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5-HT Receptor
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| CSN18369 | N-(2-(4-(2-Methoxyphenyl)piperazin-1-yl)ethyl)-N-(pyridin-2-yl)cyclohexanecarboxamide xmaleate | 634908-75-1 | WAY-100635 Maleate is both a potent and silent antagonist of 5-HT1A receptors with IC50 value of 2.2 nM and an agonist of dopamine D4 receptors. |
| CSN16799 | WAY-100635 | 162760-96-5 | WAY-100635 is a potent and selective 5-hydroxytryptamine1A antagonist with an IC50 of 0.95 ± 0.12 nM for 5-HT. |
| CSN13510 | VUF10166 | 155584-74-0 | VUF10166 is a potent and competitive antagonist for 5-HT3A receptor with Ki of 0.04 nM, its affinity at 5-HT3AB receptor is significantly lower. |
| CSN18372 | Urapidil HCl | 64887-14-5 | Urapidil HCl is a multiple-target antihypertensive drug as an α1-adrenoceptor antagonist, an α2-adrenoceptor agonist and an 5-HT1A receptor agonist. |
| CSN16285 | Tianeptine Sodium | 30123-17-2 | Tianeptine sodium salt is a selective facilitator of 5-HT uptake in vitro and in vivo. |
| CSN16779 | 7-((3-Chloro-6-methyl-5,5-dioxido-6,11-dihydrodibenzo[c,f][1,2]thiazepin-11-yl)amino)heptanoic acid | 72797-41-2 | Tianeptine is a unique tricyclic antidepressant, in contrast to SSRIs, which can increase serotonin uptake in the brain and reduce stress-induced atrophy of neuronal dendrites. |
| CSN16726 | Tegaserod maleate | 189188-57-6 | Tegaserod Maleate is a potent full agonist at 5-HT4 receptors with an EC50 value of 7 nM, used to treat irritable bowel syndrome associated with constipation and chronic constipation. |
| CSN17480 | Tandospirone citrate | 112457-95-1 | Tandospirone citrate is a potent and selective 5-HT1A receptor partial agonist (Ki = 27 nM) that displays selectivity over SR-2, SR-1C, α1, α2, D1 and D2 receptors (Ki values ranging from 1300-41000 nM). |
| CSN18478 | Setiptiline maleate | 85650-57-3 | Setiptiline is a serotonin receptor antagonist. |
| CSN16751 | Intepirdine | 607742-69-8 | SB-742457 is a selective 5-HT6 receptor antagonist with Ki value of 1.4 nM, showing potential cognition, memory, and learning-enhancing effects. |
| CSN18100 | SB 271046 HCl | 209481-24-3 | SB-271046 HCl is a potent, selective and orally active 5-HT6 receptor antagonist with pKi of 8.9. |
| CSN13858 | SB-269970 | 201038-74-6 | SB-269970 is a 5-HT7 receptor antagonist with pKi of 8.3, and exhibits > 50-fold selectivity against other receptors. |
| CSN17060 | RU 24969 | 66611-26-5 | RU 24969 is a selective agonist of the 5-HT1A and 5-HT1B receptors. |
| CSN18707 | Rizatriptan benzoate | 145202-66-0 | Rizatriptan Benzoate is a triptan-class 5-HT1 receptor agonist, used to treat migraine headaches. |
| CSN18379 | Risperidone mesylate | 666179-96-0 | Risperidone mesylate is a serotonin 5-HT2 receptor blocker (Ki= 0.16 nM) and a potent dopamine D2 receptor antagonist (Ki= 1.4 nM). |
| CSN18378 | 3-(2-(4-(6-Fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)ethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one hydrochloride | 666179-74-4 | Risperidone HCl is a serotonin 5-HT2 receptor blocker (Ki= 0.16 nM) and a potent dopamine D2 receptor antagonist (Ki= 1.4 nM). |
| CSN16886 | Ramosetron HCl | 132907-72-3 | Ramosetron HCl is a potent and selective 5-HT3 receptor antagonist for the treatment of nausea and vomiting. |
| CSN18500 | PRX-08066 | 866206-54-4 | PRX-08066 is a novel 5-HT2B receptor antagonist with IC50 of 3.4 nM. |
| CSN15934 | Prucalopride succinate | 179474-85-2 | Prucalopride Succinate is a selective and high-affinity 5-HT4 receptor agonist with enterokinetic activities. |
| CSN18174 | Pardoprunox | 269718-84-5 | Pardoprunox is a partial dopamine D2 (pKi = 8.1) and D3 (pKi = 8.6) receptor agonist (IA = 50% and 67%, respectively) and full serotonin 5-HT1A (pKi = 8.5) receptor agonist (IA = 100%), and also binds to D4 (pKi = 7.8), α1-adrenergic (pKi = 7.8), α2-adrenergic (pKi = 7.4), and 5-HT7 receptors (pKi = 7.2) with lower affinity. |
| CSN13827 | (S)-2-((S)-Quinuclidin-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-one hydrochloride | 135729-62-3 | Palonosetron HCl is a carbazole-derived and selective 5-HT3 receptor antagonist. |
| CSN14442 | p-Hydroxyphenethyl trans-ferulate | 84873-15-4 | p-Hydroxyphenethyl trans-ferulate, a natural product isolated and purified from the roots of Angelica sinensis, exhibits affinity toward 5-HT(7) receptors in a competitive binding assay. |
| CSN16686 | Ondansetron HCl | 99614-01-4 | Ondansetron is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy. |
| CSN15871 | 9-Methyl-3-((2-methyl-1H-imidazol-1-yl)methyl)-1,2,3,9-tetrahydro-4H-carbazol-4-one hydrochloride dihydrate | 103639-04-9 | Ondansetron HCl 2H2O is a competitive 5-HT3 receptor antagonist. |
| CSN16653 | Olanzapine | 132539-06-1 | Olanzapine is a multiple-target antagonist for 5-HT2A receptors and D2 dopamine receptors, as well as muscarinic M3 receptor. |
| CSN16338 | Nelotanserin | 839713-36-9 | Nelotanserin is a potent selective 5-HT2A inverse agonist, showing low nanomolar potency on the 5-HT2A receptor with at least 30- and 5000-fold selectivity compared with 5-HT2C and 5-HT2B receptors. |
| CSN17108 | 2-(4-(4-(2-Methoxyphenyl)piperazin-1-yl)butyl)isoindoline-1,3-dione hydrobromide | 115338-32-4 | NAN-190 hydrobromide is a serotonin receptor 5-HT antagonist. |
| CSN17035 | Lumateperone tosylate | 1187020-80-9 | Lumateperone tosylate is a 5-HT2A receptor antagonist (Ki = 0.54 nM), a partial agonist of presynaptic D2 receptors and an antagonist of postsynaptic D2 receptors (Ki = 32 nM), and a SERT blocker (Ki = 61 nM). |
| CSN18286 | Idalopirdine | 467459-31-0 | Lu AE58054 is an in-vitro potency and selectivity, in-vivo binding affinity and effect of the 5-HT(6)R antagonist with a Ki value of 0.83 nM. |
| CSN18285 | Idalopirdine HCl | 467458-02-2 | Lu AE58054 HCl is an anti-Alzheimer's agent with serotonin 5-HT6 receptor antagonist effect Ki value of 0.83 nM. |
| CSN13508 | 2,4,6-Trifluoro-N-(6-(1-methylpiperidine-4-carbonyl)pyridin-2-yl)benzamide | 439239-90-4 | Lasmiditan is a high-affinity, highly selective 5-HT1F receptor agonist (Ki=2.1 nM), compared with Ki of 1043 nM and 1357 nM at the 5-HT(1B) and 5-HT(1D) receptors, respectively. |
| CSN16459 | Ketanserin | 74050-98-9 | Ketanserin is a specific 5-HT2A serotonin receptor antagonist with Ki of 2.5 nM for rat and human 5-HT2A, used as an antihypertensive drug. |
| CSN16693 | Granisetron | 109889-09-0 | Granisetron is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy. |
| CSN13859 | GR 55562 hydrochloride | 172854-55-6 | GR55562 is a selective competitive 5-HT1B(5-HT1Dβ) silent antagonist with pKB values of 7.3 and 6.3 for human cloned 5-HT1B and 5-HT1D receptors respectively and only weak binding at a number of other 5-HT subtypes. |
| CSN17354 | Eptapirone | 179756-58-2 | F 11440 is a potent, selective and high efficacy 5-HT1A receptor agonist with pKi value of 8.33. |
| CSN15745 | Dolasetron Mesylate | 115956-13-3 | Dolasetron Mesylate is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy. |
| CSN13186 | Dolasetron | 115956-12-2 | Dolasetron is an indole-derived and potent 5-HT3 receptor antagonist with anti-emetic property. |
| CSN18519 | Dolasetron Mesylate hydrate | 878143-33-0 | Dolasetron is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy. |
| CSN17333 | 4-(5H-Dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine hydrochloride | 969-33-5 | Cycloheptadine HCl is a 5-HT2A receptor antagonist which can inhibit serotonin-enhanced platelet function. |
| CSN16591 | CP-809101 HCl | 1215721-40-6 | CP-809101 HCl is a potent and selective 5-HT2C receptor agonist with pEC50 of 9.96/7.19/6.81 for human 5-HT2C/5-HT2B/5-HT2A receptors respectively. |
| CSN13853 | BRL 54443 | 57477-39-1 | BRL 54443 is a selective agonist for 5-HT1E and 5-HT1F receptor with pEC50 values of 8.5 and 8.6. |
| CSN15692 | Brexpiprazole | 913611-97-9 | Brexpiprazole is a partial agonist of the serotonin 5-HT1A receptor and the dopamine D2 and D3 receptors, used as an atypical antipsychotic for the treatment of schizophrenia and major depressive disorders. |
| CSN17812 | Asenapine HCl | 1412458-61-7 | Asenapine HCl inhibits adrenergic receptor (α1, α2A, α2B, α2C) with Ki of 0.25-1.2 nM and also inhibits 5-HT receptor(1A, 1B, 2A, 2B, 2C, 5A, 6, 7) with Ki of 0.03-4.0 nM. |
| CSN18262 | Amitifadine hydrochloride | 410074-74-7 | Amitifadine HCl is a triple reuptake inhibitor (TRI) or serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI). |
| CSN18450 | Agomelatine (L(+)-Tartaric acid) | 824393-18-2 | Agomelatine L(+)-tartaric acid is an antidepressant, which is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor. |
| CSN16711 | Agomelatine | 138112-76-2 | Agomelatine is a melatonin structurely similar 5-HT2C receptor antagonist as well as a potent melatonin receptor agonist, used to treat major depressive disorder. |
| CSN17518 | Agomelatine HCl | 1176316-99-6 | Agomelatine HCl is an antidepressant, which is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor. |
| CSN103350 | 2-(4-(4-(2-Methoxyphenyl)piperazin-1-yl)butyl)isoindoline-1,3-dione hydrobromide | 115338-32-4 |
