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5-HT Receptor
货号 | 产品名 | CAS号 | 信息 |
---|---|---|---|
CSN26541 | ZK756326 2HCl | 1780259-94-0 | ZK-756326 is a potent, selective and non-peptide CCR8 chemokine receptor agonist. ZK 756326 inhibited the binding of the CCR8 ligand I-309 (CCL1), with an IC(50) value of 1.8 muM. ZK 756326 was a full agonist of CCR8, dose-responsively eliciting an increase in intracellular calcium and cross-desensitizing the response of the receptor to CCL1. |
CSN21856 | Tertatolol | 83688-84-0 | Tertatolol is a potent antagonist of beta-adrenoceptor and 5-HT receptor, with unique renal vasodilatatory effects. |
CSN22076 | Temanogrel | 887936-68-7 | Temanogrel is a highly selective 5-HT2A receptor antagonist with Ki of 4.9 nM. |
CSN11918 | Sertindole | 106516-24-9 | Sertindole, a neuroleptic, is one of the antipsychotic medications available, with a high affinity for dopamine D2, serotonin 5-HT2A, 5-HT2C, and α1-adrenergic receptors. |
CSN26560 | SEP-363856 | 1310426-33-5 | SEP-363856 (SEP-856), an orally active and CNS active psychotropic agent with a unique, non-D2/5-HT2A mechanism of action, exerts its antipsychotic-like effects. SEP-363856 (SEP-856) has the potential for the treatment of schizophrenia[1]. |
CSN21989 | SB-224289 HCl | 180084-26-8 | SB-224289 hydrochloride is a selective 5-HT1B receptor antagonist, with anxiolytic effect. |
CSN26568 | SB-200646 | 143797-63-1 | SB-200646 is the first selective 5-HT2B/2C over 5-HT2A receptor antagonist with pKi values of 7.5, 6.9 and 5.2 for 5-HT2B, 5-HT2C and 5-HT2A, respectively. SB-200646 is orally active and has electrophysiological and anxiolytic properties in vivo[1][2]. |
CSN26532 | Sarizotan | 351862-32-3 | Sarizotan (EMD 128130) is an orally active serotonin 5-HT1A receptor and dopamine receptor agonist. Sarizotan (EMD 128130) exhibits IC50 values of 6.5 nM (rat 5-HT1A), 0.1 nM (human 5-HT1A), 15.1 nM (rat D2), 17 nM (human D2), 6.8 nM (human D3) and 2.4 nM (human D4.2), respectively[1]. |
CSN13491 | RS-127445 | 199864-87-4 | RS 127445 is a potent and selective antagonist at 5-HT2B receptor with pKi value of 9.5. |
CSN33114 | Roluperidone | 359625-79-9 | Roluperidone is a 5-HT2A and sigma 2 receptor antagonist. |
CSN26383 | R 59-022 | 93076-89-2 | R 59-022 is a diacylglycerol kinase inhibitor with IC50 of 2.8 μM. R 59-022 is a 5-HTR antagonist, and activates protein kinase C (PKC). R 59-022 potentiates thrombin-induced diacylglycerol production in platelets and inhibits phosphatidic acid production in neutrophils[1][2][3][4]. |
CSN21782 | Pancopride | 121650-80-4 | Pancopride is a selective antagonist of 5-HT3 receptor. |
CSN11590 | (R)-1,2-Dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline | 475-83-2 | Nuciferine is naturally occuring alkaloid found in the plants Nymphaea caerulea and Nelumbo nucifera as a potent inverse agonist at human 5-HT7 receptor. |
CSN21712 | Lintopride | 107429-63-0 | Lintopride is an antagonist of 5HT4 receptor and moderate antagonist of 5HT3. |
CSN21711 | Lidanserin | 73725-85-6 | Lidanserin is antagonist of 5-HT2A and α1-adrenergic receptor. |
CSN26570 | Lesopitron 2HCl | 132449-89-9 | Lesopitron dihydrochloride is a 5-HT1A receptor agonist potentially for the treatment of generalized anxiety disorder. |
CSN12998 | Lamotrigine | 84057-84-1 | Lamotrigine is a member of the sodium channel blocking class of antiepileptic drugs which can block L-, N-, and P-type calcium channels and has weak 5-HT3 receptor inhibition. |
CSN18311 | Isocorynoxeine | 51014-29-0 | Isocorynoxeine, a major alkaloid found in Uncaria rhynchophylla, exhibits wide beneficial effects on the cardiovascular and cardiocerebral vascular systems. |
CSN21695 | Irindalone | 96478-43-2 | Irindalone is an antagonist of serotonin 5-HT2 receptor. |
CSN27680 | GR 125743 | 148547-33-5 | GR 125743 is a novel 5-HT1B/1D receptor antagonist. |
CSN20976 | Geissoschizine methyl ether | 60314-89-8 | Geissoschizine methyl ether is a potent serotonin A receptor agonist. |
CSN26499 | Fiduxosin | 208993-54-8 | Fiduxosin is an alpha(1)-adrenoceptor antagonist with higher affinity for alpha(1A)-adrenoceptors and for alpha(1D)-adrenoceptors than for alpha(1B)-adrenoceptors. |
CSN21600 | Deramciclane | 120444-71-5 | Deramciclane is an antagonist of 5-HT2A and inverse agonist of 5-HT2C receptor. It also functions as a GABA reuptake inhibitor. |
CSN21594 | Dazopride | 70181-03-2 | Dazopride is an antiemetic agent which acts as a 5-HT3 receptor antagonist and 5-HT4 receptor agonist. |
CSN33115 | CYR-101 HCl 2H2O | 1937215-88-7 | CYR-101 hydrochloride dihydrate is a 5-HT2A and sigma 2 receptor antagonist. |
CSN32884 | AVN-211 | 1173103-84-8 | AVN-211 is a Novel and Highly Selective 5-HT6 Receptor Small Molecule Antagonist for the Treatment of Alzheimer's Disease. |
CSN33129 | (R)-6-Chloro-4-methyl-3-oxo-N-(quinuclidin-3-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-carboxamide | 2025360-90-9 | Arazasetron is an antiemetic which acts as a 5-HT3 receptor antagonist, pKi = 9.27. |
CSN33130 | (R)-Azasetron besylate | 2025360-91-0 | Arazasetron besylate is an antiemetic which acts as a 5-HT3 receptor antagonist, pKi = 9.27. |
CSN21450 | Abaperidone | 183849-43-6 | Abaperidone is an antagonist of 5-HT2A receptor and dopamine D2 receptor with IC50s of 6.2 and 17 nM respectively. |
CSN24609 | 3-MPPI | 133399-65-2 | 3-MPPI is a very potent ligand for α1 sites and regulates smooth muscle contraction. The pKi values for α1B, α1D, α1A adrenoceptors are 8.74, 9.44, 9.57 respectively. It also binds to 5-HT1A sites (Ki = 50 nM). |
CSN21566 | (Z)-Thiothixene | 3313-26-6 | (Z)-Thiothixene is serotonergic receptor antagonist. |
CSN32430 | Piromelatine | 946846-83-9 | |
CSN38722 | Brilaroxazine | 1239729-06-6 | |
CSN42110 | Spiperone HCl | 2022-29-9 | |
CSN40713 | OPC-14523 | 145969-30-8 | |
CSN34043 | OPC-14523 HCl | 145969-31-9 | |
CSN36535 | Pimethixene maleate | 13187-06-9 | |
CSN34474 | QF0301B | 149247-12-1 | |
CSN34000 | MHP 133 | 147340-43-0 | |
CSN42968 | Tedatioxetine HBr | 960151-65-9 | |
CSN63870 | Paliperidone-d4 | 1020719-55-4 | |
CSN62938 | 1-(3-(2-(Bis(methyl-d3)amino)ethyl)-1H-indol-5-yl)-N-methylmethanesulfonamide | 1020764-38-8 | |
CSN62856 | Quetiapine-d8 fumarate | 1185247-12-4 | |
CSN62957 | Sumatriptan-d6 Succinate | 1215621-31-0 | |
CSN83992 | 3-(10,10-Dimethylanthracen-9(10H)-ylidene)-N,N-dimethylpropan-1-amine | 5118-29-6 | |
CSN90871 | Pipamperone dihydrochloride | 2448-68-2 |