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| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN20347 | SMI-16a | 587852-28-6 | SMI-16a, the PIM1/2 Kinase inhibitor VI, controls the biological activity of PIM1/2. This small molecular inhibitor is primarily used for Phosphorylation & Dephosphorylation applications |
| CSN20354 | SC-560 | 188817-13-2 | SC-560 is a highly selective cyclooxygenase-1 (COX-1) inhibitor (IC50 values are 0.009 and 6.3 μM for COX-1 and COX-2 respectively). It inhibits COX-1-derived platelet thromboxane B2, gastric PGE2 and dermal PDE2 production and significantly reduces ovarian surface epithelial tumor growth in vivo. |
| CSN20383 | Crocetin | 27876-94-4 | Crocetin, a saffron derivative, is an inhibitor of human lactate dehydrogenase 5 in the antiglycolytic approach against cancer. |
| CSN20418 | GW4869 | 6823-69-4 | GW4869 2HCl is a cell permeable, selective and non-competitve inhibitor of N-SMase (neutral sphingomyelinase), which is important in the metabolism of sphingomyelin producing ceramide and phosphocholine and in cell signaling and regulation. GW4869 is an exosome inhibitor. |
| CSN20445 | TPI-1 | 79756-69-7 | TPI-1 is a protein tyrosine phosphatase inhibitor with IC50 of 40nM increased SHP1 phospho-substrates (pLck-pY394, pZap70 and pSlp76) in Jurkat T cells but had little effects on pERK1/2 or pLck-pY505 regulated by phosphatases SHP2 or CD45, respectively. TPI-1 was shown to be more effective than sodium stibogluconate in SHP1 inhibition, immune cell activation and anti-tumor action. |
| CSN20446 | T56-LIMKi | 924473-59-6 | T 5601640 is a selective LIMK2 inhibitor which can inhibit cofilin phosphorylation in cells that overexpress LIMK2 but not LIMK1. |
| CSN20450 | Indisulam | 165668-41-7 | Indisulam is a carbonic anhydrase inhbitor and a synthetic sulfonamide targeting the G1 phase of the cell cycle. |
| CSN20451 | 3-((1H-Imidazol-5-yl)methylene)-5-methoxyindolin-2-one | 666837-93-0 | SU9516 (mixture) is a 3-substituted indolinone compound and a competitive inhibitor of CDC2 CDK2 and CDK4 that displaying anti-proliferative and proapoptotic properties in tumor cells. It is the mixture form of SU9516. |
| CSN20454 | 10074-G5 | 413611-93-5 | 10074-G5 is a c-Myc Max interaction inhibitor. |
| CSN20455 | (Rac)-SAR131675 | 1092539-44-0 | SAR131675 is a selective inhibitor of VEGFR-3 (IC50 = 20 nM) with antitumoral and antimetastatic activities. |
| CSN20459 | BTB-1 | 86030-08-2 | BTB1 an ATP-competitive and selective inhibitor of the mitotic motor protein Kif18A with IC50 value of 1.7 μM. |
| CSN20474 | Methyl 3-(2-(4-(adamantan-1-yl)phenoxy)acetamido)-4-hydroxybenzoate | 934593-90-5 | LW6 is a HIF-1 inhibitor with an IC50 of 4.4 μM. |
| CSN20477 | 2-Methyl-7-(phenyl(phenylamino)methyl)quinolin-8-ol | 6964-62-1 | NSC 66811 is a potent MDM2 inhibitor with Ki value of 120 nM which can disrupt MDM2-p53 interaction and activate p53 function. |
| CSN20482 | CGP-53716 | 152459-94-4 | CGP-53716 is a selective tyrosine kinase inhibitor of PDGFR. |
| CSN20494 | Thiomyristoyl | 1429749-41-6 | Thiomyristoyl is an inhibitor of Sirt2 and Sirt1 with IC50 of 28 nM, 98 μM. |
| CSN20497 | ISCK03 | 945526-43-2 | ISCK03 is a cell-permeable c-Kit inhibitor with IC50 < < 2.5 μM in cell-free kinase assays and blocks SCF-induced c-kit and Erk phosphorylation (1 μM causes > 90% inhibition) without any effect on HGF-induced Erk phosphorylation in 501mel melanoma cells, it's a phenyl-imidazolosulfonamide compound. |
| CSN20502 | MSX-127 | 6616-56-4 | MSX-127 is a potent phosphatase inhibitor. |
| CSN20515 | inS3-54A18 | 328998-53-4 | inS3-54-A18 is an inhibitor of STAT3 that suppresses tumor growth, metastasis and the expression of STAT3 target genes. |
| CSN20516 | SU5408 | 15966-93-5 | SU5408 is a VEGFR2 kinase inhibitor with IC50 of 70 nM in murine. |
| CSN20517 | LDC4297 | 1453834-21-3 | LDC4297 is a potent CDK7 selective inhibitor with IC50 of 0.13 ± 0.06 nM. |
| CSN20532 | MK571 | 115104-28-4 | MK-571 sodium is a selective, orally active CysLT1 receptor antagonist, which blocks the binding of LTD4, but not LTC4, to human and guinea pig lung membranes with Ki values of 0.22 nM and 2.1 nM, respectively. |
| CSN20533 | (Z)-SU5614 | 1055412-47-9 | SU-5614 is an inhibitor of FLT3. In Ba/F3 and AML cell lines expressing a constitutively activated FLT3, SU-5614 exhibits significant cell growth inhibition and cell cycle arrest. |
| CSN20483 | Plicamycin | 18378-89-7 | Mithramycin A is an anticancer antibiotic that selectively binds to G-C-rich DNA in the presence of Mg2+ or Zn2+, inhibiting RNA and DNA polymerase action, and inhibits c-myc expression and induces myeloid differentiation of HL-60 promyelocytic leukemia cells. |
| CSN20461 | WT-161 | 1206731-57-8 | WT161 selectively inhibits HDAC6 that exhibits effective anti-tumor activities in multiple myeloma. |
| CSN20525 | NI-57 | 1883548-89-7 | NI-57 is an orally active pan-BRPF chemical probe of the bromodomain (BRD) of the BRPFs. |
| CSN20550 | SU4312 | 5812-07-7 | SU 4312 is a potent and selective inhibitor of VEGFR and PDGFR tyrosine kinases (IC50 values are 0.8 and 19.4 μM respectively), which is selective over EGFR and c-Src tyrosine kinases. |
| CSN20470 | STX-0119 | 851095-32-4 | STX-0119 is a potent STAT3 inhibitor. STX-0119 is an efficient therapeutic to overcome TMZ resistance in recurrent GBM tumors, and could be the next promising compound leading to survival prolongation. |
| CSN20439 | PRMT5-IN-30 | 330951-01-4 | PRMT5 inhibitor C17 is a potent, selective, and cell active protein arginine methyltransferase 5 (PRMT5) inhibitor (IC50 = 0.33 μM) exhibited a broad selectivity against a panel of other methyltransferases. |
| CSN20471 | Arcyriaflavin A | 118458-54-1 | Arcyriaflavin A is a potent inhibitor of cdk4/cyclin D1 (IC50 = 59 nM) and CaM kinase II (IC50 = 25 nM) but displays selectivity over several other kinases in vitro (IC50 values for inhibition of PKA and PKC are > 2 and > 100 μM respectively). It can also inhibit human cytomegalovirus (HCMV) replication in vitro (IC50 = 200 nM). |
| CSN20440 | BAY-707 | 2109805-96-9 | BAY-707 is a potent and cellularly active inhibitor devalidate MTH1 as broad-spectrum cancer target. |
| CSN20465 | Nevanimibe HCl | 133825-81-7 | ATR-101 HCl is a selective inhibitor of acyl coenzyme A:cholesterol acyltransferase (ACAT1), it is in clinical development for the treatment of adrenocortical carcinoma (ACC). |
| CSN20434 | PROTAC TBK1 degrader-2 | 2052306-13-3 | PROTAC TBK1 C3i is a potent hit (TBK1 DC50 = 12 nM, Dmax = 96%) with excellent selectivity against a related kinase IKKε, which was further used as a chemical tool to assess TBK1 as a target in mutant K-Ras cancer cells. |
| CSN20361 | MRS 1477 | 212200-21-0 | MRS1477 is a positive allosteric modulator of TRPV1 channels targeting breast cancer cells. |
| CSN20380 | Nimbolide | 25990-37-8 | Nimbolide is a terpenoid lactone isolated and purified from A. indica (Neem tree) that demonstrates antimalarial and anticancer effects in experimental models. |
| CSN20348 | SAR125844 | 1116743-46-4 | SAR125844 is a potent and highly selective c-Met inhibitor with potential antineoplastic activity. |
| CSN20396 | JAK1-IN-4 | 2091134-35-7 | AZD4205 is a potent ATP-competitive inhibitor that inhibits JAK1 with a Ki of 2.8 nM and exhibits excellent selectivity compared with other JAK family kinases and across the kinome. |
| CSN20388 | PRN1371 | 1802929-43-6 | PRN1371 is an irreversible covalent FGFR inhibitor used for the treatment of solid tumor. |
| CSN20410 | Hedgehog Inhibitor C15h | 1616368-12-7 | Hedgehog inhibitor C15h displays a potent hedgehog-inhibitory activity with an IC50 of 0.050 nM. |
| CSN20491 | Echinomycin | 512-64-1 | Echinomycin is a highly potent and selective HIF-1α inhibitor (IC50 = 29.4 pM) which selectively inhibits HIF-1 binding to the VEGF promoter without affecting the binding of AP-1 or NF-κB. |
| CSN20378 | Dfp-11207 | 1296177-16-6 | DFP-11207 is a n orally available thymidylate synthase (TS) inhibitor with potential antineoplastic activity. |
| CSN20402 | TACE Inhibitor C3 | 1219812-22-2 | TACE inhibitor C3 is a prodrug of hydantoin based TNF-α converting enzyme (TACE) inhibitor. |
| CSN20507 | GNF-8625 | 1196546-33-4 | GNE-8525 is a potent and selective pan-TRK inhibitor, demonstrated potent antiproliferation activity with IC50 = 0.003 μM. In a tumor xenograft model derived from the KM12 cell line, GNE-8525 demonstrated in vivo antitumor efficacy when administered at ascending doses twice daily (bid) for 14 days in rats. |
| CSN20508 | TrkA Inhibitor C6t | 1377503-70-2 | TrkA inhibitor C6t is a potent and selective TrkA inhibitor (IC50=1.67 nM) showing activity in cellular proliferation and apoptosis assays and exhibiting antiangiogenic activity. |
| CSN20337 | FEN1-IN-4 | 1995893-58-7 | FEN1 inhibitor C2 is an inhibitor of flap endonuclease 1 (FEN1) which is required for proficient DNA replication and the repair of DNA damage. |
| CSN20521 | Pichromene | 883046-50-2 | S14161 is a small molecule inhibitor of cyclins D1-D3 expression that inhibits phosphoinositide 3-kinase activity and arrests cells at the G0/G1 phase in a dose-dependent manner (concentrations tested from 5-10 μM). |
| CSN20338 | FEN1-IN-3 | 2109805-87-8 | FEN1 inhibitor C3 is an inhibitor of flap endonuclease 1 (FEN1) which is required for proficient DNA replication and the repair of DNA damage. |
| CSN20519 | CP-31398 2HCl | 1217195-61-3 | CP-31398 2HCl is a p53 stabilizing agent which stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53. |
