilide 2HCl | 149888-94-8 | Azimilide 2HCl, a class III antiarrhythmic compound, blocks the Kv7.1 and Kv11.1 patassium channels. It also inhibits Na+/Ca2+ exchanger in vitro. |
| CSN18214 | GlyH-101 | 328541-79-3 | GlyH-101, a glycinyl hydrazone compound, is a reversible and voltage-dependent CFTR chloride channel blocker with Ki of 4.3 μM. |
| CSN18407 | rel-(2R,3R)-3-(Isopropylamino)-1-((7-methyl-2,3-dihydro-1H-inden-4-yl)oxy)butan-2-ol hydrochloride | 72795-01-8 | ICI 118551 HCl is a selective and inverse β2 adrenergic receptor antagonist with Ki values of 1.2, 120 and 257nM for β2, β1 and β3 receptors, respectively. |
| CSN18470 | GSK269962A | 850664-21-0 | GSK269962A is a potent ROCK inhibitor (IC50 values are 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively), and displays greater than 30-fold selectivity for ROCK against a panel of serine/threonine kinases. |
| CSN18500 | PRX-08066 | 866206-54-4 | PRX-08066 is a novel 5-HT2B receptor antagonist with IC50 of 3.4 nM. |
| CSN18583 | SAR407899 | 923359-38-0 | SAR407899 is a potent, ATP-competitive ROCK inhibitor woth Ki value of 36 nM/41 nM for human ROCK/Rat ROCK respectively. |
| CSN18204 | ICA-121431 | 313254-51-2 | ICA-121431 is a nanomolar potent small molecule Nav1.7 channel inhibitor with IC50 of 19 nM for rat Nav1.7, but no inhibition on human, monkey and dog Nav1.7. |
| CSN18644 | (S)-(-)-Bay-K-8644 | 98625-26-4 | Bay-K-8644 (S)-(-)- is an agonist of L-type Ca2+ channel. Bay-K-8644 (S)-(-)- activates Ba2+ currents (IBa) (EC50=32 nM). |
| CSN18372 | Urapidil HCl | 64887-14-5 | Urapidil HCl is a multiple-target antihypertensive drug as an α1-adrenoceptor antagonist, an α2-adrenoceptor agonist and an 5-HT1A receptor agonist. |
| CSN17902 | Ro 46-2005 | 150725-87-4 | Ro 46-2005 is an antagonist of endothelin receptor. |
| CSN18549 | JI-101 | 900573-88-8 | JI-101 is an oral multi-kinase inhibitor that targets vascular endothelial growth factor receptor type 2 (VEGFR-2), platelet derived growth factor receptor β (PDGFR-β), and ephrin type-B receptor 4 (EphB4). |
| CSN18442 | Nafamostat | 81525-10-2 | Nafamostat is a broad spectrum serine protease inhibitor, kallikrein inhibitor, and inhibits blood coagulation. It is also a possible complement inhibitor. |
| CSN18529 | LUF6000 | 890087-21-5 | LUF6000 is an allosteric modulator of the human A3 adenosine receptor (AR). |
| CSN17471 | Efonidipine HCl | 111011-53-1 | Efonidipine HCl is a dual T-type and L-type calcium channel blocker (CCB). |
| CSN18627 | Sodium formononetin-3'-sulfonate | 949021-68-5 | Sodium formononetin-3'-sulfonate is a water-soluble derivate of formononetin. |
| CSN18010 | BQ-788 | 173326-37-9 | BQ-788 is a potent and selective endothelin receptor subtype B (ETB) antagonist with IC50 of 1.2 nM (inhibits 125I-labeled endothelin 1 (ET-1) binding to ETB receptors on human Girardi heart cells). |
| CSN18256 | Prasugrel Maleic acid | 389574-20-3 | Prasugrel maleic acid is a platelet inhibitor with IC50 value of 1.8 μM. |
| CSN17680 | BIX 02565 | 1311367-27-7 | BIX-02565 is a ribosomal S6 kinase 2 (RSK2) inhibitor with an IC50 of 1.1 nM. |
| CSN18087 | N-(2,2,2-Trifluoroethyl)-9-(4-(4-(4'-(trifluoromethyl)-[1,1'-biphenyl]-2-ylcarboxamido)piperidin-1-yl)butyl)-9H-fluorene-9-carboxamide methanesulfonate | 202914-84-9 | Lomitapide Mesylate is a MTTP inhibitor with IC50 of 8 nM, used as a complement to a low-fat diet and other lipid-lowering treatments in patients with homozygous familial hypercholesterolemia. |
| CSN18342 | HOKU-81 | 58020-43-2 | HOKU-81, a bronchodilator, is one of the metabolites of tulobuterol. |
| CSN17643 | VTP-27999 HCl | 1264191-73-2 | VTP-27999 HCl is an alkyl amine Renin inhibitor and is useful for Hypertension and End-Organ Diseases. |
| CSN18499 | (R)-5-Chloro-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)thiophene-2-carboxamide | 865479-71-6 | 5-R-Rivaroxaban is an (R) enantiomer of rivaroxaban, an oral, direct Factor Xa (FXa) inhibitor in late-stage development for the prevention and treatment of thromboembolic disorders. |
| CSN18545 | TP-10 | 898563-00-3 | TP-10 is a PDE10A inhibitor with IC50 of 0.8 nM. |
| CSN18082 | Y-33075 | 199433-58-4 | Y-33075 is potent and selective p160 ROCK inhibitor with an Ki value of 0.14 μM, > 200 fold selectivity for p160ROCK than PKC, cAMP-dependent protein kianse and Mypsin light-chain kinase. |
| CSN17685 | Miransertib | 1313881-70-7 | ARQ-092 is an orally bioavailable, selective, and potent allosteric Akt inhibitor with IC50 of 2.7 nM, 14 nM and 8.1 nM for Akt1, Akt2, Akt3, respectively. |
| CSN18070 | Otamixaban | 193153-04-7 | Otamixaban is a potent (Ki = 0.5 nM), selective, rapid acting, competitive and reversible fXa inhibitor that effectively inhibits both free and prothrombinase-bound fXa. |
| CSN18052 | Cilobradine HCl | 186097-54-1 | Cilobradine HCl is an HCN Channel blocker and an open channel blocker of neuronal Ih and related cardiac If channels. |
| CSN18437 | Nafamostat HCl | 80251-32-7 | Nafamostat HCl is a broad spectrum serine protease inhibitor, kallikrein inhibitor, and inhibits blood coagulation. It is also a possible complement inhibitor. |
| CSN18578 | AZD1283 | 919351-41-0 | AZD1283 is a potent antagonist of the P2Y12 receptor with EC50 of 3.0 ug/kg/min, TI > 10 and with binding IC50 of 11 nM. |
| CSN18599 | TY-52156 | 934369-14-9 | TY-52156 is a potent S1P3 receptor antagonist in a competitive manner, and the Ki value is estimated to be 110 nM for S1P3 receptor. |
| CSN18472 | MK-0354 | 851776-28-8 | MK-0354 is a partial agonist of GPR109a receptor, for hGPR109a/ mGPR109a with EC50 of 1.65/1.08 μM, showed no activation of GPR109b. |
| CSN18217 | Cinaciguat | 329773-35-5 | Cinaciguat is the first of a class of soluble guanylate cyclase (sGC) activators in clinical development for acute decompensated heart failure. |
| CSN17466 | Aprocitentan | 1103522-45-7 | ACT-132577 is the major and pharmacologically active metabolite of macitentan), which is dual ETA/ETB endothelin (ET) receptor antagonist designed for tissue targeting. |
| CSN17989 | Terutroban | 165538-40-9 | Terutroban is a thromboxane/prostaglandin endoperoxide receptor antagonist. |
| CSN18626 | ML365 | 947914-18-3 | ML365 is a selective small molecule inhibitor of TASK1 (KCNK3) with IC50 of 4 nM (thallium influx fluorescent assay) and 16 nM (automated electrophysiology assay). |
| CSN18333 | Macitentan (n-butyl analogue) | 556797-16-1 | Macitentan n-butyl analogue is a n-butyl analogue of Macitentan (ACT064992), which is an orally active, non-peptide dual endothelin ETA and ETB receptor antagonist for the potential treatment of idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH). |
| CSN17431 | Cardiogenol C HCl | 1049741-55-0 | Cardiogenol C HCl is a cell-permeable pyrimidine compound which potently induces the differentiation of ESCs into cardiomyocytes (EC50= 100 nM). |
| CSN18248 | Istaroxime HCl | 374559-48-5 | Istaroxime HCl is a positive inotropic agent that mediates its action through inhibition of sodium/potassium adenosine triphosphatase (Na+/K+ ATPase). Istaroxime HCl is a potent inhibitor of Na+,K+-ATPase with IC50 of 0.11 μM. |
| CSN17790 | ML277 | 1401242-74-7 | ML277 is a potent and selective K(v)7.1 (KCNQ1) potassium channel activator with EC50 of 270 nM. |
| CSN18427 | Pimobendan HCl | 77469-98-8 | Pimobendan HCl is a selective inhibitor of PDE3 with IC50 of 0.32 μM. |
| CSN18526 | Methyldopa HCl | 884-39-9 | L-(-)-α-Methyldopa HCl is an alpha-adrenergic agonist (selective for α2-adrenergic receptors) psychoactive drug used as a sympatholytic or antihypertensive. |
| CSN18663 | (3-((4-((2-Amino-3-chloropyridin-4-yl)oxy)-3-fluorophenyl)carbamoyl)-5-(4-fluorophenyl)-4-oxopyridin-1(4H)-yl)methyl dihydrogen phosphate | 1174161-69-3 | BMS-798433 shows greater than 50% TGI for at least one tumor doubling time with no toxicity observed during 14 days in GTL-16 human gastric tumor xenografts model. |
| CSN18579 | Zatebradine HCl | 91940-87-3 | Zatebradine HCl is a potent HCN channels antagonist, which decreased the heartbeat in a reversible manner with 92% inhibition of the hHCN1-mediated current at 10 μM. |
| CSN18645 | (R)-(+)-Bay-K-8644 | 98791-67-4 | Bay-K-8644 (R)-(+)- is a calcium channel inhibitor. Bay-K-8644 (R)-(+)- inhibits Ba2+ currents (IBa) (IC50=975 nM). |
