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5-HT Receptor

5-HT Receptor

货号 产品名 CAS号 信息
CSN26541 ZK756326 2HCl 1780259-94-0 ZK-756326 is a potent, selective and non-peptide CCR8 chemokine receptor agonist. ZK 756326 inhibited the binding of the CCR8 ligand I-309 (CCL1), with an IC(50) value of 1.8 muM. ZK 756326 was a full agonist of CCR8, dose-responsively eliciting an increase in intracellular calcium and cross-desensitizing the response of the receptor to CCL1.
CSN21856 Tertatolol 83688-84-0 Tertatolol is a potent antagonist of beta-adrenoceptor and 5-HT receptor, with unique renal vasodilatatory effects.
CSN22076 Temanogrel 887936-68-7 Temanogrel is a highly selective 5-HT2A receptor antagonist with Ki of 4.9 nM.
CSN11918 Sertindole 106516-24-9 Sertindole, a neuroleptic, is one of the antipsychotic medications available, with a high affinity for dopamine D2, serotonin 5-HT2A, 5-HT2C, and α1-adrenergic receptors.
CSN26560 SEP-363856 1310426-33-5 SEP-363856 (SEP-856), an orally active and CNS active psychotropic agent with a unique, non-D2/5-HT2A mechanism of action, exerts its antipsychotic-like effects. SEP-363856 (SEP-856) has the potential for the treatment of schizophrenia[1].
CSN21989 SB-224289 HCl 180084-26-8 SB-224289 hydrochloride is a selective 5-HT1B receptor antagonist, with anxiolytic effect.
CSN26568 SB-200646 143797-63-1 SB-200646 is the first selective 5-HT2B/2C over 5-HT2A receptor antagonist with pKi values of 7.5, 6.9 and 5.2 for 5-HT2B, 5-HT2C and 5-HT2A, respectively. SB-200646 is orally active and has electrophysiological and anxiolytic properties in vivo[1][2].
CSN26532 Sarizotan 351862-32-3 Sarizotan (EMD 128130) is an orally active serotonin 5-HT1A receptor and dopamine receptor agonist. Sarizotan (EMD 128130) exhibits IC50 values of 6.5 nM (rat 5-HT1A), 0.1 nM (human 5-HT1A), 15.1 nM (rat D2), 17 nM (human D2), 6.8 nM (human D3) and 2.4 nM (human D4.2), respectively[1].
CSN13491 RS-127445 199864-87-4 RS 127445 is a potent and selective antagonist at 5-HT2B receptor with pKi value of 9.5.
CSN33114 Roluperidone 359625-79-9 Roluperidone is a 5-HT2A and sigma 2 receptor antagonist.
CSN26383 R 59-022 93076-89-2 R 59-022 is a diacylglycerol kinase inhibitor with IC50 of 2.8 μM. R 59-022 is a 5-HTR antagonist, and activates protein kinase C (PKC). R 59-022 potentiates thrombin-induced diacylglycerol production in platelets and inhibits phosphatidic acid production in neutrophils[1][2][3][4].
CSN21782 Pancopride 121650-80-4 Pancopride is a selective antagonist of 5-HT3 receptor.
CSN11590 (R)-1,2-Dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline 475-83-2 Nuciferine is naturally occuring alkaloid found in the plants Nymphaea caerulea and Nelumbo nucifera as a potent inverse agonist at human 5-HT7 receptor.
CSN21712 Lintopride 107429-63-0 Lintopride is an antagonist of 5HT4 receptor and moderate antagonist of 5HT3.
CSN21711 Lidanserin 73725-85-6 Lidanserin is antagonist of 5-HT2A and α1-adrenergic receptor.
CSN26570 Lesopitron 2HCl 132449-89-9 Lesopitron dihydrochloride is a 5-HT1A receptor agonist potentially for the treatment of generalized anxiety disorder.
CSN12998 Lamotrigine 84057-84-1 Lamotrigine is a member of the sodium channel blocking class of antiepileptic drugs which can block L-, N-, and P-type calcium channels and has weak 5-HT3 receptor inhibition.
CSN18311 Isocorynoxeine 51014-29-0 Isocorynoxeine, a major alkaloid found in Uncaria rhynchophylla, exhibits wide beneficial effects on the cardiovascular and cardiocerebral vascular systems.
CSN21695 Irindalone 96478-43-2 Irindalone is an antagonist of serotonin 5-HT2 receptor.
CSN27680 GR 125743 148547-33-5 GR 125743 is a novel 5-HT1B/1D receptor antagonist.
CSN20976 Geissoschizine methyl ether 60314-89-8 Geissoschizine methyl ether is a potent serotonin A receptor agonist.
CSN26499 Fiduxosin 208993-54-8 Fiduxosin is an alpha(1)-adrenoceptor antagonist with higher affinity for alpha(1A)-adrenoceptors and for alpha(1D)-adrenoceptors than for alpha(1B)-adrenoceptors.
CSN21600 Deramciclane 120444-71-5 Deramciclane is an antagonist of 5-HT2A and inverse agonist of 5-HT2C receptor. It also functions as a GABA reuptake inhibitor.
CSN21594 Dazopride 70181-03-2 Dazopride is an antiemetic agent which acts as a 5-HT3 receptor antagonist and 5-HT4 receptor agonist.
CSN33115 CYR-101 HCl 2H2O 1937215-88-7 CYR-101 hydrochloride dihydrate is a 5-HT2A and sigma 2 receptor antagonist.
CSN32884 AVN-211 1173103-84-8 AVN-211 is a Novel and Highly Selective 5-HT6 Receptor Small Molecule Antagonist for the Treatment of Alzheimer's Disease.
CSN33129 (R)-6-Chloro-4-methyl-3-oxo-N-(quinuclidin-3-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-carboxamide 2025360-90-9 Arazasetron is an antiemetic which acts as a 5-HT3 receptor antagonist, pKi = 9.27.
CSN33130 (R)-Azasetron besylate 2025360-91-0 Arazasetron besylate is an antiemetic which acts as a 5-HT3 receptor antagonist, pKi = 9.27.
CSN21450 Abaperidone 183849-43-6 Abaperidone is an antagonist of 5-HT2A receptor and dopamine D2 receptor with IC50s of 6.2 and 17 nM respectively.
CSN24609 3-MPPI 133399-65-2 3-MPPI is a very potent ligand for α1 sites and regulates smooth muscle contraction. The pKi values for α1B, α1D, α1A adrenoceptors are 8.74, 9.44, 9.57 respectively. It also binds to 5-HT1A sites (Ki = 50 nM).
CSN21566 (Z)-Thiothixene 3313-26-6 (Z)-Thiothixene is serotonergic receptor antagonist.
CSN32430 Piromelatine 946846-83-9
CSN38722 Brilaroxazine 1239729-06-6
CSN42110 Spiperone HCl 2022-29-9
CSN40713 OPC-14523 145969-30-8
CSN34043 OPC-14523 HCl 145969-31-9
CSN36535 Pimethixene maleate 13187-06-9
CSN34474 QF0301B 149247-12-1
CSN34000 MHP 133 147340-43-0
CSN42968 Tedatioxetine HBr 960151-65-9
CSN63870 Paliperidone-d4 1020719-55-4
CSN62938 1-(3-(2-(Bis(methyl-d3)amino)ethyl)-1H-indol-5-yl)-N-methylmethanesulfonamide 1020764-38-8
CSN62856 Quetiapine-d8 fumarate 1185247-12-4
CSN62957 Sumatriptan-d6 Succinate 1215621-31-0
CSN83992 3-(10,10-Dimethylanthracen-9(10H)-ylidene)-N,N-dimethylpropan-1-amine 5118-29-6
CSN90871 Pipamperone dihydrochloride 2448-68-2
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