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货号 产品名称 CAS号 简介
CSN25551 ((2R,3S,4R,5R)-3,4-Dihydroxy-5-(4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl isobutyrate  2635324-86-4 EIDD-2801 is an orally bioavailable prodrug of EIDD-1931, which has a broad-spectrum antiviral activity against 39 multiple coronaviruses, including S
CSN25566 (2S,4R)-1-(2-(3-Acetyl-5-(2-methylpyrimidin-5-yl)-1H-indazol-1-yl)acetyl)-N-(6-bromopyridin-2-yl)-4-fluoropyrrolidine-2-carboxamide  1903768-17-1 Danicopan is selective and orally active small-molecule factor D inhibitor, shows high binding affinity to human Factor D with Kd value of 0.54 nM. It
CSN25632 3-([(3,4-DIchlorophenyl)amino]carbonyl)bicyclo[2.2.1]hept-5-ene-2-carboxylic acid  199735-88-1 CADD522 is a small molecule that inhibits the DNA binding of RUNX2. It negatively regulated transcription of RUNX2 target genes such as matrix metallo
CSN25635 3,4-Dichlorobenzo[b]thiophene-2-carbohydrazide  350997-39-6 O8 OGG1 Inhibitor is an inhibitor of OGG1 with IC50 value of 0.35μM in fluorescence-based OGG1 assays. It can inhibit Schiff base formation during OGG
CSN25655 Ethyl 5-(7-(chlorodifluoromethyl)-5-(furan-2-yl)pyrazolo[1,5-a]pyrimidine-2-carboxamido)-1-phenyl-1H-pyrazole-4-carboxylate  944547-46-0 Mycro3 is a small-molecule inhibitor of Myc-Max dimerization. The average residual tumor of Pdx1-cre/KRAS* mice after Mycro3 treatment (100mg/kg, oral
CSN25872 N-((5-Chloropyridin-2-yl)carbamothioyl)-3-nitro-4-(piperidin-1-yl)benzamide  838810-96-1 MAC-545496 is a nanomolar inhibitor of GraR. It reverses β-lactam resistance in the community-acquired MRSA USA300 strain.
CSN25874 6-Methyl-3-(2-(1-(pyridin-2-yl)ethylidene)hydrazinyl)-5H-[1,2,4]triazino[5,6-b]indole  327031-55-0 VLX600 is a novel iron-chelating inhibitor of oxidative phosphorylation, potentiated the effect of radiation in tumor spheroids in a synergistic manne
CSN26106 N-(3-Bromo-2-fluorophenyl)-7,8-dihydro-[1,4]dioxino[2,3-g]quinazolin-4-amine  2305154-31-6 JCN037 is a potent EGFR inhibitor with IC50 values of 2.49 nM, 3.95 nM and 4.48 nM for EGFR, p-wtEGFR and pEGFRvⅢ, respectively. It displayed potent a
CSN26157 (R)-3-((Tetrahydrofuran-2-yl)methyl)-2-thioxo-1,2,3,9-tetrahydro-6H-purin-6-one  618913-30-7 AZD5904 is a potent and irreversible MPO inhibitor with IC50 value of 140nM. Continuous subcutaneous AZD5904 infusion during the 2 week selectively bl
CSN26164 (3E,5E)-3,5-Bis(4-nitrobenzylidene)piperidin-4-one  919091-63-7 RA-9 is a cell permeable and potent inhibitor of the ubiquitin-proteasome system (UPS) that targets deubiquitinating enzymes (DUB) without affecting 2
CSN27187 4-(((5'-chloro-2'-(((1R,4r)-4-(((R)-1-methoxypropan-2-yl)amino)cyclohexyl)amino)-[2,4'-bipyridin]-6-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile  1263373-43-8 NVP-2 is a potent and selective ATP-competitive CDK9 inhibitor with IC50 value of 0.5nM.
CSN27185 5-Benzyl-2-hydroxy-3-nitrobenzaldehyde  328565-16-8 Col003 is a cell penetrant, selective and potent inhibitor of the interaction of Hsp47 with collagen. Col003 is the cleavage product of AK778.It compe
CSN27196 (2-Amino-4-(trifluoromethoxy)phenyl)(4-(7-(4-methylpiperazin-1-yl)pyrido[3,2-d]pyrimidin-4-yl)piperidin-1-yl)methanone  2307249-33-6 BAY-885 is a highly potent and selective ERK5 inhibitor with IC50 value of 35nM.
CSN27227 (E)-N-(4-((E)-3,5-Dimethoxystyryl)phenyl)-3-(3,4,5-trimethoxyphenyl)acrylamide  2059952-75-7 STAT3-IN-1 (compound 7d) is an excellent, selective and orally active STAT3 inhibitor, with IC50 values of 1.82 μM and 2.14 μM in HT29 and MDA-MB 231
CSN27236 (4S,7S,10S,13S)-13-(2-Chloroacetyl)-4-(4-hydroxybenzyl)-7-isopropyl-10-methyl-2,5,8,11-tetraoxo-3,6,9,12-tetraazapentadecan-15-oic acid  178603-78-6 Ac-YVAD-CMK is a tetrapeptide ICE inhibitor.
CSN27229 (S)-5-((1-(3-Oxo-3-(4-(5-(trifluoromethyl)pyrimidin-2-yl)piperazin-1-yl)propoxy)propan-2-yl)amino)-4-(trifluoromethyl)pyridazin-3(2H)-one  2381037-82-5 RBN-2397 is a potent, accross species and orally active NAD+ competitive inhibitor of PARP7 (IC50<3 nM). RBN-2397 selectively binds to PARP7 (Kd=0.001
CSN27231 4-(3-Benzyl-4-{[5-(2-fluorophenyl)furan-2-yl]methylidene}-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid  916232-21-8 GS143 is a selective IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 sup­presses NF-κB activati
CSN27232 (R)-4-(2-((5-Fluoro-6-methoxypyridin-3-yl)amino)-5-(1-(4-(methylsulfonyl)piperazin-1-yl)ethyl)pyridin-3-yl)-6-methyl-1,3,5-triazin-2-amine  1253573-53-3 AMG 511 is a potent and orally available pan inhibitor of class I PI3Ks, with Kis of 4 nM, 6 nM, 2 nM and 1 nM for PI3Kα, β, δ and γ, respectively. AM
CSN27247 N'-((6-Bromoimidazo[1,2-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide  372196-67-3 PIK-75 is a selective p110α inhibitor with IC50 of 5.8 nM with 200-fold more potently than p110β, and also potently inhibits DNA-PK with IC50 of 2 nM.
CSN27252 3,4-Dihydroxy-N'-(2-hydroxybenzylidene)benzohydrazide  304481-60-5 KM91104 is a specific v-ATPase inhibitor. It specifically targets the interaction between v-ATPase subunit a3 and subunit B2.
CSN27270 Lithium 2-(6-(1H-imidazol-1-yl)pyridazine-3-carboxamido)-4,5-difluorobenzoate  2375421-09-1 SR-717 is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. Ant
CSN27278 2-((1-(3-Fluorophenyl)cyclohexyl)amino)-N-hydroxypyrimidine-5-carboxamide  1375466-18-4 ACY-775 is a potent and selective inhibitor of the of histone deacetylase 6 (HDAC6) with an IC50 of 7.5 nM.
CSN27283 6-(1-Acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)nicotinamide  1655504-04-3 Orelabrutinib is an irreversible inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity.
CSN27291 5-((2,5-Dichloropyrimidin-4-yl)amino)-3-(3-hydroxy-3-methylbutyl)-1-methyl-1H-benzo[d]imidazol-2(3H)-one  2253878-09-8 BCL6-IN-5 is a potent BCL6 inhibitor exacted from patent WO2018215801A1 with pIC50 of 5.82.
CSN27285 4-((4-Benzyl-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)pyrido[3',2':4,5]thieno[3,2-d]pyrimidine  1841460-82-9 TH1020 is Toll-like receptor (TLR) 5/Flagellin complex antagonist with IC50 of 0.85 μM. TH1020 competes with flagellin for TLR5 binding to inhibit the
CSN27287 (S)-N2-(Benzo[d]oxazol-6-yl)-N4-(1-cyclohexylethyl)-N6-ethyl-N6-(2-(ethylamino)ethyl)-1,3,5-triazine-2,4,6-triamine  1456891-34-1 LS-102 is a selective inhibitor of E3 ubiquitin ligase synoviolin (Syvn1). LS-102 inhibits the autoubiquitination of synoviolin with an IC50 of 35 μM.
CSN27297 (2S)-6-Amino-2-[(2S)-6-amino-2-[(2S)-6-amino-2-[(2S)-6-amino-2-[(2S)-2-[(2R)-3-{[2,3-bis(hexadecanoyloxy)propyl]sulfanyl}-2-hexadecanamidopropanamido]-3-hydroxypropanamido]hexanamido]hexanamido]hexanamido]hexanoic acid  112208-00-1 Pam3CSK4 is a toll-like receptor 1/2 (TLR1/2) agonist with an EC50 of 0.47 ng/mL for human TLR1/2 .
CSN27303 1-(6-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine  132834-56-1 Org-12962 is a potent, selective and orally active 5-HT2C receptor agonist with a pEC50 value of 7.01. Org-12962 also exhibits high effacy for the 5-H
CSN27306 1-(9H-Fluoren-9-yl)-3-oxo-2,7,10-trioxa-4-azadodecan-12-oic acid  166108-71-0 Fmoc-8-amino-3,6-dioxaoctanoic acid (Fmoc-NH-PEG2-CH2COOH) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
CSN27302 7-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butoxy)quinolin-2(1H)-one  129722-25-4 Dehydroaripiprazole (OPC-14857) is an active metabolite of Aripiprazole. Aripiprazole is an antipsychotic agent and is metabolized by CYP3A4 and CYP2D
CSN27575 (2R,3R)-2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)chroman-4-one  54081-48-0 Isoastilbin is a dihydroflavonol glycoside compound in Rhizoma Smilacis glabrae and Astragalus membranaceus. Isoastilbin inhibits glucosyltransferase
CSN27383 3-Ethyl 5-methyl (S)-2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate  103129-82-4 Levamlodipine ((S)-Amlodipine) is a powerful dihydropyridine calcium channel blocker, possessing vasodilation properties and used in the treatment of
CSN27585 N-Methyl-9H-pyrido[3,4-b]indole-3-carboxamide  78538-74-6 FG 7142 (ZK 39106; LSU-65), a non-selectively benzodiazepine inverse agonist, has high affinity for the α1 subunit-containing GABAA receptor (Ki=91 nM
CSN27586 1-(4-Bromobenzyl)indole-2,3-dione  79183-37-2 VU0119498 is a M1 muscarinic receptor agonist with EC50 of 3.1 μM, and pan mAChR M3, M5 positive allosteric modulator (PAM),and is a neuroprotective a
CSN27595 7-Chloro-1-(4-(trifluoromethyl)benzyl)indoline-2,3-dione  85511-68-8 VU0238441 is a potent agonist of muscarinic acetylcholine receptor M5 with EC50 of 2.1 μM.
CSN27598 N-(4-Chlorophenyl)-4-(1H-indol-4-yl)piperazine-1-carboxamide  732973-87-4 GOT1 inhibitor 2c is a GOT1 inhibitor with IC50 value of 8.2μM.
CSN27656 2-(4-Chlorophenyl)-6-nitro-1H-1,3-benzodiazole  1571-87-5 GABAA receptor agent 1 is a high affinity ligand for GABAA receptor, with potent anticonvulsant activity.
CSN27669 (4-((2-(2,5-Dimethylphenoxy)ethyl)amino)piperidin-1-yl)(pyridin-4-yl)methanone  1309241-34-6 GRP-60367 is a potent and selective rabies virus (RABV) entry inhibitor with nanomolar potency against some RABV strains.
CSN27673 N-(1-(2,4-Bis(trifluoromethyl)benzyl)-1H-pyrazol-4-yl)-5-(furan-2-yl)isoxazole-3-carboxamide  2323027-38-7 Ceapin-A7 is a selective blocker of ATF6α signaling in response to ER stress with IC50 of 0.59 μM.
CSN27658 (E)-2-([1,1'-Biphenyl]-4-ylamino)-N-hydroxy-2-oxoacetimidoyl cyanide  1263303-95-2 DHODH-IN-11, a leflunomide derivative, is a weak inhibitor of dihydroorotate dehydrogenase (DHODH) with pKa of 5.03.
CSN27661 9-Isopropyl-N2,N6-bis(4-methoxybenzyl)-9H-purine-2,6-diamine  267402-71-1 Myoseverin is a microtuble-binding molecule and reversible inhibitor of tubulin polymerization. It binds to tublin leading to multinucleated myotubes
CSN27671 (R)-2-(6-(5-Chloro-2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)-1-oxoisoindolin-2-yl)-N-((S)-1-(3-fluoro-5-methoxyphenyl)-2-hydroxyethyl)propanamide  2095719-92-7 ASTX-029 is selective inhibitor of the extracellular signal-regulated kinases 1 and 2 (ERK 1/2) with potential antineoplastic activity.
CSN27659 Methyl 3-(4-methylbenzenesulfonamido)benzoate  173436-66-3 MSAB is a selective inhibitor of Wnt/β-catenin signaling. It binds to β-catenin promoting its degradation, and specifically downregulates Wnt/β-cateni
CSN52420 N-(3-Bromo-4-methylphenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine  300842-64-2
CSN27710 3-Mercaptopicolinic acid hydrochloride  320386-54-7 SKF-34288 HCl is a PEPCK inhibitor which could inhibit glucose synthesis through inhibition of PEPCK in the gluconeogenesis pathway.
CSN27724 3-Fluoro-N'-((5-nitrothiophen-2-yl)methylene)benzohydrazide  394694-98-5 MitoBloCK-10 is the first small molecule modulator to attenuate PAM (protein-associated motor) complex activity. It binds to a specific pocket in the
CSN27725 1,3-Bis(3,5-dichlorophenyl)urea  73439-19-7 COH-SR4 is an AMPK activator with anticancer properties. It significantly inhibited adipocyte differentiation in a dose-dependent manner in 3T3-L1 cel
CSN27766 5-(Bis(2-hydroxybenzyl)amino)-2-hydroxybenzoic acid  125697-91-8 Lavendustin B is a competitive Glut1 inhibitor with Ki value of 15µM.
CSN27767 (E)-2-(3,4-Dihydroxystyryl)-3-(2-methoxyphenyl)quinazolin-4(3H)-one  2041072-41-5 ICCB280 is a potent inducer of C/EBPα and myeloid differentiation.
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