||Cladribine is an adenosine deaminase inhibitor used to treat hairy cell leukemia and multiple sclerosis. For U266, RPMI8226, and MM1.S cells, its IC50
||Aliskiren is a renin inhibitor with IC50 of 1.5 nM.
||Atazanavir is a protease inhibitor used as an antiretroviral medication to treat and prevent HIV/AIDS.
||Azilsartan is an orally available angiotensin II type 1 (AT1) receptor antagonist with IC50 value of 2.6 nM.
||Ambrisentan is an oral, once-daily endothelin receptor antagonist that is selective for the endothelin type A receptor (IC50s = 0.251, 0.316, 0.398, 2
||Caffeic Acid Phenethyl Ester
||Caffeic acid phenethyl ester, a natural product isolated and purified from the barks of Cinnamomum cassia Presl, is a potent and specific inhibitor of
||DMXAA is an apoptosis inducer with anti-vascular activity. It can inhibit STING and enzyme DT-diaphorase (Ki = 20 μM).
||Erlotinib is an EGFR inhibitor with IC50 of 2 nM, > 1000-fold more sensitive for EGFR than human c-Src or v-Abl.
||Gefitinibis an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respe
||GW9662 selectively antagonizes PPARγ with IC50 of 3.3 nM. It can inhibit the growth of mammary cancer cells.
||GM6001 is a broad spectrum MMPs inhibitor for MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-12, MMP-14, and MMP-26 with Ki of 0.4 nM, 0.5 nM, 27 nM, 3
||Imatinib is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM in cell-free or cell-based assays, respectively.
||Lenalidomide, a analog of thalidomide, is TNF-α secretion inhibitor with IC50 of 13 nM.
||Lubiprostone is an ClC-2 chloride channel activator used in the treatment of idiopathic chronic constipation.
||Montelukast Sodium is a potent, selective and competitive LTR1 antagonist with IC50 value < 5 nM, possesssing anti-inflammatory and bronchodilating ac
||Pemetrexed is an antifolate and antimetabolite for TS(thymidylate synthase), DHFR(dihydrofolate reductase) and GARFT(glycinamide ribonucleotide formyl
||Roflumilast is a selective and long-acting inhibitor of PDE-4 with IC50 of 0.8 nM.
||Roscovitine is a potent and selective CDK inhibitor for Cdc2, CDK2 and CDK5 with IC50 of 0.65 μM, 0.7 μM and 0.16 μM and shows little effect on CDK4/6
||SB-203580 is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM.
||Tyrphostin AG 879
||Tyrphostin AG 879 potently inhibits HER2/ErbB2 with IC50 of 1 μM, 100- and 500-fold higher selective to ErbB2 than PDGFR and EGFR.
||BSI-201 is a PARP1 inhibitor with demonstrated effectiveness in triple-negative breast cancer (TNBC).
||Pixantrone dimaleate is a topoisomerase II inhibitor and DNA intercalator, with anti-tumor activity. Pixantrone dimaleate is an experimental antineopl
||Piceatannol, a natural stilbene, is selective Syk inhibitor extracted from the rhizomes of Polygonum cuspidatum Sieb. et Zucc..
||PD153035 is EGFR inhibitor with Ki and IC50 of 5.2 pM and 29 pM and could rapidly suppress autophosphorylation of EGFR.
||AG-1478 selectively inhibits EGFR with IC50 of 3 nM in cell-free assay.
||Fondaparinux sodium is a pentasaccharide inhibitor of antithrombin-dependent factor Xa (IC50 = 40 nM). It can bind to antithrombin III.
||Pioglitazone HCl is a selective agonist of PPARγ with EC50 of 0.93 μM which is used to treat diabetes.
||Combretastatin A4 is a tubulin polymerization inhibitor with Kd value of 0.4 μM for binding to β-tubulin.
||Tenofovir is an antiretroviral drug known as nucleotide analogue reverse transcriptase inhibitors (NRTIs), which block reverse transcriptase, a crucia
||Rosiglitazone maleate is the maleate form of rosiglitazone which is a high-affinity selective agonist of the peroxisome proliferator-activated recepto
||PD153035 HCl is an reversible inhibitor of EGFR with Ki and IC50 of 5.2 pM and 29 pM.
||Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Cabazitaxel exerts it
||Pomalidomide can inhibit LPS-induced TNF-α release with IC50 of 13 nM in PBMCs.
||Triapine is a ribonucleotide reductase inhibitor and a CDK inhibtor.
||PF-06840003 is a highly selective orally bioavailable IDO-1 inhibitor with IC50 of 0.41 μM.
||Licochalcone A, an estrogenic flavanoid, can be an inhibitor of p-glycoprotein and has anti-inflammatory actions.
||Metformin HCl, a widely used anti-diabetic drug has potential efficacy as an anti-cancer drug, decreasing hyperglycemia in hepatocytes primarily by su
||Alendronate Sodium Trihydrate
||Alendronate Sodium Trihydrate is an inhibitor of farnesyl diphosphate synthase with IC50 of 460 nM. It is used to treat osteoporosis.
||Calcifediol is an active metabolite of vitamin D. It can inhibit the secretion of parathyroid hormone with 2 nM and commonly used as an indicator of b
||Everolimus is a mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM.
||Fingolimod HCl is a S1P antagonist with IC50 of 0.033 nM.
||Erlotinib HCl is a directly acting inhibitor of human EGFR tyrosine kinase with an IC50 of 2 nM.
||Polydatin, extracted from the roots ofPolygonum cuspidatumSieb, a widely used traditional Chinese remedies, possesses anti-inflammatory activity in se
||Bexarotene is a selective agonist of RXRβ (IC50 = 24 nM), RXRγ (IC50 = 25 nM) and RXRα (IC50 = 33 nM) with antineoplastic activity.
||H 89 2HCl
||H 89 2HCl is a potent and selective inhibitor of cyclic AMP-dependent protein kinase (protein kinase A) with IC50 of 48 nM. It also shows weak inhibit
||ABT-751 can inhibit microtubule polymerization through binding to β-tubulin on the colchine site.
||Marimastat is a competitive and broad-spectrum MMP inhibitor with IC50 values of 3, 5, 6, 9 and 13 nM for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7, respe
||Elacridar is a P-glycoprotein inhibitor, and has been used both in vitro and in vivo as a tool inhibitor of P-glycoprotein (Pgp) to investigate the ro
||Lopinavir is an antiretroviral of the protease inhibitor class, as well as an inhibitor of P-Glycoprotein, Cytochrome P450 3A and Organic Anion Transp
||Ritonavir is both an HIV protease inhibitor and a Cytochrome P450 3A inhibitor.