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5-HT Receptor
货号 | 产品名 | CAS号 | 信息 |
---|---|---|---|
CSN21267 | YM348 | 372163-84-3 | YM348 is a potent and orally active 5-HT2C receptor agonist, which shows a high affinity for cloned human 5-HT2C receptor (Ki: 0.89 nM). |
CSN18999 | Hypidone HCl | 1339058-04-6 | YL0919 is a dual 5-HT1A partial agonist and SSRI, producing antidepressant- and anxiolytic-like effects. |
CSN18831 | N-(2-(4-(2-Methoxyphenyl)piperazin-1-yl)ethyl)-N-(pyridin-2-yl)cyclohexanecarboxamide Maleate | 1092679-51-0 | WAY-100635 fumarate is a potent and selective 5-HT receptor antagonist with IC50 of 0.95 nM. |
CSN22124 | WAY 163909 | 428868-32-0 | WAY 163909 is a potent and selective 5-HT(2C) receptor agonist with Ki of 10.5±1.1 nM, respectively. |
CSN19265 | SB 242084 | 181632-25-7 | SB-242084 is a 5-HT2C receptor antagonist (pKi=9.0) that displays 158- and 100-fold selectivity over 5-HT2A and 5-HT2B receptors respectively. |
CSN19474 | Sarpogrelate HCl | 135159-51-2 | Sarpogrelate HCl is an antagonist of both 5HT2A and 5-HT2B receptors, which can block serotonin-induced platelet aggregation and treat diabetes mellitus, Buerger's disease, Raynaud's disease, coronary artery disease, angina pectoris and atherosclerosis. |
CSN20353 | RS 67333 HCl | 168986-60-5 | RS-67333 HCl is a potent and highly selective 5-HT4 partial agonist, with pKi values of 8.7 at 5-HT4 sites in guinea pig striatum and > 6 at various other receptors, including 5-HT1A, 1D, 2A, 2C, D1, D2 and M1-3. It is also active in vivo, with an intrinsic activity relative to 5-HT of 0.5. |
CSN20273 | Ro60-0175 fumarate | 169675-09-6 | Ro 60-0175 is a 5HT2C receptor agonist. |
CSN22178 | PRX933 HCl | 639029-42-8 | PRX933 HCl is a 5-HT2c receptor agonist. |
CSN19227 | PRX-08066 maleate | 866206-55-5 | PRX-08066 maleic acid is a selective 5-HT2B receptor antagonist with IC50 of 3.4 nM, prevents the severity of pulmonary arterial hypertension in the MCT rat model. |
CSN20437 | LP-211 | 1052147-86-0 | P-211 is an a selective agonist of the serotonin 5-HT7 receptor with a Ki value of 0.58 nM at rat cloned 5-HT7 receptors, and > 300-fold selectivity over the 5-HT1A receptor. |
CSN20577 | Ocaperidone | 129029-23-8 | Ocaperidone is a benzisoxazole is an antagonist of both 5HT and D2 receptors. |
CSN20313 | Befiradol | 208110-64-9 | NLX-112 is a potent and efficacious serotonin 5-HT1A receptor agonist potentially for the treatment of drug-induced dyskinesia in patients. |
CSN21278 | Methiothepin mesylate | 74611-28-2 | Methiothepin mesylate is a potent and non-selective 5-HT2 receptor antagonist, with pKds of 7.10 (5-HT1A), 7.28 (5HT1B), 7.56 (5HT1C), 6.99 (5HT1D), 7.0 (5-HT5A), 7.8 (5-HT5B), 8.74 (5-HT6), and 8.99 (5-HT7), and pKis of 8.50 (5HT2A), 8.68 (5HT2B), and 8.35 (5HT2C). |
CSN19837 | (2,3-Dimethoxyphenyl)(1-(4-fluorophenethyl)piperidin-4-yl)methanol | 139290-69-0 | MDL 100151 is a selective 5-HT2A antagonist. |
CSN19000 | LY 344864 S-enantiomer | 186544-27-4 | LY 344864 S-enantiomer is the S-enantiomer of LY344864. |
CSN22452 | LY 344864 HCl | 1217756-94-9 | LY 344864 HCl is a selective 5-HT1F agonist with a Ki of 6 nM. |
CSN21141 | LY334370 | 182563-08-2 | LY 334370 is a selective 5-HT1F receptor agonist (Ki=1.6nM). LY 334370 HCl displays antimigraine effects. |
CSN21902 | Lurasidone | 367514-87-2 | Lurasidone functions as an antagonist of the dopamine D2 and D3 receptors, the serotonin 5-HT2A and 5-HT7 receptors, the α2C-adrenergic receptor, and as a partial agonist of the serotonin 5-HT1A receptor. |
CSN18968 | Latrepirdine 2HCl | 97657-92-6 | Latrepirdine is an orally active,and neuroactive antagonist of multiple drug targets, including histamine receptors, GluR, and 5-HT receptors, used as an antihistamine drug. |
CSN18709 | Flopropione | 2295-58-1 | Flopropione is both a 5-HT1A receptor antagonist and a COMT inhibitor as a spasmolytic or antispasmodic agent. |
CSN20462 | E-6837 | 528859-61-2 | E-6837 is an orally active, 5-HT6 agonist developed in an attempt to create an anti-obesity medication. |
CSN21976 | Deschloroclozapine | 1977-07-7 | Dopamine serotonin antagonist-1 is antagonist of dopamine and serotonin receptor, the Kis for dopamine D1/D2/D4, and serotonin S2A/S2C/S3 are 200/2500/420 nM and 39/84/40 nM, respectively. |
CSN21602 | Desipramine HCl | 58-28-6 | Desipramine HCl is a dibenzazepine-derived tricyclic antidepressant which can selectively block reuptake of norepinephrine from the neural synapse, and also appear to impair serotonin transport. |
CSN19266 | CP-809101 | 479683-64-2 | CP-809101 is a potent and selective 5-HT2C receptor agonist with pEC50 of 9.96/7.19/6.81 for human 5-HT2C/5-HT2B/5-HT2A receptors respectively. |
CSN22722 | BP 554 maleate | 1221401-95-1 | BP 554 Maleate is a selective 5-HT1A agonist. |
CSN22714 | BIMU 8 | 134296-40-5 | BIMU 8 is a potent 5-HT4 receptor full agonist with KD of 77 nM and EC50 of 18 nM for wild type 5-HT4 receptors. |
CSN19406 | Azacyclonol | 115-46-8 | Azacyclonol is an ataractive agent, inhibiting shock-induced elevation of catecholamine levels in the brain and showing central depressant effects. |
CSN20672 | Aripiprazole Lauroxil | 1259305-29-7 | Aripiprazole lauroxil is a long-acting injectable atypical antipsychotic. It is an N-acyloxymethyl prodrug of aripiprazole that is administered via intramuscular injection once every four to six weeks for the treatment of schizophrenia. |
CSN22192 | AR-A 2 | 220051-79-6 | AR-A 2 is a selective 5-HT1B receptor antagonist, with high affinity to guinea pig cortex 5HT1B/1D and recombinant guinea pig 5-HT1B receptors (Ki=0.24 and 0.47 nM) and with 10-fold lower affinity to guinea pig 5-HT1D receptor (Ki=5 nM), and shows an EC50 of 4.5 nM for the guinea pig 5-HT1B receptor; AR-A 2 can be used in the research of depression and anxiety. |
CSN22348 | AP521 | 151227-08-6 | AP521 is an agonist of human 5-HT1A receptor with an IC50 of 94 nM. |
CSN19442 | Alverine citrate | 5560-59-8 | Alverine Citrate is a 5-HT1A receptor antagonist with IC50 value of 101 nM. |
CSN22674 | Altanserin hydrochloride | 1135280-78-2 | Altanserin HCl is a potent and selective 5-HT2A receptor antagonist with Ki of 0.13 nM. |
CSN22331 | 5-HT7 agonist 1 | 334974-31-1 | 5-HT7 agonist 1 is a selective 5-HT7 receptor agonist, with an IC50 of 222.93 nM, can be used for the 5-HT7 receptor related disease, such as CNS disorders. |
CSN22190 | 5-HT4 antagonist 1 | 261766-73-8 | 5-HT4 antagonist 1 is a 5-HT4 receptor antagonist with a pKi of 9.6. |
CSN21310 | 5-HT1A modulator 1 | 142477-34-7 | 5-HT1A modulator 1 displays very high affinities for the 5HT1A, adrenergic α1 and dopamine D2 receptor with IC50s of 2 ±0.3 nM, 10 ± 3 nM and 40 ±9 nM, respectively. |
CSN22651 | 4F 4PP oxalate | 144734-36-1 | 4F 4PP Oxalate is a selective 5-HT2A antagonist with Ki of 5.3 nM. |
CSN22649 | 3-AQC | 201216-42-4 | 3-AQC is a competitive 5-HT3 antagonist. |
CSN22642 | N-Phenylimidodicarbonimidic diamide hydrochloride | 55-57-2 | 1-Phenylbiguanide HCl is a biguanide-class 5-HT3 agonist. |
CSN22619 | MCN-5652 | 96795-89-0 | (±)-McN 5652 is a potent, orally active 5-HT uptake inhibitor and also inhibits noradrenalin and dopamine uptake in vitro. |
CSN22639 | (S)-WAY 100135 dihydrochloride | 149007-54-5 | (S)-WAY 100135 2HCl is a potent, selective 5-HT1A receptor antagonist with IC50 of 15 nM. |
CSN50166 | 2-Benzyl-1-methyl-5-nonylpyrrolidin-3-ol | 119463-16-0 |