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Cardiovascular Disease

货号 产品名 CAS号 信息
CSN21304 SL910102 144756-71-8 SL910102 is a nonpeptide angiotensin AT1 receptor antagonist.
CSN21291 ML171 6631-94-3 ML171 is a novel and selective NOX1 inhibitor with IC50 value of 0.25 μM for blocking NOX1-dependent ROS generation in a HEK293-NOX1 recombinant cell system.
CSN21155 L-NMMA Acetate 53308-83-1 L-NMMA acetate is a nitric oxide synthase inhibitor of all NOS isoforms including NOS1, NOS2, and NOS3. The Ki values for nNOS (rat), eNOS (human), and iNOS (mouse) are approximately 0.18, 0.4, and 6 µM, respectively.
CSN21293 Caldaret 133804-44-1 Caldaret is an intracellular Ca2+ handling modulator that acts through reverse mode Na+/Ca2+ exchanger inhibition.
CSN21258 Tecadenoson 204512-90-3 Tecadenoson is a selective A1 adenosine receptor agonist.
CSN21296 AGN 192836 171102-29-7 AGN 192836 is a potent and selective α2 adrenergic agonist with EC50s of 8.7, 41 and 6.6 nM for α2A, α2B and α2C receptor, respectively.
CSN21163 Canrenone 976-71-6 Canrenone can specifically antagonize aldosterone at the mineralocorticoid receptor.
CSN21247 (±)-WS75624B 188048-45-5 (±)-WS75624B is an endothelin converting enzyme (ECE) inhibitor with an IC50 of 0.03 μg/mL.
CSN21177 Mitochonic Acid 5 1354707-41-7 Mitochonic acid 5 binds mitochondria and ameliorates renal tubular and cardiac myocyte damage. Mitochonic acid 5 modulates mitochondrial ATP synthesis.
CSN21324 Naminidil 220641-11-2 Naminidil is a cyanoguanidine KATP opener.
CSN21301 FR183998 239440-20-1 FR183998 free base is a potent Na+/H+-exchange inhibitor, with IC50s of 0.3 nM, 3.1 nM and 6.5 nM by measurement of pHi change in rat lymphocytes, rat and human platelets, respectively.
CSN21162 BPTU 870544-59-5 BPTU allosteric antagonist of P2Y1 wtih IC50 of 0.06-0.3 μM with antithrombotic effect and reduces platelet aggregation.
CSN21294 BM121307 137213-91-3 BM121307 is a guanylate cyclase activator that was in phase I development for the treatment of ischaemic heart disorders. The research has been discontinued.
CSN22524 Trombodipine 113658-85-8 Trombodipine is an antithrombotic agent.
CSN22330 RP 54275 81364-78-5 2-Octadecyl-1H-indole-5-carboxylic acid is a novel hypocholesterolaemic drug.
CSN22500 RP-64477 135239-65-5 RP-64477 is a potent inhibitor of the cholesterol esterifying enzyme Acyl-coenzyme A:cholesterol O-acyltransferase (ACAT).
CSN22508 SM 16 614749-78-9 SM 16 is an an ATP-competitive ALK5/ALK4 inhibitor with IC50 value between 160 and 620 nM for inhibition of TGF-β1-induced Smad2/3 phosphorylation in cell study.
CSN22138 J-104132 198279-45-7 J-104132 is a potent, orally active ETA/ETB receptor antagonist, with Kis of 0.034 nM and 0.104 nM for cloned human ETA and ETB receptors expressed in CHO cells.
CSN22112 Declaben 111149-90-7 Lodelaben is a human neutrophil elastase inhibitor with an IC50 and Ki of 0.5 and 1.5 μM, respectively.
CSN22136 Edg-2 Receptor Inhibitor 1 1195941-38-8 Edg-2 receptor inhibitor 1 is an Edg-2 receptor inhibitor extracted from patent WO2009135590A1, Compound Example 14, has an IC50 of <0.1 μM.
CSN22113 Ifetroban 143443-90-7 Ifetroban is a long-acting thromboxane A2 receptor antagonist, with antiplatelet activity.
CSN22149 Prolylleucine 61596-47-2 Prolylleucine is a dipeptide containing branched-chain amino acids.
CSN22140 Y-9738 59399-41-6 Y-9738 is a hypolipidemic agent.
CSN22110 Bepridil HCl 68099-86-5 Bepridil HCl is a calcium channel blocker, with antianginal activity.
CSN22111 Carbacyclin 69552-46-1 Carbacyclin is a PGI2 analogue, acts as a prostacyclin (PGI2) receptor agonist and vasodilator, and potently inhibits platelet aggregation.
CSN22530 Ubrogepant 1374248-77-7 Ubrogepant is an oral calcitonin gene-related peptide receptor (CGRP) antagonist in development for acute treatment of migraine.
CSN22159 ICI 153110 87164-90-7 ICI 153110 is an orally active phosphodiesterase inhibitor with both vasodilating and inotropic properties which is designed for the treatment of congestive cardiac failure.
CSN21356 S107 HCl 1357476-46-0 S107 HCl is a RyR-selective 1,4-benzothiazepine derivative that stabilizes RyR2 channels by enhancing the binding affinity of calstabin2 to mutant and/or PKA-phosphorylated channels.
CSN22181 OM-189 55381-18-5 OM-189 is a selective synthetic thrombin inhibitor.
CSN22174 CE-245677 717899-97-3 CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50s of 4.7 and 1 nM.
CSN21359 SQ-31765 138383-07-0 SQ-31765 is a benzazepine calcium channel blocker.
CSN22154 F 16915 92510-91-3 F 16915 is a docosahexaenoic acid derivative which can prevent heart failure-induced atrial fibrillation.
CSN21398 PKG Drug G1 374703-78-3 PKG Drug G1 targets C42 of PKG Iα. PKG drug G1 can couple to vasodilation and blood pressure lowering by a C42 PKG Iα-independent mechanism.
CSN22178 PRX933 HCl 639029-42-8 PRX933 HCl is a 5-HT2c receptor agonist.
CSN21408 KAI-9803 949100-39-4 KAI-9803 is a potent and selective δ protein kinase C (δ PKC) inhibitor.
CSN22168 FKK 78299-79-3 FKK is an indazole derivative and also a novel bronchodilator.
CSN22205 TAK-024 186971-69-7 TAK-024 is a platelet inhibitor with IC50s of 31, 79 and 51 nM in human, monkey and guinea pig, respectively.
CSN22246 TA-7552 104756-72-1 TA-7552 is a potent cholesterol-lowering agent.
CSN22235 Almokalant 123955-10-2 Almokalant is a class III antiarrhythmic drug, acts as a potassium channel blocker, and inhibits a specific component (Ikr) of the time-dependent delayed rectifier K+ current.
CSN22338 AE-3763 291778-77-3 AE-3763 is a peptide-based human neutrophil elastase inhibitor with an IC50 of 29 nM.
CSN22373 CGRP Antagonist 1 1123757-49-2 CGRP antagonist 1 is a highly potent CGRP receptor antagonist with a Ki and IC50 of 35 and 57 nM, respectively.
CSN22398 ETA Antagonist 1 161801-60-1 ETA antagonist 1 is a ETA selective antagonist with an IC50 of 0.08 μM.
CSN22431 Ingliforib 186392-65-4 Ingliforib is a glycogen phosphorylase inhibitor, with IC50s of 52, 352 and 150 nM for liver, muscle and brain glycogen phosphorylase, and has cardioprotective activity.
CSN22395 EPAC 5376753 302826-61-5 EPAC 5376753 is an allosterically inhibitor of Epac which inhibits Epac1 with an IC50 of 4 µM in Swiss 3T3 cells.
CSN22463 Megakaryocytes/platelets Inducing Agent 1429321-13-0 Megakaryocytes/platelets inducing agent is an inducing agent for megakaryocytes and/or platelets from pluripotent stem cells, the inducing agent being useful in treating diseases involving thrombopenia.
CSN22511 Solenopsin 137038-57-4 Solenopsin is an ATP-competitive AKT inhibitor with IC50 value of 10 μM .
CSN22490 Pparδ Agonist 1 1902161-12-9 Pparδ agonist 1 is a PPAR-δ agonist, with an EC50 of 5.06 nM, used in the research of PPAR-delta related diseases, such as mitochondrial diseases, muscular diseases, vascular diseases, demyelinating diseases and metabolic diseases.
CSN22444 L-765314 189349-50-6 L-765314 is a potent and selective α1b adrenergic receptor antagonist with Kis of 5.4±0.6 nM and 2.0±0.66 nM for rat and human α1b adrenergic receptor, respectively.
CSN22536 ZD-0892 171964-73-1 ZD-0892 is a selective and potent inhibitor of a neutrophil elastase with Kis of 6.7 and 200 nM for human neutrophil elastase and porcine pancreatic elastase, respectively.
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