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Antibacterial
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN20572 | Zidebactam | 1436861-97-0 | Zidebactam is an inhibitor of PBP2 showing potent "β-lactam enhancer" activity against Pseudomonas aeruginosa, including multidrug-resistant metallo-β-lactamase-producing high-risk clones. |
| CSN19718 | Virstatin | 88909-96-0 | Virstatin is an anti-cholera substance. |
| CSN20568 | Vaborbactam | 1360457-46-0 | Vaborbactam is a cyclic boronic acid pharmacophore β-lactamase inhibitor showing broad-spectrum inhibitor, notably restoring the activity of carbapenems against KPC-producing strains. |
| CSN20307 | TXA707 | 1609670-89-4 | TXA707, an inhibitor of essential bacterial protein FtsZ, is associated with potent activity against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) that are resistant to current standard-of-care antibiotics. |
| CSN20308 | TXA6101 | 1459695-66-9 | TXA6101, an inhibitor of essential bacterial protein FtsZ, retains activity against MRSA isolates that express either G196S or G193D mutant FtsZ, which confer resistance to TXA707. |
| CSN19823 | Trovafloxacin | 147059-72-1 | Trovafloxacin is a broad spectrum antibiotic that inhibits the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. |
| CSN18893 | Tosufloxacin tosylate hydrate | 1400591-39-0 | Tosufloxacin Tosylate Hydrate works as an antimicrobial agent, an antiinfective agent, a DNA synthesis inhibitor, a hepatotoxic agent and a topoisomerase IV inhibitor. |
| CSN18720 | Tolclofos-methyl | 57018-04-9 | Tolclofos-methyl is a broad-spectrum aromatic hydrocarbon fungicide that is used as a see treatment for protection against soil-borne and seed borne fungal pathogens that caused seed decay and seedling blights. |
| CSN19292 | (4S,4aS,5aR,12aS)-9-(2-(tert-Butylamino)acetamido)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide | 220620-09-7 | Tigecycline is a glycylcycline-class antibiotic used for a number of bacterial infections. |
| CSN20564 | Temocillin | 66148-78-5 | Temocillin, a 6-α-methoxy derivative of ticarcillin, is a β-lactamase-resistant penicillin used primarily for the treatment of multiple drug-resistant, Gram-negative bacteria. |
| CSN20468 | TAM-16 | 2030241-59-7 | TAM16 is a benzofuran class inhibitor of polyketide synthase 13 (Pks13) with highly potent in vitro bactericidal activity against drug-susceptible and drug-resistant clinical isolates of M. tuberculosis. |
| CSN19306 | Sulfamerazine sodium salt | 127-58-2 | Sulfamerazine sodium is a sulfonamide antibacterial. |
| CSN19305 | 4-Amino-N-(4-methylpyrimidin-2-yl)benzenesulfonamide | 127-79-7 | Sulfamerazine is a sulfanilamide antibacterial agent working by inhibiting bacterial synthesis of dihydrofolic acid through competing with PABA (para-aminobenzoic acid) for binding to dihydropteroate synthetase (dihydrofolate synthetase). |
| CSN19831 | Streptomycin | 57-92-1 | Streptomycin is an antibiotic (antimycobacterial) drug, the first of a class of drugs called aminoglycosides to be discovered, and it was the first effective treatment for tuberculosis. |
| CSN20580 | Sulfaclozine sodium | 23307-72-4 | Sodium Sulfaclozine is a competitive antagonist of PABA (para-aminobenzoic acid). |
| CSN19490 | Sodium 4-Aminosalicylate Dihydrate | 6018-19-5 | Sodium 4-Aminosalicylate Dihydrate is competitive pteridine synthetase inhibitor with antituberculocis activity. |
| CSN20653 | Sarecycline HCl | 1035979-44-2 | Sarecycline HCl is a tetracycline-derived narrow-spectrum antibiotic for the treatment of inflammatory lesions of non-nodular moderate to severe acne vulgaris. |
| CSN18765 | Procodazole | 23249-97-0 | Procodazole is a non-specific active immunoprotective agent against viral and bacterial infections, used as a potentiator. |
| CSN20364 | PEP Inhibitor C1 | 2109805-71-0 | PEP inhibitor C1 inhibits a wide variety of the peptidase domains of bacterial ComA-like ABC transporters, including those of Streptococcus commensal species, some of which may function in the maintenance of the commensal flora. Thus, it should be noted that this inhibitor might disturb the beneficial effect of the nasopharyngeal commensals when used as a drug. |
| CSN20664 | Nemonoxacin malate | 951163-60-3 | Nemonoxacin malate is a non-fluorinated quinolone antibiotic approved for treatment of community-acquired pneumonia, and exhibits potent activity against Gram-positive bacteria, including MRSA and fluoroquinolone-resistant MRSA, Gram-negative and atypical pathogens. |
| CSN19278 | Mrl-436 | 2095432-38-3 | MRL-436 is a small molecule which binds to RNAP through a binding site that differs from the rifampin binding site, inhibits rifampin-resistant RNAP derivatives, and exhibits antibacterial activity against rifampin-resistant strains. |
| CSN19786 | Mesuaxanthone A | 3561-81-7 | Mesuaxanthone A has an anti-Mycobacterium tuberculosis activity. |
| CSN19416 | Mafenide | 138-39-6 | Mafenide is a sulfonamide-type medication. |
| CSN20333 | M4284 | 1373346-85-0 | M4284, a high-affinity inhibitory mannoside targeting FimH, reduces intestinal colonization of genetically diverse UPEC isolates, while simultaneously treating UTI, without notably disrupting the structural configuration of the gut microbiota. |
| CSN20538 | Voxvoganan | 1166254-80-3 | LTX-109 is a synthetic antimicrobial peptide, showing activity against methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, daptomycin-nonsusceptible, and linezolid-nonsusceptible Staphylococcus aureus. |
| CSN20229 | LpxC Inhibitor C1(-) | 1219365-61-3 | LpxC inhibitor C1(-) is an inhibitor of Pseudomonas aeruginosa deacetylase LpxC whose cytotoxicity against mammalian cell lines was reduced, solubility and plasma-protein binding (PPB) was improved while retaining potent anti-pseudomonal activity in vitro and in vivo. |
| CSN20620 | Lefamulin | 1061337-51-6 | Lefamulin is a pleuromutilin antibacterial compound. |
| CSN20414 | Delpazolid | 1219707-39-7 | LCB01-0371 shows good activity against Gram-positive pathogens. |
| CSN20280 | LBM-415 | 478913-91-6 | LBM-415 is a peptide deformylase (PDF) inhibitor. |
| CSN20662 | Ganfeborole | 2131798-12-2 | GSK3036656 shows potent inhibition of Mtb LeuRS (IC50 = 0.20 μM) and in vitro antitubercular activity (Mtb H37Rv MIC = 0.08 μM). Additionally, it is highly selective for the Mtb LeuRS enzyme with IC50 of > 300 μM and 132 μM for human mitochondrial LeuRS and human cytoplasmic LeuRS, respectively. |
| CSN20305 | Lanopepden | 1152107-25-9 | GSK-1322322 is a potent and selective peptide deformylase inhibitor with good in vitro activity against bacteria associated with community-acquired pneumonia and skin infections. GSK1322322 has bactericidal activity against S. pneumoniae, H. influenzae, S. pyogenes, and S. aureus, demonstrating a ≥ 3-log (10) decrease in the number of CFU/mL at 4× MIC within 24 h in 29 of the 33 strains tested. |
| CSN20390 | ETX2514 | 1467157-21-6 | ETX2514 is a broad-spectrum β-lactamase inhibitor for the treatment of drug-resistant Gram-negative bacteria including Acinetobacter baumannii. |
| CSN19477 | D-(+)-Cycloserine | 68-41-7 | D-Cycloserine is a broad-spectrum antibiotic against Gram-negative bacteria working by inhibiting cell wall biosynthesis (D-Ala peptide bond formation). It is also a partial agonist at the glycine modulatory site of NMDA glutamatergic receptors. |
| CSN20260 | (R)-5-((3-((6,8-Dibromochroman-4-yl)amino)propyl)amino)thieno[3,2-b]pyridin-7(4H)-one | 1013915-71-3 | CRS-3123 is a methionyl-tRNA synthetase inhibitor potentially for the treatment of enteric infections. |
| CSN20472 | Cotrimoxazole (Trimethoprim/sulfamethoxazole 1:5) | 8064-90-2 | Co-trimoxazole is an antibiotic used to treat a variety of bacterial infections including urinary tract infections, MRSA skin infections, travelers' diarrhea, respiratory tract infections, and cholera. |
| CSN20575 | Cefteram | 82547-58-8 | Cefteram is a third-generation cephalosporin antibiotic. |
| CSN20406 | Brd4592 | 2119598-24-0 | BRD4592, a synthetic azetidine derivative, kills Mycobacterium tuberculosis (Mtb) through allosteric inhibition of tryptophan synthase (TrpAB), a previously untargeted, highly allosterically regulated enzyme. |
| CSN18884 | BM212 | 146204-42-4 | BM212 is a pyrrole-derived antimycobacterial with strong inhibitory activity against bothMycobacterium tuberculosis and some nontuberculosis mycobacteria. |
| CSN19273 | Avibactam sodium hydrate | 2938989-90-1 | Avibactam sodium is a covalent, reversible β-lactamase inhibitor, inhibits β-lactamase TEM-1 and CTX-M-15 with IC50 of 8 nM and 5 nM, respectively. |
| CSN18883 | Apramycin Sulfate | 65710-07-8 | Apramycin sulfate(1:x) is an aminoglycoside antibiotic mproduced by a strain of Streptomyces tenebrarius, used in veterinary practice. |
| CSN18890 | Apramycin | 37321-09-8 | Apramycin is an aminoglycoside antibiotic used in veterinary medicine. |
| CSN18885 | Antibiotic-5d | 251349-54-9 | Antibiotic-5d is a synthesis and antimicrobial compound. |
| CSN19267 | (2S,5R,6R)-6-[(R)-2-Amino-2-phenylacetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid | 69-53-4 | Ampicillin is a broad-spectrum beta-lactam antibiotic against a variety of Gram-positive and Gram-negative bacteria. |
